1.Chemical constituents from Centipeda minima.
Shoucheng PU ; Yuanqiang GUO ; Wenyuan GAO
China Journal of Chinese Materia Medica 2009;34(12):1520-1522
OBJECTIVETo study the chemical constituents from Centipeda minima.
METHODThe constituents were isolated by column chromatography on silica gel, Sephadex LH-20 and HPLC-ODS, and identified by spectroscopic methods.
RESULTTen compounds, (-)-cis-chrysanthenol-O-beta-D-glucopyranoside (1), methy 3,5-dicaffeoylquinate (2), 3,5-di-O-caffeoyl quinicacid (3), tricin (4), 2-amino-4-methyl-pentanoicacid (5), 2-amino-3-phenyl-propionic acid (6), 4-amino-4-carboxychroman-2-one (7), brevilin-A (8), arnicolide C (9), arnicolide D (10) were isolated and identified.
CONCLUSIONCompounds 1-7 were isolated from the plant for the first time.
Asteraceae ; chemistry ; Drugs, Chinese Herbal ; analysis ; isolation & purification
2.Recent advance in lymphatic drainage of central nervous system affecting clearance of β-amyloid
Junmei CHEN ; Yun LING ; Songxian SUN ; Wenyuan PU ; Chunxiang ZHOU
Chinese Journal of Neuromedicine 2019;18(3):302-305
Central nervous system lymphatic drainage system (CNSLDS) is composed of glymphatic system, perivascular lymphatic drainage pathways and meningeal lymphatic vessels. Based on new findings of structures and functions of CNSLDS, CNSLDS is one of the mechanisms for promoting the clearance of β-amyloid (Aβ). CNSLDS functions physiologically as a route of drainage for Aβ from glymphatic system or perivascular lymphatic drainage pathways to meningeal lymphatic vessels, and the meningeal lymphatic vessels helps Aβ drainage to the nearby lymph nodes. In this review, we summarize the key component elements (structure and function) in the clearance of Aβ during the CNS lymphatic drainage. Also, we highlight their potential roles in the pathogenesis of Alzheimer's disease and their clinical importance in diagnosis and treatment of neurologic diseases associated with Aβ, including Alzheimer's disease.
3.Internal fixation of lateral and medial borders for displaced scapular body fractures via minimally invasive approach:results of 23 cases
Mingxuan GAO ; Dejun NIE ; Yanfeng CHANG ; Weiqiang XIE ; Yue WANG ; Xingyu PU ; Wei ZHANG ; Wenyuan LUO
Journal of Zhejiang University. Medical sciences 2019;48(6):651-656
OBJECTIVE: To evaluate the efficacy of internal fixation of lateral and medial borders for displaced scapular body fractures via the minimally invasive approach. METHODS: The internal fixation of lateral and medial borders via minimally invasive approach was applied in surgical treatment of 23 patients with scapular body comminuted fractures from January 2014 to June 2018. The lateral approach was made straightly orienting over the lateral border of scapula. The dissection was taken down to the deltoid fascia. The deltoid was retracted cephalically, revealing the external rotators. Blunt dissection was used down to the lateral border between infraspinatus and teres minor, exposing the fracture site. The medial incision was done along the medial border of the scapula over site of the fracture. Dissections were taken down to the fascia and the periosteum. A subperiosteal dissection was then performed to elevate the infraspinatus to the degree necessary to visualize the fracture. The medial and lateral borders of scapula body were fixed with plates and screws in a frame-like way. RESULTS One patient developed the delayed healing of the incisions due to liquefactive fat necrosis. The other 22 patients showed no complications of the incisions. The glenopolar angle (GPA) of fractured scapula was increased from preoperative (25±12) degrees to postoperative (41±5) degrees (P<0.01). The healing time of fractures healed was 3-8 months, with an average time of (4.4±1.3) months. CONCLUSIONS The lateral-medial combined fixation through minimally invasive surgical approach for the scapula body fractures allows visualization of fracture reduction without extensive muscular or subcutaneous flaps, and is associated with successful fracture healing and high functional scores of the shoulder.