1.S100A7:Biological properties and implications in diseases
Ye LIU ; Wenyan SUN ; Jiangang LONG ; Jiankang LIU
Journal of Medical Postgraduates 2014;(7):767-771
S100 A7 is a small calcium-binding protein that has an important role to play in the differentiation of human kerati -nocytes.It also helps build the chemical defense system of the skin and responds to oxidative stress and inflammation .The expression of S100 A7 can be induced by physical , chemical and biological stimulations .S100 A7 has many ligands and is related to the reactive oxygen species (ROS) via specific signaling pathways.As an important antimicrobial peptide, S100A7 helps the skin fight against main pathogens .S100 A7 is also a key indicator for the state of inflammation and cell differentiation;and its up-regulation has been cor-roborated in various skin diseases .In the brain of patients with Alzheimer′s disease, the up-regulation of S100A7 in primary cortico-hippocampal neurons can inhibit the generation of β-amyloid peptides .Moreover , S100 A7 is also up-regulated in different types of cancer and closely related to tumor malignancy and progression .In this review, we introduce biological properties of S 100A7 and high-light its expression characteristic in related diseases .This should have implication for the discovery of potential biomarkers and targets for the treatment of S100A7-related diseases.
2.Research progress of vaccine hesitancy in China in recent years
Liqin LU ; Xiaohua WANG ; Wenyan LONG ; Zhengang WEI ; Qiuxiang LI
Shanghai Journal of Preventive Medicine 2023;35(9):928-934
The 2030 Immunization Agenda of the World Health Organization (WHO) states that everyone in the world should fully benefit from vaccines to achieve good health and well-being. With the ever-changing disease spectrum and the improvement of residents' health literacy, relying solely on vaccines included in the National Immunization Program (NIP) is insufficient to meet the current requirements for disease prevention and control. Non-NIP vaccines play an important role in meeting people's diverse needs. Vaccine hesitancy is a global issue and an important factor affecting vaccine uptake. By reviewing relevant studies on vaccine hesitancy in recent years, this paper summarized different vaccination situations, current situation of vaccine hesitancy, measuring tools of vaccine hesitancy, and major influencing factors. It aims to provide references for the development of scientific and effective vaccine education strategies, which can increase public knowledge and understanding of vaccines, enhance healthcare professional's willingness and behavior in recommending vaccines, improve public vaccine literacy, and reduce vaccine hesitancy. At the same time, the supervision and guidance of media discourse should be strengthened to enhance the protective role of non-NIP vaccines in immunization barriers.
3.Epidemiological characteristics of local outbreak of COVID-19 caused by SARS-CoV-2 Delta variant in Liwan district, Guangzhou.
WenYan LI ; ZhiCheng DU ; Ying WANG ; Xiao LIN ; Long LU ; Qiang FANG ; WanFang ZHANG ; MingWei CAI ; Lin XU ; YuanTao HAO
Chinese Journal of Epidemiology 2021;42(10):1763-1768