1.Comparative of paliperidone extended release tablets and risperidone tablets for women's glycolipid metabolism of episode schizophrenia
Drug Evaluation Research 2017;40(1):79-82
Objective To compare the sustained-release tablets paliperidone and risperidone tablets starting glycolipid metabolism in female patients with schizophrenia.Methods Eighty-five cases of women treated in our hospital episode schizophrenia patients were randomly divided into observation group (42 cases) and control group (43 cases).were treated with sustained-release tablets paliperidone and risperidone tablets monotherapy two months.Measuring body mass index before and after treatment (BMI),waist circumference (waist),triglyceride (TG),high density lipoprotein (HDL),fasting plasma glucose (FPG),2 h glucose after OGTT (2 h PG),Positive and Negative Syndrome scale (PANSS) for efficacy evaluation.Results Comparison minutes before treatment PANSS total score and factors,the difference was not statistically significant.After treatment,PANSS total score and factor scores,the difference was not statistically significant.Compared with the previous treatment,both groups PANSS total score and factor scores were significantly decreased after treatment,the difference was statistically significant (P < 0.05).Two groups of patients before treatment indexes,the difference was not statistically significant.After treatment in the control group TG,former TC,HDLC,LDLC,BMI,and waist circumference with treatment,the difference was statistically significant (P < 0.05);the observation group BMI and waist circumference compared with before treatment,the difference was statistically significant (P < 0.05).After observation group TG,TC,LDLC,BMI and waist circumference were significantly lower than the control group,HDLC significantly higher,the difference was statistically significant (P < 0.05).Two FPG,2hPG,SBP and DBP,the difference was not statistically significant (P > 0.05).Adverse reactions in patients in the observation group were significantly lower than the control group,the difference was statistically significant (P < 0.05).Conclusion The sustained-release tablets paliperidone and risperidone female first-episode schizophrenia patients have the same effect,but paliperidone extended release tablets in female patients improve blood lipids,BMI and waist circumference is superior to risperidone.
2.Acupuncture at Dazhui (GV 14) and Geshu (BL 17) for 39 cases of leucopenia.
Yujie WANG ; Zhongshu ZHU ; Wenxiao YANG
Chinese Acupuncture & Moxibustion 2016;36(1):6-6
Acupuncture Points
;
Acupuncture Therapy
;
Adolescent
;
Adult
;
Aged
;
Female
;
Humans
;
Leukopenia
;
therapy
;
Male
;
Middle Aged
;
Young Adult
3.The value of dual-source CT perfusion imaging in evaluation of rabbit liver fibrosis
Hao WANG ; Fan TAN ; Wenxiao JIA ; Hong WANG ; Yunling WANG
Journal of Practical Radiology 2014;(4):675-678
Objective To investigate the value of dual-source CT perfusion imaging in evaluation of liver fibrosis stage.Methods Liver fibrosis models were established with 35 rabbits (experimental group)which were intraperitoneally injected with carbon tetra-chloride.Meanwhile,other 5 rabbits were regarded as control group which were intraperitoneally inj eced with physiological saline.7 rabbits of experimental group and 1 of control group were undergone dual-source CT perfusion scan at 4,6,8,10,12 weeks respec-tively.Arterial liver perfusion (ALP),portal venous perfusion (PVP),total hepatic perfusion (THP),hepatic perfusion index (HPI)were recorded,and staging of liver fibrosis were assessed by pathological method.Results With the increase of liver fibrosis degree,HPI showed an upward trend,whereas PVP was opposite.HPIs of S2,S3 and S4 stage were significantly different com-pared to that of control group respectively.The differences of HPI between S3,S4 stage to S0 and S1 stage were significant.PVP between S2,S3,S4 stage to S0 stage and S1 stage were also significant different.Conclusion HPI and PVP can reflect the perfu-sion changes of liver fibrosis stages.Combination of HPI and PVP may help the diagnosis of S2,S3 or S4 stage of liver fibrosis.
4.Application of MR PROSET Technique in Diagnosing Spinal Nerve Roots Diseases
Hong WANG ; Hao WANG ; Wenxiao JIA ; Jingxu MA
Chinese Journal of Medical Imaging 2010;(1):29-31
Purpose To investigate the clinical value of MR PROSET technique in showing and diagnosing in lumbarsacral nerve root diseases.Materials and Methods Conventional MRI sequence and PROSET sequence coronal images were performed in lumbosacral nerve roots of 15 healthy volunteers and 47 low back pain patients,each case performed 3D maximum intensity projection (3D MIP) post-processed.Spinal nerveroots were observed.Results The PROSET could show dura,dura sheath,spinal nerveroot,ganlias,segments of the nerves posterior to the ganglions well and could be observed from multiple aspects by the 3D MIP.Among the 47 cases of luber nerve root disease,PROSET could show the level of the invasion and compression to the ganglias.Conclusion According to the PROSET technique and conventional MRI picture,can provide the satisfied proof to the diagnosis of lumbosacral nerve root diseases.
5.Fragmentation behaviors of taxanes drugs using electrospray ionization with quadrupole time-of-flight mass spectrometry.
Wenxiao MA ; Hao WANG ; Tingting WANG ; Yan YANG ; Jingkai GU
Acta Pharmaceutica Sinica 2013;48(12):1812-6
The fragmentation pathways of two taxanes drugs have been studied in positive ion mode by Q-TOF with the advantages of high mass accuracy and high resolution analysis. The [M+H] + ions were observed by ESI-MS, from which the molecular weights were obtained. Using the protonated pseudo-molecular ions [M+H]+ as internal reference compounds, the accurate mass and element composition of the fragment ions were determined. The collision induced dissociation (CID) data of the [M+H] ions provided fragmentation pathways of related compounds. Results showed that the major cleavage pathways of paclitaxel and docetaxel were the same that the cleavage of C-O bond between the side chain and taxol skeleton easily occurred, then stripping of the functional groups on the parent ring. Some common fragments were formed, such as m/z 105.033 7, 291.137 3, 309.148 5, 327.159 7, 387.181 2 and 509.217 4, which would provide a basis for future qualitative and quantitative analysis of taxanes in vitro and in vivo.
6.Investigation of the status quo of on-the-job training of head nurses in Shandong Province
Hong LYU ; Wei WANG ; Wenxiao WANG ; Zhenxiang LI
Chinese Journal of Practical Nursing 2014;30(9):46-50
Objective To investigate the status quo and existing problems in 2A or higher level general hospitals in Shandong Province,in order to provide information for establishing and perfecting the head nurse training system of Shandong Province.Methods 666 head nurses from 129 hospitals were investigated by a self-designed questionnaire,namely The questionnaire of status quo of head nurse training in 2A or higher level general hospitals in Shandong Province.Results The head nurses participating in the survey were average (40.1±5.8) years old,66.7% of whom had intermediate titles,78.8% with vocational school as basic education,86.8% with bachelor as the highest degree.The head nurse training contents were mainly level hospital evaluation (73.9%),quality of nursing management training (65.8%) and nursing quality control (64.2%); training forms were mainly seminar (63.7%),conference (51.4%)and short-term training courses (40.5%); cumulative training time was within two weeks; 73.8% of the teachers derived from clinical nursing specialist.79.3% of the head nurses did not attend personalized evaluation before training,while 54.7% received different forms of evaluation after training.57.2% of the head nurses considered there had been problems in previous training,such as less practical knowledge (64.1%),a single mode of training (50.7%),lack of pertinence (34.6%),training teachers level was uneven (32.2%).Conclusions The systematic,hierarchical,normal,required,flexible-form,effective-evaluation and talents head nurse training system should be established to improve the nursing management level of the head nurse fundamentally.
7.Clinical Application of Magnetic Resonance Hydrography in Diagnosing Cystic Echinococcosis
Jian WANG ; Wenxiao JIA ; Hong CHEN ; Miriguli SHAYITI
Journal of Practical Radiology 2000;0(12):-
Objective To investigate the clinical application of magnetic resonance hydrography(MRH) in diagnosing cystic echinococcosis(CE).Methods 47 cases with CE were proved by surgery and pathology.All cases were examed by MRI and MRH.Results Among the 151 lesions in 47 cases,the sensitivity and specificity in diagnosis of CE were 61.59% and 93.33% for MR imaging,92.05% and 86.67% for MRH,respectively.Conclusion The detecting rate of MRH was significant high than that of MRI,MRH combined with MRI has more advantages in diagnosis of CE.
8.Clinical Application of 3D Contrast-enhanced Moving-bed MRA in Arterial Diseases of Lower Extremities
Wenxiao JIA ; Yanling ZHOU ; Jian WANG ; Lixia YANG
Journal of Practical Radiology 1996;0(04):-
0.05). Conclusion Comparedwith DSA and operation,there is excellent correlation among 3D contrast-enhanced moving-bed MRA,DSA and operation.MRA canaccurately and entirely assess occlusive disease of the arteries of the lower extremity.It is a ono-invasive,reliable and potential newtechnique.
9.Analysis of colonoscopy surveillance in 5-year follow-up after polypectomy of non-advanced colorectal adenoma
Wenxiao DONG ; Mengque XU ; Hailong CAO ; Meiyu PIAO ; Bangmao WANG
Chinese Journal of Digestive Endoscopy 2016;33(3):140-144
Objective To assess the results of colonoscopy surveillance in 5 years after polypectomy of non-advanced colorectal adenoma and to identify its risk factors. Methods Patients undergoing colonosco-py and followed up with colonoscopy within 5 years between January 2003 and December 2013 were retro-spectively analyzed.No substance or only small quantity of clear water left in the intestinal tract and colono-scopes accessing ileocecus were regarded as complete examination. The initial colonoscopy was regarded as the baseline colonoscopy. Patients with non-advanced adenomas were assigned to the case group and those without were to the control group. Data of clinical characteristics and colorectal findings were estimated and risk factors were identified. Results A total of 828 patients were included,374 patients in the case group and 454 in the control group on baseline colonoscopy.The case group had a low incidence of advanced adeno-mas at a 1 to 5 years interval when compared with the control group,both with adequate baseline examination [1. 5%(5/ 326)VS 2. 2%(9/ 408),P = 0. 51]. The detection rates of advanced adenomas on follow-up colonoscopy at 1 to 3 years and 3 to 5 years in case group were 1. 7%(3/ 178)and 1. 4%(2/ 148),respec-tively(P>0. 05).Regression analysis showed age≥50 years old and being male were the independent risk factors for advanced adenomas recurrence within 5 years follow-up. No colon cancer was found in 828 patients during the follow-up. Conclusion Surveillance colonoscopy intervals within 5 years is of little benefit to pa-tients who had adequate polypectomy. Too early reexaminations due to concerns about advanced adenomas recurrence can be avoided.
10.Effects of Drug-containing Serum of Ficus Hirta on Oxidative Damage of Spleen Lymphocyte in Aged Mice
Jie YANG ; Dongfeng WEI ; Wenxiao WANG ; Weidong CHENG
Chinese Journal of Information on Traditional Chinese Medicine 2016;(1):52-55
Objective To study the effects of drug-containing serum of Ficus Hirta on oxidative damage of spleen lymphocyte due to aging in aged mice; To discuss its mechanism of action.Methods Forty aged mice were randomly divided into control group and high-, medium- and low-dose Ficus Hirta groups. Control group was given 0.9% sodium chloride solution for gavage, while high-, medium- and low-dose Ficus Hirta groups were given 6.6, 4.4, and 2.2 g/kg aqueous extract of Ficus Hirta for gavage. The spleen index was observed for optimum dose in aged mice. The optimum time and dilution of drug-containing serum of Ficus Hirta were confirmed by MTT method in lymphocyte proliferation test. The positive rate of senescent cells, the activity of T-SOD and the contents of MDA and ROS were determined in cellular antioxidant experiment after treated by optimal drug-containing serum for 48 h. Results Compared with the control group, the spleen index was significantly improved in high-, medium- and low-dose Ficus Hirta groups (P<0.05,P<0.01). 20% drug-containing serum of Ficus Hirta cultivated for 48 h had the best effects on lymphocyte proliferation in aged mice. 20% drug-containing serum of Ficus Hirta could significantly decrease the positive rate of senescent cells (P<0.01), improve T-SOD activity and decrease the contents of MDA and ROS (P<0.05,P<0.01).Conclusion The drug-containing serum of Ficus Hirta can improve the proliferative activity of spleen lymphocyte in aged mice and the mechanism of action may be involved in decreasing the positive rate of senescent cells and increasing antioxidant ability of lymphocyte.