[Objective] To observe the therapeutic effect of Shuangping San in treating mycoplasmal pneumonia (MP)in children. Shuangping San is a prescription composed of modified yupingfeng San, Sijiuzi Tang and Sini San, whichhas the actions of strengthening spleen and lung, replenishing Qi and consolidating exterior a11d soothing liver andregulating spleen. [Methods] Ninety-eight cases of MP were randomized into control group (n= 48) and treatmentgroup (n = 50). The control group was treated with erythromycin and the treatment group with erythromycin andShuangping San. Therapeutic effect, incidence of toxic and side reaction induced by erythromycin and incidence of post-infection spleen-deficiency syndrome were observed in the two groups. [ Results] Therapeutic effect was better,incidence of toxic and side reaction induced by erythromycin and incidence of post-infection spleen-deficiency syndromewere lower in the treatment group than those in the control group (P