Objective To investigate the clinical characteristics of fundic gland polyps (FGPs).Methods Data of patients with FGPs diagnosed from January 2005 to May 2010 were collected and retrospectively analyzed.Results A total of 485 patients were found to have FGPs during routine upper endoscopy,accounting for 0.6％ of total upper endoscopy examinations at the same time period.It was most frequently seen in middle aged females.Clinical symptoms included abdominal distention and discomfort ( 182/485,37.5％ ),gastroesophageal reflux symptoms ( 83/485,17.1％ ) and upper abdominal pain (102/485,21.0％ ).51.3％ (249) of the polyps were located at fundus and 168 (34.6％ ) were at corpus,with most of FGPs (62.3％,302/485) were single polyp with broad base (less than 5mm),and 22.7％ (110/485 ) were multiple ones scattering throughout the fundus.The pathology typically showed cystic lesions in the fundic glands,with dysplasia in 8 and intestinal metaplasia in 3,accompanied by duodenal polyps in 11 and gastric cancer in 1.H.pyloriinfection was detected in 47.8 ％ subjects which was similar to the rate of general population (56.1％ ) in the same period (P =0.422 ).In addition,immunohistochemisty staining for adenomatous polyposis coli and cyclooxygenase-2 was performed in 12 patients,which showed all polyps were positive for adenomatous polyposis coli and 9 of them were cyclooxygenase-2 positive.Conclusion FGPs may not be correlate to H.pyloriinfection.It can be accompanied by dysplasia,intestinal metaplasia and duodenal polyps.Pathological and immunohistochemical studies may promote a better understanding and standardized diagnosis and treatment for this disease.

Objective To evaluate the effectiveness of M2A capsule endoscopy in the diagnosis of obscure gastrointestinal bleeding of elder patients. Methods Capsule endoscopy was used in 27 elderly patients, who were suspected of small bowel bleeding because of obscure gastrointestinal bleeding. About 20 of the 27 patients underwent gastroscopy, colonoscopy or air-baricum double contrast examination, but none of the examinations confirmed the bleeding sites, whereas the other 5 patients didn't receive any examination because of their intolerance. Results M2A capsule endoscopy disclosed the sites of small bowel disorders in 20 out of the 27 patients, the positive rate was about 74. 1%. The pathological findings consisted of angiodysplasia in 6 cases, mutipolypi in the intestine in 4, and 1 of them was diagnosed rare Cronkhite-Canada syndrome, prominency in the intestine in 4, single or multiple ulcers in the intestine in 7, diffuse mucosa lesion in the intestine in 9 and diverticulum in 1, arteriolar bleeding in gastric in 2, gastric mucosa erosion or ulcer in 5, whereas 7 patients were in negative findings. There were 12 patients in whom appeared at least 2 sites of pathological changes. Conclusions This study demonstrates that capsule endoscopy provides an excellent visualization way for the small intestines, especially when the elder patients suffers obscure gastrointestinal bleeding. It is safe and usefull for evaluating the suspected small bowel bleeding.

Objective To investigate the effect of berberine on inhibiting HT-29 human colon cancer cell proliferation induced by deoxycholic acid(DCA).Methods The berberine with concentration of 1,5,10 or 20?mol/L were added into the HT-29 human colon cancer cell culture media containing 200?mol/L DCA.The effects of berberine on cell proliferation were studied by the method of MTT.RT-PCR was applied to measure the expression of cyclooxygenase-2(COX-2)mRNA.Cellular immunochemical stain was applied to label COX- 2 protein expression.Concentration of prostaglandin E2(PGE2)was measured by radioimmunoassay. Results HT-29 cells were incubated with DCA for 6 h,COX2 expression of cells were increased prominent compared to controls(65.5%?5.6% vs.6.2%?1.1%).The level of PGE2 were increased(24.1 ng/L?1.4 ng/L vs.10.6 ng/L?0.8 ng/L).One?mol/L berberine reduced the proliferation rate of HT-29 in- duced by DCA over 6 h,the proliferation rate was 7.4?3.5%.Both COX-2 mRNA expression and the level of PGE2 were inhibited when the concentration of berberine was over 1?mol/L,and in a concentration-time dependent manner.Conclusions Berberine can inhibit the proliferation of HT-29 human colon cancer cell in- duced by DCA.Berberine can also suppress the expression of COX-2,and decrease the production of PGE2. These data provide new insights into the mechanism of its anti-cancer properties.

Objective To measure the peripheral dose distributions of the mobile head cone beam computed tomography (CBCT) and evaluate the impact of CBCT on the surrounding personnel and environment, and provide data support for clinical radiation protection management. Methods Combined with the structural characteristics of CBCT, AT1123 was used in the direction of 0° (counterclockwise), 45°, 90°, 135°, 180°, 225°, 270° and 315° in front of CBCT to measure the ambient dose equivalent rate of 30 cm, 80 cm and 130 cm away from the ground when the equipment was normally out of the beam, and the boundary of the temporary control area was drawn. At the same time, the dose level behind the lead screen 1 m away from the external surface of the equipment was measured and analyzed. Results The dose field around CBCT was symmetrically distributed with the dividing line of 0° and 180°, and the radiation dose level of 5.5 m in the direction of 0°, 3.5 m in the direction of 45°, 0.5 m in the direction of 90° and within 1.0 m in the direction of 180° (inside the "spoon" type) was higher than 2.5 μSv/h. The radiation dose levels of CT aperture 0° (straight forward), 45° and 315° behind the lead screen 1 m away from the equipment surface were 0.37 μSv/h, 0.22 μSv/h and 0.54 μSv/h, respectively. Conclusion The results show that the radiation dose around the mobile head cone beam CT is in a low dose level, the distribution of the dose field can provide necessary reference for the administrative and medical personnel to strengthen the radiation safety management. At the same time, it is suggested that lead screens should be set up in the clinical use of mobile CT to ensure the health and safety of the surrounding people and the environment.