Purpose:To validate further the importance of r adiotherapy following breast-conserving surgery in early breast cancer. Methods:From 1994.12 to 2001.12,237patients with early stage breast can cer were treated Of these patients,eighty-three received breast-conserving surgery followed by radiotherapy,and one hundred and fifty-four received modified radical mastectom y.All patients with breast-conserving surgery underwent postoperative radiother apy.The range of radiation dose depends on the size,location of tumor,and involv ement of axillaty nodes.Tangential chest wall fields delivered 5000cGy with 8MV -X ray beam in 5 weeks .An additional 1500cGy was delivered in 8 days to tumor bed with electron beam.Among the patients with modified radical mastectomy.only 3 received postoperative radiotherapy.Results:In both the breast-conserving surgery group and modified radical mastectomy gro up,one patient recurred regionally,and one died respectively .In the modified ra dical mastectomy group,there were no regional lymph nodes recurrence,but two of them had distant metastasis.The 5year survival of the two groups were 96.49%and 98.61%,respectively.The breasts are soft and resilient in the breast-conserving surgery group,and breast shape whole after surgery.Conclusions :Breast-conserving surgery plus postoperative radiotherapy in early breast can cer can obtain treatment results similar to modified radical mastectomy,with goo d cosmetic

ObjectiveTo describe utilizations of maternal health care in migrant maternity in Putuo District and to identify the gap between primipara and multipara.In order to improve utilizations of Maternal Health Care in migrant maternity.MethodsQuestionnaire survey was carried out among lying-in migrant maternity to obtain information on utilization of maternal health care.Database was established the by Epidata 2.1 and Statistical analyzed by SPSS11.0.ResultsThere was significant difference between multipara and primipara in age,household registration and cultural degree(P＜0.01 ).Women registered at early stage of the pregnancy with 50.51％,completed full pre-natal health check-up with 82.83％,received postnatal visits with 78.45％ in migrant maternity.There was significant difference between multipara and primipara in registered at early stage of the pregnancy,full pre-natal health check-up,received the postpartuu visit,registered at first level hospital and the medical insurance coverage in migrant maternity(P＜0.01 ).ConclusionsThe levels of utilizations of maternal health care in migrant maternity in putuo district are significantly lower than local maternity,the levels of utilizations of maternal health care in multipara are lower than primipara in Putuo district.Improve utilizations of maternal health care in multipara and enhance utilizations of maternal health care in migrant maternity in Putuo district.

OBJECTIVETo evaluate the short-term efficacy and long-term preventive effect on recurrence in prevention and treatment of children allergic rhinitis treated with the multiple therapy at Dazhui (GV 14) as the main acupoint and acupoint plaster therapy.

METHODSOne hundred and twenty cases of children allergic rhinitis were randomized into a triple-strong stimulation therapy group and an acupoint plaster therapy group, 60 cases in each one. In the triple-strong stimulation therapy group, Dazhui (GV 14) was the main acupoint, combined with one of Feishu (BL 13), Zhiyang (GV 9) and Shenshu (BL 23) accordingly. The heavy needling technique was adopted with the three-edged needle, followed by heavy cupping and heavy moxibustion. The treatment was given once every 3 days, continuously for 10 times. In the acupoint plaster therapy group, the acupoints selected were same as the triple-strong stimulation therapy group. The self-prepared Chinese herbal plaster was used, 4 h to 8 h each one time, once every 3 days, continuously for 10 times. The changes in the symptom and physical sign scores were observed before treatment, after treatment and in 6 months follow-up visit after treatment in the two groups. The clinical efficacy was compared between the two groups.

RESULTSAfter treatment and in 6 months follow-up visit after treatment, the symptom scores, physical sign scores and symptom scores of each item were different signi ficantly as compared with those before treatment in the triple-strong stimulation therapy group (P<0.01, P<0.05), and the results in the triple-strong stimulation therapy group were better than those in the acupoint plaster therapy group (all P<0.01). In 6 months follow-up visit, the total effective rate was 94.6% (53/56) in the triple-strong stimulation therapy group and was 25.9% (15/58) in the acupoint plaster therapy group, indicating the significant difference (P<0.001).

CONCLUSIONThe triple-strong stimulation therapy at Dazhui (GV 14) achieves the superior effect on the prevention and treatment of children allergic rhinitis as compared with the acupoint plas ter therapy and has good long-term effect of the prevention from recurrence.

Acupuncture Points ; Acupuncture Therapy ; Adolescent ; Child ; Combined Modality Therapy ; Female ; Humans ; Male ; Moxibustion ; Rhinitis, Allergic ; prevention & control ; therapy

Objective To analyze the association of polymorphisms of estrogen receptor (ER) α and β genes with systemic lupus erythematosus (SLE) in Chinese Han cohort of Yunnan Province.Methods XbaⅠ and Pvu Ⅱ of ERα gene,Rsa Ⅰ and Alu Ⅰ of ERβ gene were typed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 697 SLE patients and 638 healthy controls.The frequency distribution of the alleles and genotypes were analyzed by Hardy-Weinberg equilibrium test and x2 test.Results ① For ERα gene,the frequency of minor allele of Pvu Ⅱ C in SLE patients was significantly higher than healthy controls (x2=15.427,P=0.001);the allele frequencies of XbaⅠ in SLE patients showed no significant difference compared with healthy controls (P＞0.05).The frequency of minor genotype of Pvu Ⅱ CC in SLE patients was significantly higher than healthy controls (x2=17.371,P=0.011).The frequency of two locus haplotype AATT in SLE patients was significantly lower than healthy controls (x2=6.333,P=0.012);the frequency of the two locus haplotype AACC in SLE patients was significantly higher than healthy controls (x2=7.771,P=0.038).② For ERβ gene,the frequency of minor allele RsaⅠ A in SLE patients was significantly lower than healthy controls (x2=12.595,P=0.013);the allele frequencies of Alu Ⅰ in SLE patients showed no significant differences compared with the healthy controls (P＞0.05).The frequency of minor genotype AA of Rsa Ⅰ in SLE patients was significantly higher than healthy controls (x2=41.456,P=0.000).The frequency of two locus haplotype AAGG in SLE patients was significantly higher than healthy controls (x2=37.063,P=0.000).The frequency of the two locus haplotype AAGA in SLE patients was significantly lower than healthy controls(x2=21.086,P=0.001).③ Pvu Ⅱ C was related with splenomegaly (x2=4.212,P＜0.05).The two locus haplotype AGTC of Xba Ⅰ and Pvu Ⅱ was related with edema (x2=7.898,P＜0.05).Conclusion There are associations between the polymorphisms of ERα and ERβ genes and SLE.The ERα and ERβ genes may be the susceptible genes for SLE in Yunnan Han Chinese Cohort.

0.05).Conclusions:Combined anchorage can provide maximum anchorage compared with traditional face bow and was accepted easily by patients.

Purpose:To evaluate the feasibility of dose escalation in non small cell lung cancer(NSCLC) treatment using 3 dimensional conformal radiotherapy and to assess the immediate responses and acute side effects.Methods:25 patients with inoperable NSCLC were evaluated from October 2000 to July 2001. Conventional irradiation technique was used until the tumor dose reached 40 41.4Gy. FOCUS2.6.1 of CMS three dimensional treatment planning system(3D TPS) was used to design the dose escalation treatment plan and DVHs was used to optimize it.The planning target volume (PTV)encompassed 1 1.5cm outside the clinical target volume(CTV).The irradiation doses of dose escalation treatment plan ranged from 25Gy to 30Gy,and were delivered in daily fractions of 2.5 3 Gy,5 days a week. WHO criteria and RTOG/EORTC grading scheme were used to assess the immediate responses and acute side effects.Results:All 25 patients completed the treatment successfully. The median radiation dose to the gross tumor volume(GTV) was 7012cGy(62 45 Gy 71 40 Gy).The overall immediate response rate (CR+PR)was 72.0%(18/25). According to the RTOG grading scheme , acute radiation esophagitis occurred in 24.0%(6/25)of patients with Grade 1 2 and 4.0%(1/25)with Grade 3 respectively. Acute radiation pneumonitis occurred in 16.0%(4/25)of patients with Grade 1 2 and 4.0%(1/25)with Grade3 respectively. The bone marrow toxicity occurred in 16.0%(4/25)with Grade 1 2. Damage to the heart occurred in 12.0%(3/25) with grade1 2. Median follow up is 14 months.Conclusions:Dose escalation in NSCLC treatment using 3 dimensional conformal radiotherapy has an encouraging immediate response rate with lower acute complication. Late side effects of irradiated and survival will be observed. [

Biomedical Research ; Clustered Regularly Interspaced Short Palindromic Repeats ; Humans

Electrical impedance tomography (EIT) is a technique for reconstructing the conductivity distribution of measured field owing to its characteristics of being non-homogeneous, of injecting current at the boundary of the measured subject,of measuring the.corresponding changes in voltage, and of reconstructing the image of the subject consequently. However, the limited measurement data of EIT, and the serious nonlinearity of the field result in ill-posed problem, and the resolution of reconstructed image is poor. To solve the problem, a new hybrid algorithm is herein proposed. The method combines the characteristics of Krylov subspace and Tikhonov regularization, which can improve the real time performance, the quality and robustness of reconstructed image.
Algorithms ; Electric Impedance ; Humans ; Image Processing, Computer-Assisted ; methods ; Tomography ; methods