Objective To investigate the rehabilitation effect of folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage on treatment of patients with high-risk diabetic foot (DF).Methods A total of 120 patients with high-risk DF were randomly divided into 4 groups.The control group was given routine therapy of diabetes.Besides the basic treatment,folic acid was given in the folic acid group.On the basis of the folic acid group,lipoic acid was used in lipoic acid group with oral taken after two weeks of intravenous drip.The massage group was treated with plantar acupoint massage on the basis of the lipoic acid group,and the treatment course was 6 months.The Toronto symptom and sign score,the brachial ankle pulse wave velocity (baPWV),the ankle brachial ratio (ABI) and the score of life quality of four groups were compared before and after the intervention.Results The homocysteine and the baPWV in the folic acid group,the lipoic acid group and the massage group were significantly lower than those in the control group (P ＜0.01).Except for the folic acid group,The Toronto symptom and sign score in the other two groups was significantly lower than that in the control group (P ＜ 0.01).Except for the folic acid group,ABI of the lipoic acid group and the massage group was significantly higher than that of the control group (P ＜0.01).The score of life quality in the lipoic acid group and the massage group were significantly lower than that in the control group (P ＜ 0.01).The oxidized low density lipoprotein in the lipoic acid group and the massage group were significantly lower than that in other two groups (P ＜ 0.01).Conclusion Folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage can improve the effect of DF patients.

Objective To analyze the dynamic changes in serum adiponectin(APN)levels after acute myocardial infarction(AMI)and its relationship with heart failure(HF)and major adverse cardiovascular events(MACE).Methods A total of 124 AMI patients who underwent percutaneous coronary intervention(PCI)in our hospital from January 2021 to December 2023 were enrolled as AMI group.Additionally,30 patients with non-AMI coronary artery disease and 30 healthy individu-als were included in non-AMI coronary artery disease group and healthy group,respectively.General information such as age,gender,smoking,alcohol consumption,hypertension,diabetes,and blood lipids were recorded for all subjects.Serum APN levels were measured using the enzyme-linked im-munosorbent assay(ELISA)method;plasma brain natriuretic peptide(BNP)levels were determined by immunofluorescence;and left ventricular ejection fraction(LVEF)was assessed using echocardio-graphy.Changes in serum APN levels and its relationship with BNP,LVEF,and MACE were recor-ded during a one-year follow-up period.Results AMI patients had lower serum APN levels than those in the non-AMI coronary artery disease group and the healthy group,while levels of total choles-terol(TC),low-density lipoprotein cholesterol(LDL-C);Lipoprotein-associated phospholipase A2(Lp-PLA2),and the proportions of smokers and diabetics were higher(P＜0.05).A one-year follow-up of AMI patients revealed an upward trend in serum APN and BNP levels and a downward trend in LVEF levels at one week,one month,three months,six months,and one year postoperatively(P＜0.05).APN and BNP levels peaked one month after PCI,while LVEF reached its lowest level at the same time point.However,there were no statistically significant changes in these indicators in the subsequent 11 months(P＞0.05).The incidence of MACE in AMI patients at one,three,six,and twelve months postoperatively was 2.8％,3.2％,4.6％,and 8.8％,respectively.Both preoper-ative and one-month postoperative serum APN levels had high predictive value for the occurrence of HF and MACE within one year in AMI patients,and the area under the curve for predicting HF and MACE one month postoperatively was larger than that preoperatively(P＜0.05).Conclusion Ser-um APN levels in AMI patients show an upward trend after PCI,peaking one month postoperatively.At this time point,serum APN levels have the highest predictive value for the occurrence of HF and MACE.

Objective To investigate the rehabilitation effect of folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage on treatment of patients with high-risk diabetic foot (DF).Methods A total of 120 patients with high-risk DF were randomly divided into 4 groups.The control group was given routine therapy of diabetes.Besides the basic treatment,folic acid was given in the folic acid group.On the basis of the folic acid group,lipoic acid was used in lipoic acid group with oral taken after two weeks of intravenous drip.The massage group was treated with plantar acupoint massage on the basis of the lipoic acid group,and the treatment course was 6 months.The Toronto symptom and sign score,the brachial ankle pulse wave velocity (baPWV),the ankle brachial ratio (ABI) and the score of life quality of four groups were compared before and after the intervention.Results The homocysteine and the baPWV in the folic acid group,the lipoic acid group and the massage group were significantly lower than those in the control group (P ＜0.01).Except for the folic acid group,The Toronto symptom and sign score in the other two groups was significantly lower than that in the control group (P ＜ 0.01).Except for the folic acid group,ABI of the lipoic acid group and the massage group was significantly higher than that of the control group (P ＜0.01).The score of life quality in the lipoic acid group and the massage group were significantly lower than that in the control group (P ＜ 0.01).The oxidized low density lipoprotein in the lipoic acid group and the massage group were significantly lower than that in other two groups (P ＜ 0.01).Conclusion Folic acid,intravenous and oral lipoic acid sequential therapy combined with plantar acupoint massage can improve the effect of DF patients.

Objective To analyze the dynamic changes in serum adiponectin(APN)levels after acute myocardial infarction(AMI)and its relationship with heart failure(HF)and major adverse cardiovascular events(MACE).Methods A total of 124 AMI patients who underwent percutaneous coronary intervention(PCI)in our hospital from January 2021 to December 2023 were enrolled as AMI group.Additionally,30 patients with non-AMI coronary artery disease and 30 healthy individu-als were included in non-AMI coronary artery disease group and healthy group,respectively.General information such as age,gender,smoking,alcohol consumption,hypertension,diabetes,and blood lipids were recorded for all subjects.Serum APN levels were measured using the enzyme-linked im-munosorbent assay(ELISA)method;plasma brain natriuretic peptide(BNP)levels were determined by immunofluorescence;and left ventricular ejection fraction(LVEF)was assessed using echocardio-graphy.Changes in serum APN levels and its relationship with BNP,LVEF,and MACE were recor-ded during a one-year follow-up period.Results AMI patients had lower serum APN levels than those in the non-AMI coronary artery disease group and the healthy group,while levels of total choles-terol(TC),low-density lipoprotein cholesterol(LDL-C);Lipoprotein-associated phospholipase A2(Lp-PLA2),and the proportions of smokers and diabetics were higher(P＜0.05).A one-year follow-up of AMI patients revealed an upward trend in serum APN and BNP levels and a downward trend in LVEF levels at one week,one month,three months,six months,and one year postoperatively(P＜0.05).APN and BNP levels peaked one month after PCI,while LVEF reached its lowest level at the same time point.However,there were no statistically significant changes in these indicators in the subsequent 11 months(P＞0.05).The incidence of MACE in AMI patients at one,three,six,and twelve months postoperatively was 2.8％,3.2％,4.6％,and 8.8％,respectively.Both preoper-ative and one-month postoperative serum APN levels had high predictive value for the occurrence of HF and MACE within one year in AMI patients,and the area under the curve for predicting HF and MACE one month postoperatively was larger than that preoperatively(P＜0.05).Conclusion Ser-um APN levels in AMI patients show an upward trend after PCI,peaking one month postoperatively.At this time point,serum APN levels have the highest predictive value for the occurrence of HF and MACE.