Objective To solve the problem about abundance information but poverty of knowledge by training the information analysis ability of users.Objects Medical graduate students who have the basic knowledge of literature retrieval.Curriculum Bibliometric parameters,reference management software,literature analysis software,Excel and the analysis function of bibliographic database were explained in 18 class hours.Results Satisfactory results have been got.Discussion Users can analyze retrieval results effectively after short time learning with no additional cost.

OBJECTIVE: To bring forward feasible suggestions for Direct-to-Consumer(DTC) marketing of prescription drugs.METHODS: The importance of analysis of DTC marketing of prescription drugs in solving "unrealistically high" drug price because of asymmetric information and its role in sufferers' participating in self-health care were analyzed.The status quo and the problems faced in US DTC marketing were also analyzed.RESULTS & CONCLUSIONS: The marketing of prescription drugs can be extended to the sufferers in China,but we must pay attention to the checkup for DTC advertisement,the time of DTC advertisement being forbidden after the new drugs launched into the market and the scope for DTC marketing.

In order to reduce the impact of various noise in pulse signal, the quality estimation and filtering algorithms based on cyclostationarity are proposed to reprocess pulse signal. First, A quality evaluation index of pulse signal which named quality factor is defined by cyclic spectrum to describe the quality variation of the pulse signal affected by noise; Second, a cyclic correlation matched filter (CCMF) is designed to remove noise. The simulation of pulse signal is produced by ourselves and noise signal is provided by MIT-BIH physiological database are used to test the function of proposed method, and then the method is applied to the actual pulse signal. The results show that the quality factor can accurately reflect the quality of the pulse signal and the CCMF can effectively remove noise from pulse signal.
Algorithms ; Databases, Factual ; Heart Rate ; Humans

This article introduces the customized information service,including its emergence,characteristic,contents as well as the way by which it is achieved.And then the process is explained by giving the demonstration of RSS customized information service provided by PubMed system.

A competency dictionary of advanced health informatization application persons was compiled by inter-viewing 20 health information persons with behavior events interview , their competency characteristics were coded By Nvivo, the coding frequency and characteristics score in good performance group and ordinary group were ana-lyzed by variance analysis, which showed 8 characteristics of key competency and 12 characteristics of basic compe-tency in advanced health information application persons.

As society develops,it has become one of the important goals of higher medical personnel training to cultivate medical students' information literacy.After explaining the definition of information literacy,this paper discussed the importance of information analysis and evaluation in information literacy education.

In order to enrich postgraduates’ knowledge of medical literature retrieval,consolidate classroom teaching,and strengthen the communication between the students and the teachers.this paper put forward a new ideas about postgraduate medical literature retrieval teaching,discussed its role,and applied it to practical teaching.

The article discusses reforming information search course, integrating the education of users training and information search course for training the persons with ability of innovation or scientific research in new century, strengthening the combination of theory and practice, reforming the way of exams, emboding the individuation in teaching amd strengthening the ability of information analysis and catch .

Charged particle therapy offers a better effect and obvious dosimetric and biological advantages over conventional radiotherapy in tumor control.Charged particles form Bragg peak in the dose distribution in tissue, enable most of energy to be deposited in the target region, and thus enhance tumor control and reduce the damage to normal tissues surrounding the tumor.With the increasing demand for charged particle therapy and the advances in particle accelerator, particle therapy technology is developing rapidly.The core apparatus of particle therapy facility is particle accelerator, and the accelerator type, particle type, and implementation technique determine the performance and therapeutic effect of the facility.This article provides a detailed comparative analysis of various particle therapies.Statistical data show that proton therapy is dominant in particle therapy, and high construction difficulty, large facility size, and extremely high cost have limited the development of heavy ion therapy.Nowadays, there are still some technical problems regarding charged particle therapy, and more clinical trials are required.

To explore a new strategy for further optimization to the C-3 bioisteric heterocyclic ring of fluoroquinolones,twelve novel fluoroquinolone C-3 s-triazole Schiff-base carboxylic acid derivatives(7a-71) were designed and synthesized with both functionalized sulfanylacetic acid and Schiff-base moieties as the modified side-chain for the C-3 bioisosteric s-triazole ring of pefloxacin(1).The structures were characterized by elemental analysis and spectral data,and the in vitro anti-tumor activity of the title compounds against SMMC-7721,L1210 and HL60 cell lines was evaluated.The preliminary pharmacological results demonstrated that the title compounds possessed more significantly anti-proliferative activity than either the parent 1 or the corresponding amine intermediates(6).In particular,the title compound bearing a fluorine atom (7j) and compound bearing a nitro group attached to benzene ring (71) were comparable to the control doxorubicin against SMMC-7721 cells with an IC50 value of micro-molar concentration,respectively.It suggests that s-triazole ring modified with functional side-chain moieties instead of the C-3 carboxylic group is favorable to the improvement of antitumor activity.