Objective To compare the results of stroke risk assessment system in patients with non-valvular atrial fibrillation u-sing CHADS2 and CHA2 DS2-VASc .Methods A total of 420 patients with non-valvular atrial fibrillation were evaluated using CHADS2 and CHA2DS2-VASc ,they were divided into three groups according scores :low risk group(scores 0) ,intermediate risk group(scores 1) ,high risk group(scores≥2) .Compare the average scores and the proportions of three groups of two stroke risk as-sessment system .Results The average score of CHA2DS2-VASc was significantly higher than that′s of CHADS2 (2 .41 ± 1 .93 vs . 1 .39 ± 1 .39 ,P<0 .05) .According to scores of CHADS2 ,the proportions of low risk groups were 34 .5% (145/420) ,intermediate risk group were 28 .8% (121/420) ,high risk group were 36 .7% (154/420) .According to scores of CHA2DS2-VASc ,the propor-tions of low risk group were 16 .2% (68/420) ,intermediate risk group were 23 .3% (98/420) ,high risk group were 60 .5% (254/420) .CHA2 DS2-VASc compared with CHADS2 ,the proportion of low-risk group significantly lower than the latter ,the proportion of high-risk groups significantly higher than the latter(P<0 .05) .Conclusion The scores of CHA2DS2-VASc is significantly high-er than that′s of CHADS2 in patients with non-valvular atrial fibrillation ,there are more patients needs anticoagulation using stroke risk assessment system CHA2 DS2-VASc .

Cerebral small vessel diseases refer to a group of clinical,radiological,or pathological phenomenas with various aetiologies that affect the small arteries,arterioles,capillaries,venules and small veins of the brain.Patients may manifest as cognitive dysfunction,abnormal gait,and/or dysarthria.Cerebral small vessel diseases can be visualized as lacunar infarcts,white matter lesions,cerebral microbleeds,enlarged perivascular spaces and brain atrophy on neuroimaging studies.Its eiology and pathogenesis are complex and complicated.In the recent years,with advances in molecular genetics and studies on hereditary and sporadic cerebral small vessel diseases,several monogenic conditions involving cerebral small vessels have been identified.Monogenic cerebral small vessel disease is a kind of single-gene inherited disease which manifests clinical spectrums involving multiple systems,and cerebral small vessel disease is a common characteristic.Here,we summarized the inheritance patterns,main clinical findings,neuroimaging findings,pathological features and main geneteic traits in monogenic cerebral small vessel disease,and reviewed the genetics mechanism and advance studies of some common forms of sporadic cerebral small vessel disease.