The KM mice(8=week-old,female)were immunized,i.p.,once a week,with outer membrane protein of ampylobacter jejuni S131.The mice were killed 12 weeks after the first injection.Serumof each mouse was collected or detecting of autoantibodies against double strained DNA,singlestrained DNA and total histones by ELISA ethod.These autoantibodies detected were inducedsuccessfully when the dose was 120-00?g/time/mouse.There was a good relation between dose andeffect.So our experimental odel provided an useful method and a novel pathway to explore theetiology and mmunological mechanisms of autoimmune diseases on molecular level.In addition,among hese three kinds of autoantibodies,the level of anti-histone antibodies was the highest and hetime it went up was the earliest,this indicated the potential significance for clinic in arlier iagnosisof some autoimmune diseases.