Objective To compare the clinical efficacy of isoket and nitroglycerin in the treatment of coronary heart disease complicated with acute left ventricular failure.Methods 120 cases of coronary herrt disease complicated with acute left ventricular failure were randomly divided into isoket group (observation group) and nitroglycerin group(control group),each group had 60 cases.The clinical efficacy and adverses reactions were compared between the two groups.Results The total effective rate of the observation group was 95.0％,which was significantly higher than 75.0％ of the control group,and the difference was statistically significant(P ＜0.05).The incidence rate of adverse reactions in the observation group was 3.3％,which was significantly lower than 15.0％ of the control group,the difference was statistically significant(P ＜0.05).Conclusion Isoket can significantly improve the clini cal symptoms of coronary heart disease complicated with acute left ventricular failure,and it has lower incidence rate of adverse reactions,which is worth to be further promoted in clinical.