In recent years, with the rapid development of economy and the improvement of people.s lifestyle and level, the incidence of diabetes has been sharply rising. According to the epidemiological survey, 60-75％ of diabetic patients are accompanied by depressive symptoms, and even 10-35％ of them are severely depressed, and the risk of diabetes in depressed patients is twice that of normal people. Diabetes mellitus with depression (DD) seriously affects the quality of patients. life, which has attracted more and more attention. At present, the drugs to treat DD are mainly chemical drugs.Due to the single target, strong drug dependence and obvious side effects, etc., it is a tough problem to be solved urgently in clinical practice to find a treatment drug with multiple targets, low toxicity and little side effects. The research group found that the invigorating qi and nourishing blood formula Danggui-BuxueDecoction (DBD) has a relatively exact effect on DD.