Methylmercury is a potent toxicant, bioaccumulated and concentrated through the aquatic food chain, placing risks to human on the top of the chain. Based on the researches of adverse health effects exposed to methylmercury, several health risk assessment indexes (reference dose, provisional tolerable weekly intake, occupational mercury exposure assessment indexes ) and experiences on methylmercury exposure prevention (mainly on fish consumption) from the developed countries are presented in this paper.

Objective To evaluate the therapeutic effect and mechanism of specific inducible nitric oxide synthase(iNOS)aminoguanidine(AG)in rats with obstructive jaundice.Methods Forty male Wistar rats were divided randomly into four groups: normal control group, sham operation group, obstructive jaundice group and aminoguanidine therapeutic group.Each group had 10 rats.We assayed levels of liver function,hemobilirubin, endotoxin,lactic acid and malondialdehyde before and after therapy, and we also analyzed pathology of the liver and small intestine.Then we could explore the therapeutic effect of AG in rats with obstructive jaundice.Results The levels of endotoxin,lactic acid and malondialdehyde in blood increased progressively along with the pathological changes of the liver and small intestine.Each of the AG group parameters was significantly lower, and the pathological changes of liver and small intestine were improved.Conclusion AG could protect liver and small intestine by attenuating lipid peroxidative and endotoxemia,and provide a new way to cure obstructive jaundice.

As a carrier for MRI contrast agent,active targeting liposome demonstrates distinct advantages in tumor diagnosis and treatment due to its characteristics of biocompatibility,non-toxicity and targeting ability.Tumor targeting imaging with liposome labeled with molecular recognition system,or liposome sensitive to pH value or temperature is a popular research topic.The application of various types of active targeting liposome for tumor magnetic resonance imaging is reviewed in this review.

A highly sensitive fluorescence spectroscopic method was established for the selective determination of estradiol, which took advantages of the excellent molecular recognition capability of aptamer and the energy transfer between the specific fluorescent groups. The effects of the pH value, buffer constituent and concentration, the concentration of DNA, the experimental temperature and response time on the detection of estradiol were studied. Under the optimal conditions (50 mmol/L BR buffer solution with pH value at 7. 4, 1. 0×10-7 mol/L for each DNA strand, incubation at 45 ℃, response time 19 min), the change of the fluorescence intensity (ΔI) versus the logarithm of the concentration of estradiol ( lgC) was linear over a concentration range from 1. 0×10-11 mol/L to 5. 0×10-9 mol/L with good linear correlation (r=0. 9953). The limit of detection (LOD) was found to be 6. 0×10-12 mol/L (S/N=3). This method was successfully applied to the detection of estradiol in human urine, with the recovery in the range of 94. 0%-103. 5%. This method showed good precision and accuracy.

Objective To investigate the posterior condylar angle(PCA) of distal femur in normal adult, and provide reasonable referenced parameters of the rotational alignment for the total knee arthroplasty in Chinese. Methods This study concluded 118 volunteers(186 knees) in Suwan area (67 males 103 knees, and 51 females 83 knees), whose knees were healthy, without any malformation. The average age was 39.7 years(range, 18-69 years). All subjects were divided into three groups according to the ages: group A, 18-39 years (85 knees); group B, 40-59 years(73 knees); group C, more than 60 years(28 knees). The CT scan was employed to the mechanical axis which was perpendicular to the knee joint in the distal femur. The PCA was measured from the CT film across lateral and medial femoral epicondyle. The factorial design was used to compare the data among three groups. Results First, in the 103 knees of male, 57 in left side and 46 in right side. The PCA were 5.9??1.6? in left side, 5.6??2.6? in right side(mean, 5.8??2.2?). Then in the 83 knees of female, 38 in left side and 45 in right side, the PCA was 5.5??2.5? in left side, 5.2??1.5? in right side(mean, 5.3??1.9?). And the PCA was 5.5??1.9? in group A, 5.7??1.8? in group B, 5.5??2.7? in group C, respectively, and there is no statistical significant difference in either gender or side and age. Conclusion The normal adult PCA of distal femur is 5.6??2.1? in Suwan area, without difference in gender, which is beyond the Westerns obviously. So in the total knee arthroplasty of Chinese, the malalignment will likely occur if the rotational alignment is performed according to Western style, the eversion 3? to the posterior condylar line in distal femur.

Objective: To assess the effect of taurine supplementation on behavior of young rats exposed to low-level lead. Methods: Wistar dam rats were randomly divided into three lead+Tau(0.5%, 1.0% ,1.5%)groups, lead group and control group.Dams of three lead+Tau groups were fed with food containing 0.5%,1.0%,1.5% taurine respectively from d 9 of gestation. Lead+Tau groups and lead group dams were given water containing 0.14% PbAc 2 ad lib. from d 16 of gestation to weaning of the off spring on d 25 post partum. The pups continued taking same food and water. The neurobehavioral function of pups was tested. Results: (1) Taurine supplementation could significantly decrease accumulation of lead in the brain of young rats. (2)Taurine supplementation was able to prevent Pb-induced retardation on behavioral development, and also learning and memory damage in young rats.(3) In all selected six brain regions, the content of NA and DA was decreased in lead group compared with control group. The content of NA in all six brain regions and DA in pituitarium, cerebellum and cortex in 1.0% taurine supplementation group could be restored to normal. The content of ACh in hippocampus and cortex was decreased in Lead compared to Cont group, and which could be corrected by Tau supplementation. Conclusion: The results suggest that taurine has protective function against Pb-induced toxicity and can protect the nervous system against Pb-induced damage in the development of young rats.

Growing energy consumption has become a key consideration for hospital infrastructure,while densely-placed data centers in the hospital make things worse.In view of energy saving and environment protection,the authors briefed the inevitable trend and requirements for the hospitals to build environment-friendly data centers,with key details and outcomes covered.

Objective To explore the drugs combined with psychological therapy for lumbar disc herniation, summarize the clinical experience.Methods For 60 cases of lumbar disc herniation were treated with drug therapy, and classified as the control group, the other 60 patients in the control group on the basis of psychological intervention therapy, and classified as the observation group, two groups of patients were in our hospital from January 2016 to January 2017 were treated.Results No significant difference between the two groups of patients before treatment, the pain score, after grouping after the intervention in the observation group were obvious pain relief;compared two groups of patients with the emotional state of the visible, before treatment had no significant difference after The observation group after the intervention group were improved more significantly, shows significant difference(P<0.05).Conclusion The analysis showed that the drugs combined with psychological therapy for lumbar disc herniation, which can help patients to improve the clinical situation, adjust the patient's psychological anxiety and depression, improve the clinical effect of intervention, so it is worthy of reference.

Circulating tumor cells are found in patients’ peripheral blood circulation, which are the key to tumor metastasis and recurrence. We can achieve early diagnosis and treatment of the tumor if we could detect circulating tumor cells through peripheral blood vessels. It is of great significance to improve the prognosis of hepatocellular carcinoma patients by studying the relationships between hepatocellular carcinoma and peripheral circulating tumor cells. Hence, this paper reviews the recent progress in the detection and clinical application of circulating tumor cells in hepatocellular carcinoma in order to provide references for clinical and related studies.

Objective To explore the effect of the transplantation of intact follicle by punching with syringe needle on defect eyebrow reconstruction.Methods Fifty-two patients with eyebrow defects due to burn,trauma,resection and inappropriate eyebrow trimming were recruited,35 with bilateral defects and 17 with unilateral defect.The scalps strips from the safe donor area or temporal region were taken and made into 1 to 2 cm long hair with intact follicle under 3 fold magnifier.The recipient area was punched with 21G or 22G syringe needle.Then the hair shaft was clamped with mi croforceps and the follicles were transplanted to the defective area.Results Folliculitis were found in two burn patients after the transplantation and cured by alcohol inunction.Hairs of the rest patients transplanted grew well.The direction and appearance were satisfied.The survival rate of hair was more than 90 ％.Conclusions It is feasible to restore the partial eyebrow defect by intact follicular transplantation by punching with syringe needle and clamping the hair shaft with microforceps.