Objective:To study the teaching effect of the teaching model of the teachers standardized patient (TSP) in clinical anesthesia teaching.Methods:Sixty students majoring in anesthesiology specialized in Shengjing Hospital of China Medical University were randomly divided into control group ( n=30) and observation group ( n=30). The teaching mode of TSP was adopted in the observation group, and the traditional teaching mode was applied in the control group. The differences of theoretical knowledge and clinical practice ability between the two groups were compared, and the satisfaction of the students was investigated by questionnaire. Data were analyzed by t-test and chi-square test using SPSS 20.0 software. Results:The clinical practice ability and clinical case analysis of the observation group were significantly better than those of the control group ( P<0.05), while there was no significant difference in the scores of theoretical knowledge between the two groups ( P>0.05). The questionnaire survey showed that the teaching mode of TSP had advantages in stimulating interest in learning, improving the ability of data collection, plan formulation, communication and emergency response, and enhancing their confidence in anesthesia and team cooperation ( P<0.05), while there was no significant difference in teaching satisfaction ( P>0.05). Conclusion:TSP teaching mode can ameliorate the clinical teaching effect of anesthesiology, especially in improving clinical practice ability.