1.Research progress of DNA methylation in the diagnosis of early colorectal cancer
Di CAO ; Guozhi YU ; Chuncheng REN ; Min WANG ; Kai WANG ; Yue SU ; Bin HUANG ; Xu HAN ; Wenhao MAN ; Yuru ZHANG
International Journal of Surgery 2022;49(5):351-355
Colorectal cancer is a common tumor of the digestive system with a high degree of malignancy. Most patients are in the advanced stages of the disease when they develop symptoms. Although the detection rate of traditional screening methods is improving with advances in imaging and the popularity of colonoscopy, the diagnosis of early, asymptomatic colon cancer is still unsatisfactory. Therefore, it is particularly important to further study the occurrence and development mechanism of colorectal cancer and obtain new ideas for the diagnosis and treatment.? In recent years, with the deepening of epigenetics research, the role of DNA methylation in the pathogenesis of colorectal cancer has gradually attracted attention. This paper will review the research progress of DNA methylation in colorectal cancer′s diagnosis and treatment.
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