OBJECTIVE: To investigate the roles of E-cadherin and beta-catenin play in the carcinogenesis and progression of laryngeal carcinoma. METHOD: Immunohistochemistry staining (PicTure two steps method) was used to detect E-cadherin and beta-catenin proteins expression in laryngeal carcinomas and normal epithelia around tumors. RESULT: In 60 laryngeal carcinomas, the abnormal expression rates of E-cadherin and beta-catenin were 55.00% and 66.67% respectively. The significant relationship was observed between abnormal E-cadherin and beta-catenin expression and differentiation, clinical stage and lymph node metastasis. There was a positive relationship between the expression of beta-catenin and E-cadherin in same sample. CONCLUSION The abnormal expression of E-cadherin and beta-catenin were closely related with differentiation, clinical stage, metastasis in laryngeal carcinoma.
Adult ; Aged ; Cadherins ; metabolism ; Carcinoma, Squamous Cell ; metabolism ; pathology ; Female ; Humans ; Laryngeal Neoplasms ; metabolism ; pathology ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Staging ; beta Catenin ; metabolism