Objectiveto investigate the effect of the scientific research projects established within the Hospital on mobilizing the enthusiasm of the medical staff of the Hospital,improving their scientific research quality,and promoting the scientific research development of the Hospital.Methods through analyzing the devotion to the projects within the Hospital and establishment of projects out of the hospital in recent 8 years,as well as output of scientific research achievements and paper publication.ResultsThe scientific research output is increased significant than the previous years,activities of the researchers were encouraged,financial fund is increased somewhat,and the level of research achievements and paper publication are increasing gradually year by year.ConclusionsThe scientific research projects established within Hospital play a promotion role for the development of scientific research of the Hospital.

Objective To evaluate the clinical therapeutic effect with microspheres embolization for giant hepatocellular carcinoma(HCC). Methods A prospective study was performed for 156 HCC patients needed for TACE, then randomly signed them into group M (embolized by microspheres alone), group L (embolized by lipiodol alone) and group M + L (embolized by microspheres combined with lipiodol). TACE of group M was performed by 300-700 μm microspheres. Group L selected lipiodol alone to embolize. While group M + L were embolized by about 1/3-1/2 lipiodol of total embolized volume and then microspheres feeding individual tumor vessels. Stoped the procedure when caused terminal vessel blockade. Before and after therapy, patients'liver function, serum α-fetoprotein level (AFP), responses of tumor, complications related to embolization and survive rates of 180 days and 360 days were analyzed among three groups.Enumeration data such as survive rates and positive response were compared by χ2 test, while measurement data were analyzed by one-way classification. Results The positive response (CR + PR) of group M was 38.5% (20/52)and (CR + PR + SD)73. 1% (38/52). Survive rates of 180 days and 360 days were 88. 5% (46/52) and 82. 3% (43/52). While those of group L were 42. 3% (22/52) ,76.9% (40/52),86.5%(45/52), 75.0% (39/52) and group M + L were 55. 8 % (29/52), 88.5 % (46/52), 94. 2% (49/52),86. 5％ (45/52). Significant difference of survival rates and total effective between group M + L and M,M + L and L was found(χ2 = 6. 27,6. 16, P ＜ 0. 05). At the same time adverse responses of incidence and persis time such as febricity, nausea and vomit, hepatic pain were more lower in group M + L and group M.Three groups febricity rate were 63.4% (33/52), 86. 5% (45/52) and 69. 2% (36/52), nausea and vomit were 67.3 % (35/52) ,84. 6% (44/52) and 76. 9% (40/52), hepatic pain were 59. 6% (31/52), 86. 5 %(45/52), 73. 1% (38/52) (χ2 = 6.55, 6. 22, 6. 90, P ＜ 0. 05). Conclusion Embolization with microspheres can get longer and more effective treatment. TACE with microspheres and lipiodol for embolizing HCC was more effective than with Microspheres or lipiodol alone.

This study was aimed to compare the difference of treatment on acute adjuvant arthritis (AA) by using dif-ferent energy densities withirradiation on ST36-Zusanli under the fixed wavelength (650 nm) by the semiconductor. Biological effect and traits of the laser irradiation were also studied. A total of 60 healthy male SD rats were random-ly divided into the normal control group, model group, low energy density group (61.89 J/cm2)and high energy density group (247.57 J/cm2). The Freund's complete adjuvant (FCA) was intradermallyinjected into rats' right hind paw to establish AA rat model. The treatment group was treated with 650nm semiconductor laser irradiation on ST36-Zu-sanli with the energy density of 61.89 J/cm2 and 247.57 J/cm2, respectively. The joint swelling degree, pain thresh-old, TNF-α and IL-1β level changes were observed on thefirst, third and fifthtreatment after modeling. The results showed that compared with the normal group, the joint swelling degree, pain threshold, TNF-α, and IL-1β were obvi-ously increased in the model group (P<0.05). After five times treatment, the semiconductor laser with low and high energy density had effect on acute inflammation. And the high energy density treatment effect had a better effect than the low energy density one (P<0.05). It was concluded that the energy density of 61.89 J/cm2 and 247.57 J/cm2 of semiconductor laser irradiation on ST36-Zusanli can relieve acute inflammatory pain and swelling caused by AA; re-duce the TNF-α and IL-1β concentration levels. Semiconductor laser irradiation had the characteristics of stimula-tion or inhibition, cumulative effect and parabola. Low energy density group obtained the best effect between the third and fifth treatment.

A number of institutional repositories were selected from Open DOAR and their website accessibility, linking time, linking effect and pressure were tested with evaluation tools.The accessibility of institutional repositories in China and its major problems were analyzed with certain suggestions proposed for improving their accessibility.

ObjectiveTo explore the effect of single glucocorticoid treatment and glucocorticoid joint cyclophosphamide treatment on thyroid-associated ophthalmopathy.MethodsRetrospective analysis of clinical data of 35patients used single glucocorticoid( single medicine group) and 16 patients used glucocorticoids joint cyclophosphamide(joint group) was carried out.ResultsThe effective rate of joint group(93.8％ ) was significantly higher than single drug group (68.6％) ( x2 =3.87,P ＜ 0.05).Simple using glucocorticoid had significant treatment effect at CAS score,prominent eyes degrees,soft tissue inflammation score,but the curative effect was significantly lower than the joint group ( P ＜ 0.05 ).The adverse reaction rate had no significant difference between two groups.ConclusionCompared to single glucocorticoid treatment,the glucocorticoid joint cyclophosphamide treatment had better effect and lower adverse reaction rate,especially suitable for patients who had no effect or low effect on hormone therapy.

BACKGROUND:Currently, inhaled glucocorticoid is still the classic treatment for asthma. Adult stem cell transplantation has made significant progress in a variety of diseases, and it also provides new insights into the treatment of asthma.OBJECTIVE:To summarize the recent advances in the treatment of asthma with adipose-derived stem cells and related adult stem cells, and to discuss the therapeutic safety of adipose-derived stem cells and possible research directions in asthma therapy.METHODS:Relevant articles published from 2001 to 2016 were searched in PubMed, CBM, CNKI, and Wanfang databases. The keywords were (adipose-derived stem cells[All Fields]) OR (adipose stem cells[All Fields]) OR (adipose-derived mesenchymal stem cells[All Fields]) AND (asthma[All Fields]) in English and Chinese, respectively.RESULTS AND CONCLUSION:A total of 125 literatures were initially searched, and finally 54 representative papers were selected. Adipose-derived stem cells may reduce airway inflammation, airway hyperresponsiveness, ease collagen deposition and scar tissue formation, promote neovascularization, and reconstruct damaged airways in the mouse asthma model through immune regulation. It is necessary to understand its treatment mechanism of action deeply and comprehensively and carry out genomic analysis before introduction of adipose-derived stem cells as a conventional clinical treatment. In summary, adipose-derived stem cells may be a therapeutic potential for the treatment of airway allergic inflammatory diseases such as asthma.

Objective To explore the theory and measures of armymen's clinical flow through information technology based on an exclusive armymen clinical area.Methods On the basis of No.1 Military Medical Project,such system was developed as automatic medical service classification & guide system,clinic backstage & auto-medicine provision system and comprehensive clinical service system in order to optimize medical service for armymen.Results By integrating the armymen's clinical information system,Navy General Hospital optimized comprehensively the clinical flow of registration,waiting,diagnosis,pricing,medicine pick-up,etc.Therefore,the efficiency of medical service for the army was greatly improved.Conlusion The full application of information technology will make an improvement in clinical flow and provide better service to army patients.

Objective:To study the efficacy of social skill-training on the positive symptoms, negative symptoms and cognitive function of patients with chronic schizophrenia.Method:100 subjects who met with the criteria of Chinese Classification and Diagnostic Criteria of Schizophrenia were randomly assigned to the skill-training group (50 patients) and the control group (50 patients). Under the condition of stable antipsychotic medication, the skill-training group received the skill-training course offered by Liberman RP for 12 weeks. BPRS and SANS were used to evaluate every four weeks; WCST and SDSI were evaluated before and after the treatment.Result:(1) 45 patients of skill-training group and 46 patients of control group completed the study. (2) There were significant differences between skill-training group and control group in total score, anxiety depression and lacking active factor of BPRS (P

Objective To estabolish a scientific, objective, comprehensive and quantitative combined with qualitative evaluation indicator system for research input-output effeciency, which is applied especially for grade 3 and firt-class hospital in Xinjiang Uygur aotunomous region.Methods We analyzed the research input-output effeciency of one hospital.We performed three time questionaires to 25 experts who come from different fields, by using Delphi method and analytic hierarchy process.Based on screening estimation of experts, we determined the indicators, the weight and the standards of each indicator, the logic consistency of the above were tested, and the model of input-output ratio was set up.Results The response rate of three-time quesitonaires was above 85％.Authority coefficient of estimation indicators from experts was above 0.7.The kandall coefficient of concordace was between 0.179 and 0.442, P＜0.01.We estabolished evaluation indicator system for research input-output effeciency composed of 5 grade Ⅰ indicators, 12 grade Ⅱ indicators and 28 grade Ⅲ indicators.Conclusions This study result is reliable, the index system conform to the industry standard and regional characteristics.In order to improve the hospital performance level, increaseing investment in scientific research should be needed.Combined with scientific research input-output, the management should take measures to optimize the allocation of resources, broaden the way of project application fighting for money, pay attention to personnel training amd form a scientific research team.

Objective To observe the clinical effect of manipulation combined with McKenzie technique on discogenic low back pain. Methods 80 patients were randomly divided into control group (n=39, 1 case was lost) and observation group (n=40). The patients in obser-vation group received manipulation and McKenzie technique, while the control group received manipulation only. All the patients were eval-uated with Oswestry Disability Index (ODI), Visual Analogous Scale (VAS) and Self-rating Depression Scale (SDS) before and 3 weeks af-ter treatment. Results The scores of ODI, VAS and SDS decreased after treatment in both groups (P<0.01). The score of ODI and VAS were lower in the observation group than in the control group (P<0.05), while there was no significant difference in the score of SDS between two groups after treatment (P>0.05). Conclusion Manipulation combined with McKenzie technique is more effective on discogenic low back pain.