Purpose　To assess the clinical efficacy and safety of acute cerebral progressive infarction cured with urokinase in combination with heparin sodium. Methods　There were 50 cases in the control group and treated group. The treated group was treated with urokinase 300,000 units/day intravenous for 1～2 days, heparin sodium 12,500 units/day intravenous for 5 days, the control group was treated with heparin sodium 12,500 units/day intravenous for 5 days. All patients were treated within 5 days of onset and the deterioration of neurological deficits within 10 hours. The hypodensity was showed by brain CT scan without hemorrhage, MDS score was given before and after cure 30 days for comparison. Results　The neurological deficits improvement in the treated group was more efficient than the control group and no hemorrhage was found. Conclusion　Middle dose urokinase infusion in combination with heparin sodium intravenous in treatment of acute cerebral progressive infarction was safe and effective and showed obviously clinical valuable.

Objective:To investigate the Philips 256-slice CT coronary angiography images on a variety of forms of coronary artery calcification and coronary stenosis in relation to predict the value of the study of acute coronary events by coronary angiography and coronary artery calcification score.Methods: From May 2014 to February 2015 in the Third Affiliated Hospital of Qiqihar in patients with suspected coronary artery disease, with256-slice spiral CT coronary artery enhancement scanning and DSA, and using software of automatic analysis for coronary artery calcium score analysis, and comparing the accuracy of the two methods of inspection, combined with the clinical data of patients with scientific prediction of acute coronary events.Results: Different forms of coronary artery calcified plaque resulting in local differences in the proportion of luminal stenosis were statistically significant. AS calcium score standard are in grouped in patients with coronary heart disease (CHD),along with increasing calcium score,the risk of coronary heart disease also increase.Conclusion: The diagnosis of coronary artery calcification score of coronary heart disease have a higher value. Calcium score for judging coronary artery stenosis to have high specific degrees, worthy of clinical popularization and application.

To simultaneously determine the contents and explore the pharmacokinetics of ferulic acid and paeoniflorin by high performance liquid chromatography (HPLC) after oral administration of Modified Xiao-yao Decoction (MXYD), a compound of traditional Chinese herbal medicine.

Objective To explore the effect of atorvastatin on postoperative complications after the burr hole drainage of chronic subdural hematoma (CSDH). Methods The clinical data of 172 CSDH patients who had underwent the burr hole drainage were retrospectively analyzed. Among them 82 patients were given atorvastatin (atorvastatin group), and 90 patients were not given atorvastatin (control group). The postoperative complications were compared between 2 groups. Results All patients were followed up for 6 months. The total incidence of postoperative complications in control group was significantly higher than that in atorvastatin group:47.78%(43/90) vs. 31.71%(26/82), and the recurrent rate of subdural hematoma and incidence of subdural effusion in control group were significantly higher than those in atorvastatin group: 22.22% (20/90) vs. 8.54% (7/82) and 28.89% (26/90) vs. 12.20%(10/82). There were statistical differences (P<0.05). There were no statistical difference in the incidences of pneumocephalus, acute epidural/subdural hematoma and brain damage induced by drainage tube (P>0.05). Conclusions Atorvastatin can improve the prognosis of CSDH patients, especially in reducing the incidence of recurrent subdural hematoms and subdural effusion.

There is a fact that there is TCM education in some western medical universities.Starting from the problems existing in medical universities,the author in this article thinks TCM education should bring into full play its superiority and put emphasis on training talented persons with knowledge of TCM and western medicine and talented persons with ability to communicate with foreigners in TCM,and so on.It's the developing trend for TCM education development in some western medical universities and it's also the problem needing to be highly thought of in the reform of TCM education in western medical universities.

Objective: To examine the causal relationship between inflammatory factors and breast cancer using two-sample Mendelian randomization (MR) approach, so as to provide the basis for the prevention and treatment of breast cancer. Methods: Data of 91 inflammatory cytokines (n=14 824) and 5 subtypes of breast cancer (n=247 173) were collected from genome-wide association studies (GWAS). Single nucleotide polymorphism (SNP) associated with 91 inflammatory factors were selected as instrumental variables. MR analyses were performed using the inverse-variance weighted (IVW) method with inflammatory factors as exposure factors and breast cancer as outcome variables. The risk of type I error and the effect of multiple testing were reduced using the FDR correction method. The stability and reliability of the results were verified using Steiger test of directionality, MR-Egger regression, MR-PRESSO test and leave-one out method. Results: Twenty-three inflammatory factors, including β nerve growth factor, interleukin-5, cystatin D and C-X-C chemokine ligand 1 were statistically associated with breast cancer (all P<0.05). After FDR adjustment, only evaluated abundance of oncostatin-M was found to be statistically associated with an increased risk of Basal-like (triple-negative) breast cancer (OR=1.186, 95%CI: 1.081-1.302, P=0.001, q=0.029), and the other 22 inflammatory factors had a high risk of type I error (all q>0.1). The sensitivity analysis indicated that the results were robust. No instrumental variables were found to have a significant impact on the results, which could exclude the influence of heterogeneity, horizontal pleiotropy, and reverse causality on the outcome. Conclusion The increased abundance of oncostatin-M may increase the risk of Basal-like (triple-negative) breast cancer.

To investigate the nature of syndrome of traditional Chinese medicine by means of pharmacokinetic (PK) method.

Objective:To investigate the effects of establishment of a trauma center on the therapeutic efficacy for patients with severe multiple injuries.Methods:A retrospective study was conducted in the patients who had been treated at The Second Affiliated Hospital, University of South China for severe multiple injuries from October 2015 to September 2019. They were assigned into 2 groups. The study group included 102 patients who had been treated after establishment of our trauma center (from October 2017 to September 2019) while the control group 126 patients who had been treated before establishment of our trauma center (from October 2015 to September 2017). The 2 groups were compared in terms of time for emergency treatment (from admission to emergency surgery or ICU), ICU stay, hospital stay, total medical costs and mortality.Results:There was a significant difference between the 2 groups in time for emergency treatment [51 (47, 57) min for the study group versus 97 (87, 107) min for the control group] ( P<0.05). There were no significant differences between the 2 groups in ICU stay [4 (1.8, 9.3) d versus 4 (2.0, 10.0) d], hospital stay [25.5 (15.8, 39.0) d versus 21.5 (12.8, 41.5) d], or total medical costs [￥41,259.0 yuan (￥26,950 yuan, ￥81,599 yuan)] ( P>0.05). There was a significant difference between the 2 groups in mortality [12.7% (13/102) for the study group versus 24.6% (31/126) for the control group] ( P<0.05). Conclusion:Establishment of a trauma center can effectively shorten time for emergency treatment, improve treatment efficacy and reduce mortality for patients with severe multiple injuries.

OBJECTIVE: To evaluate the safety and efficacy of Yiqi Pingchuan Granule in treating acute attack of asthma due to qi deficiency and cold syndrome. METHODS: A randomized controlled trial was conducted. A total of 80 patients with an acute attack of asthma were included. They were allocated into two groups randomly in a ratio of three to one. Sixty patients in the treatment group received Yiqi Pingchuan Granule and 20 patients in the control group received Ruyi Dingchuan Pill. Patients in both groups were treated for 7 days. RESULTS: There were no significant differences in traditional Chinese medicine syndrome, clinical symptoms and lung function between the two groups (P>0.05). After treatment, the forced expiratory volume in 1 second was increased in the treatment group (P<0.05), and the peak expiratory flow was accelerated in the control group (P<0.05). No significant side effects were noted in both groups. CONCLUSION: Yiqi Pingchuan Granule is safe and effective in treating acute attack of asthma due to qi deficiency and cold syndrome.

Objective:To explore the changes of personality in medical college freshmen from 2010 to 2019 and the difference of gender.Methods:The cross-temporal meta-analysis and independent sample t-test were used to explore the change of medical college freshmen’s scores on 16 personality factor questionnaire (16PF) in the past 10 years (2010~2019) and the gender difference.A total of 17 395 samples of medical college freshmen were enrolled in the present study. Results:(1)The score of Warmth(A), Reasoning (B), Emotional Stability(C), Dominance(E), Liveliness(F), Rule-Consciousness(G), Social Boldness(H) and Perfectionism (Q3) were negatively correlated with year ( β=-0.93, -0.64, -0.85, -0.48, -0.80, -0.65, -0.92, -0.91, all P<0.01), while Sensitivity(I), Vigilance(L), Abstractness (M), Privateness (N), Apprehension (O), Openness to change (Q1), Self-Reliance (Q2), and Tension (Q4) were positively correlated with years ( β=0.72, 0.88, 0.81, 0.65, 0.86, 0.95, 0.90, 0.88, all P<0.01). (2)The scores in female freshman were higher than those in male freshman in Warmth, Sensitivity, Abstractness, Privateness, Apprehension, and Tension ( t=22.51, 18.15, 21.15, 5.89, 12.35, 5.46, all P<0.01), while the scores in female freshman were lower than those in male freshman in emotional stability, dominance, rule-consciousness, social boldness, and vigilance ( t=-18.25, -16.54, -9.75, -5.05, -9.97; all P<0.01). Conclusion:The warmth, reasoning, emotional stability, dominance, liveliness, rule-consciousness, social boldness and perfectionism present a decreasing tendency, while sensitivity, vigilance, abstractness, privateness, apprehension, openness to change, self-reliance, and tension present a rising tendency. The change tendency in both male and female are consistent with the overall trends and the significant gender differences are found in some personality traits.