Objective To investigate the relationship among electrocardiogram QRS complex duration,left ventricular ejection fraction( LVEF),N-terminal pro-brain natriuretic peptide( NT-proBNP)and their relation to New York Heart Association (NYHA)functional classification in patients with chronic heart failure(CHF),and observe the intervention effects of Shenfu injection(SFI)on patients with CHF. Methods A total of 72 CHF patients were randomly assigned to treatment group(36 cases)and control group(36 cases). Patients in the control group received standard care,and those in the treatment group received standard care plus 1. 0 mL·kg-1 ·d-1 of SFI in 5% glucose for two weeks. Before and after the treatments,the electrocardiogram QRS complex duration,LVEF,NT-proBNP were measured and NYHA functional classification was evaluated. Results Electrocardiogram QRS complex duration was negatively correlated with LVEF and was positively correlated with NT-proBNP and NYHA functional classification( P〈0. 05 ). After the treatment,the proportion of patients with NYHA classⅠ-Ⅱsignificantly increased and classⅢ-Ⅳsignificantly decreased in both groups. The treatment group was superior to the control group in reinstating cardiac function( P〈0. 05 ). After the treatment,electrocardiogram QRS complex duration and the levels of NT-proBNP were significantly descended and LVEF were significantly ascended in both groups(P〈0. 05). The level of NT-proBNP in the treatment group was significantly lower than in the control group(P〈0. 05),but electrocardiogram QRS complex duration and LVEF did not show significant difference. The prior-and post-treatment difference in electrocardiogram QRS complex duration and LVEF was more obvious in the treatment group than in the control(P〈0. 05). Conclusion The extension of electrocardiogram QRS complex duration is correlated with plasma NT-proBNP elevation and cardiac dysfunction,which can be used as a reference for disease progression or medication efficacy. SFI is effective on CHF of the yang-qi deficiency type.

Objective To observe the anti-atherosclerosis effects of Guizhi Fuling Capsule. Methods 50 healthy SD male rats were randomly divided into 2 groups: normal group (n=12) and AS model group(n=38). The model of experimental AS rats was established by feeding high cholesterol diet and intraperitoneal injecting VitD3. The normal control group was fed by ordinary diet. AS model group was further divided into 3 groups randomly: AS group(n=12), control group (n= 12), and therapy group(n= 12). The therapy group was given Guizhi Fuling Capsule by intragastric administration.The control group was given simvastatin and captopril by intragastric administration. 0.9% NaCl was given to the AS group instead of Guizhi Fuling Capsule. The rats were killed at the 16th weekend, and their aorta arch and breast aorta were observed.Blood fat and serum levels of Endothelin-1 (ET-1), Nitric oxide (NO), high-sensitivity C-reactive protein (hs-CRP) were detected respectively. Immunohistochemistry technology was used for observing the expression of intercellular adhesion molecule- 1 (ICAM- 1 ) in breast aorta. Results The values of ET- 1, NO, hs-CRP and the amount of ICAM- 1 were (142.61 ±25.67)ng/ml, (66.05 ± 8.63) μmol/L, (2.86±0.40)mg/L, (0.29±0.05) in the normal group; (182.38±22.96)ng/ml, (28.70±4.49)μmol/L, (5.60±0.49)mg/L, (0.58±0.06)in the AS group; (154.37±21.11)ng/ml, (45.88±11.36)μmol/L, (3.66±0.34)mg/L, (0.37±0.04)in the control group and (152.13±23.23)ng/ml, (57.67±8.96)μmol/L, (3.70±0.40)mg/L, (0.36±0.04) in the therapy group respectively. The levels of ET-1, NO, hs-CRP and the amount of ICAM-1 have significant difference between the AS group and the normal group(P=2.47E-4, 6.02E-19, 1.11E-12, 2.51E-18). There was also significant difference between the control group and the AS group(P=0.005, 1.59E-14, 1.87E-5, 3.87E-14). The level of NO in the therapy group was higher than that in the control group (P=0.002). The levels of ET-1, hs-CRP and the amount of ICAM-1 did not have significant difference between the therapy group and the control group(P=0.81, 0.81, 0.48) Conclusion Guizhi Fuling Capsule has effects of Anti-atherosclerosis on rats with AS.

Objective To evaluate the effects of continuous nursing on the therapy of type 2 diabetics retinopathy. Methods A total of 100 DR patients hospitalized in our hospital from June 2015 to January 2016 were enrolled, and they were randomly divided into 2 groups:50 in the intervention group, and the other 50 as controls. The control group received routine nursing, while the intervention group received continuous nursing on the basis of routine nursing. Two groups were both provided nursing satisfaction questionnaire and the Summary of Diabetes Self-Care Activitiesby a certain personnel. Relative evaluation indices were collected at the time when the patients were discharged and 1 year, 2years after that. The differences of nursing satisfaction, self-management ability, fasting blood glucose, blood glucose 2 hours after meal, visual acuity and readmission rate between two groups were compared with statistical methods. Results The fasting blood glucose, postprandial 2 hour blood glucoseafter one and two years were (5.71 ± 0.64), (9.42 ± 0.86), (5.89 ± 0.64) and (9.58 ± 0.80)mmol/L, respectively. The results ofthe control group were (6.81 ± 0.95), (11.32 ± 1.50), (7.24 ± 0.81) and (12.63 ± 2.17)mmol/L, respectively, and there were significant difference between 2 groups (t =-9.306--6.814, all P<0.05). The score of Summary of Diabetes Self-Care Activities score of the intervention group at the end of the follow-up period was 53.74 ± 7.82, while that in the control group was 42.02 ± 5.07, and the difference between the 2 groups was statistically significant (t = 8.883, P< 0.05).The rate of visual acuity, visual acuity after 1 and 2 years and nursing satisfaction were 2％ (1/50), 6％ (3/50) and 100％ (50/50) in the intervention group,and those in the control group were 18％ (9/50), 32％ (16/50), 78％ (39/50), with a significant difference between 2 groups (Z =-2.653,-3.297,-5.541, P<0.05). The readmission rate patients in the intervention group was 2％(1/50), while the control group was 28％(14/50), and there was significant difference between 2 groups (χ2=13.43, P<0.05). Conclusions When continuous nursing care was applied to type 2 diabetic retinopathy, the subjective initiative of patients and their family would be mobilized, and the patients′self-management ability would be improved, thus helped to control blood glucose andvisual acuity, and consequently promotes the prognosis while delays the progress of diabetic retinopathy, reduces the incidence of blinding due to DR, decreases the rate of readmission, reduces the economic burden of patients, improves patients′satisfaction.Continuous nursing care has great application value in medicine.