Many PICU and NICU have been gradually established from 80's in China,and the rescueing success rate of critically ill pediatrics is increasing fast.However,to assess the severity of disease and to determine the ICU admission standards is a quite complex job.Using scoring systems to predict hospital mortality in critically ill patients can be more objectively,scientifically and effectively.There are some scoring systems widely used in the world.Hospitals in china use PCIS more and these in foreign prone to PRISM score highly in pediattic field.PCIS was made in china and it achieves great success on the side of risk adjustment and mortality prediction.But pediatrics are special,sometimes the severity of disease is not completely consistent with the prognosis and the differences among individuals cannot be ignored yet,so PCIS have unavoidable limitations.The scoring systems and clinical symptoms and signs and therapeutic effect should be combined to assess the severity of disease more accurately.Acute physiology and chronic health evaluation(APACHE),and sequential organ failure estimation score(SOFA) are rarely used in the field of pediatric applications,but both are useful tools for clinical research,if it can be introduced into the pediatric field,there may be a new breakthrough.Besides,Pediatric Risk of Mortality Score and Pediatric Risk of Mortality are not widely used in our country.

0.05).Among the test group.the number of medium nebulization were significatly more than that in the contrast group(P0.05).Conclusions: Early continuous and administration of oxygen nebulization with 0.45%sodium chloridecan not only decrease the Visco-elasticity of sputum, but aslo sustain the stability of oxygen partial pressure in blood in the study.

The article expounds the advantages and existing problems of TCM differentiation by signs,puts forwards the concept of “sign factor”,including sign factors of disease location and disease nature;the contents of the new system are as well provided,finally it points out the great meaning of the said system to the development of TCM.

Objective To investigate the brain protection effect of cinnamon water extract on chronic cerebral ischemia rats. Methods We selected male Wistar rats to make chronic cerebral ischemia model by bilateral carotid artery ligation permanently,and the models were randomized into a model group,cinnamon high or low dose group,with 20 in each group. A control group with 20 rats was treated with sham operation. The cinnamon high and low dose groups were given cinnamon water extract 4.2g/kg and 2.1g/kg respectively by gavage in succession for 4 weeks. Y-maze test was used to test the cognitive ability of the rats. The superoxide dismutase (SOD) activity,malondialdehyde (MDA) content,and the expressions of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) were determined. Results Compared with the sham-operated group,the cognitive ability of the model group declined,the SOD activity of brain tissues decreased,and the MDA content increased. Cinnamon improved the SOD activity,reduced the MDA content,increased the NGF and BDNF expressions,and the effect of high-dose group was better than that of the low-dose group. Conclusion Cinnamon plays its role in cerebral protection through increasing the SOD activity and expression of NGF and BDNF and reducing content of MDA.

In this paper,the structural analysis of a case of Hb TaiBei ?22(B4)Glu-Gly found in the Naxi nationality in Yunnan Province was described.This is the first case of Hb variant found in this nationality.

This paper reports a reseach of abnormal Hb for Naxi Moosus minorities nationalities in Lijiang District yunnan,The number of total research is 2230,The ratio of detection is 0.81%, and studied.The variant type of abnormal Hb.These result are Hb E,G-Taibei,US (unstable)respectically,and a case of homozygote of fetal hemoglobin which is found and re- ported in Chima for the first time.

The resuets of the screening of abnormal Hb among people of Hani and Yi minority nationalitios in Honghe, Yunnan were reported in this paper, It was found that the inci- dence of abnormal Hb in This area was 1.25%, By studying the types of abnormal Hb, we found that the main abnormal Hb in Hani and Yi minority nationalities was Hb E. In addi- tion, a slow-mouing Hb was found, Primary structural analysis showed that it was a ?-Chaim variant designated as Hb G-Yuanyang (?43 (CD2) Glu-Gly),. it is a new vari- ant type of abnormal Hb found and reported for the first time in Yunnan, China.

Objective To compare the effects of mammaplasty, non mammaplasty and prosthesis reconstruction in the treatment of quadrant or massive mastectomy. Methods One hundred and twenty patients with segmental or quadrant mastectomy in the First People′s Hospital of Huizhou from February 2015 to December 2016 were selected for the study. The patients were divided into three groups:the mammaplasty group (48 cases),the non mammaplasty group (40 cases),and the prosthesis reconstruction group (32 cases). The patients in the mammaplasty group were treated with quadrant or massive mastectomy, patients in the non mammaplasty group were treated with chest wall fat fascia flap and the prosthesis reconstruction group was treated with the application of the skin flap of the lateral chest wall. The general operation situation of the three groups were recorded,including operation time,indwelling time of drainage tube,hospitalization time and postoperative hospitalization time. The satisfaction and complications of breast reconstruction were compared among the three groups. Results The operation time of the mammaplasty group, non mammaplasty group and prosthesis reconstruction group were (71. 5±18. 4) min,(55. 9±14. 3) min and (89. 7±21. 3) min respectively,there was significant difference among the three groups (F=31.32,P<0.01).The operation time of the mammaplasty group was longer than that of the non mammaplasty group, but less than that of the prosthetic reconstruction group, the difference was statistically significant ( P< 0. 05 ) . The hospitalization time and postoperative hospitalization time in the prosthesis reconstruction group were ( 13. 7 ± 3. 4 ) d and ( 10. 9 ± 2. 6 ) d, mammaplasty group (11. 4±2. 2) d and (8. 6±1. 9) d respectively,non mammaplasty group (11. 3±2) d and (8±1. 8) d respectively. The differences among the 3 groups were statistically significant (F=10. 20,18. 88,P <0. 01) . The postoperative hospitalization time of the prosthesis group was significantly longer than those in the other two groups ( P<0. 05) . The indwelling time of the drainage tube was close in the 3 groups. The overall satisfaction of breast reconstruction in the mammaplasty group, non mammaplasty group and the prosthesis reconstruction group were respectively ( 9. 2 ± 0. 8 ) points, ( 9. 1 ± 0. 6 ) points, ( 7. 9 ± 1. 3 ) points, and the difference was statistically significant ( F=23. 22,P<0. 01) . The satisfaction degrees of breast reconstruction in the mammaplasty group and the prosthesis reconstruction group were equal, higher than that in the non mammaplasty group,the differences were statistically significant ( P<0. 05) . The incidence of wound infection in the mammaplasty group, non mammaplasty group and prosthesis reconstruction group were 10. 4% ( 5/48 ) , 10. 0% (4/40) and 6. 3% (2/32),respectively,the difference was not statistically significant (χ2=1. 29,P=0. 08) . Conclusion In quadrant or massive mastectomy,lateral chest wall fat fascia flap has simple operation and high safety,and the restoration effect is good,which can be widely used in clinical practice.

Focal adhesion kinase (FAK), a type of protein tyrosine kinase in the cytoplasm, is highly expressed in many types of malignant tumors. FAK is named as such because of its close relationship with the cell adhesion function. Recent studies show that FAK is expressed in many tumor cells and has a definite relationship with cancer progress, metastasis, and prognosis. Accordingly, FAK has become one of the new tumor therapeutic targets that will bring new methods for tumor therapy.

Objective To evaluate the effect of community nurse training in peripherally inserted central catheter (PICC) on community nursing quality of tumour patients with indwelled PICC during the intermission of chemotherapy.Methods A prospective study was performed with a total of 220 patients with esophageal or lung cancer enrolled from September 2011 to March 2013 in the Department of Cardiothoracic Surgery,the First Affiliated Hospital of Chongqing Medical University.The 220 patients included 174 males (79.1％) and 46 females (20.9％),at the age of (61.1 ±9.0) years.With the start of community nurse training as the cut-off line,the patients were divided into pre-training group (n =119) and post-training group (n =101).PICC-related complications and patient satisfaction were compared between the 2 groups.Results The overall PICC-related complication rate was 20.9％ (46/220) during community nursing,including,in the order of declining incidence,infection (7.2％,16/220),and venous thrombosis (4.5％,10/220),catheter occlusion (3.6％,8/220),catheter dropping (2.7％,6/220),and leaking/damage (2.7％,6/220).The total complication rate and incidence of infection in the post-training group were both significantly lower than those in the pre-training group (14.9％ vs.26.1％,P =0.047 ; 3.0％ vs.10.9％,P =0.035),and patient satisfaction (including satisfaction for answers to questions about PICC,feelings about PICC indwelling and PICC position,and overall satisfaction) was significantly higher than in the pre-training group (P =0.003,P =0.011,P =0.001).Conclusion Community nurse training programmes have positive effects on improving PICC-related nursing and patient satisfaction in cancer patients with PICC indwelling during intermissions of chemotherapy.