Objective To observe the effect of Sopfrology-Lamaze childbirth breathing training on the delivery quality and negative mood of pregnant women.Methods 218 pregnant women were sampled and randomly divided into study group(A group,n =122) and control group(B group,n =96).A group learned the method and technique of Sopfrology-Lamaze childbirth breathing.From 28th week pregnancy to delivery,the times of training was more than 3 per week,and lasted 20 minutes.The rate of cesarean delivery,rate of severe pain,the time of labor,the amount of bleeding after 2h labor,and the dosage of patient controlled analgesia were observed.The selfrating anxiety scale (SAS) and self-rating depression scale(SDS) were used to assess the mood of prengnat women in 28th week pregnancy,before and after labor.Results There were significant difference in rate of cesarean delivery(A group 7.4％,B group 17.7％,x2 =5.46,P ＜ 0.01),rate of severe pain (A group18.8％,B group 59.4％,x2 =37.9,P ＜ 0.05),amount of bleeding after 2h labor (A group (219.43-± 31.47) ml,B group (287.5 ± 37.83)ml,t =14.50,P ＜ 0.05),and the dosage of patient controlled analgesia (A group(13.25 ± 1.89)ml,B group (19.87 ±2.52)ml,t=21.43,P＜0.05) between A group and B group.The SAS and SDS scores were lower in A group (SAS:before labor(44.3 ±7.6),after labor(42.2 ±4.7) ;SDS:before labor(45.2 ±4.7),after labor(42.2 ± 5.1),P ＜ 0.05) than those in B group (SAS:before labor(48.5 ± 6.6),after labor(47.35 ±5.1) ; SDS:before labor(47.7 ± 5.3),after labor (46.6 ± 6.3),P ＜ 0.05).Conclusion Sopfrology-Lamaze childbirth breathing training can improve the delivery quality and negative moods of pregnant women

OBJECTIVE: To explore the characteristics and clinical application of alginate dressing to provide better biological dressing for clinical wound healing. METHODS: A computer-based online search of CNKI, Medline, Wanfang, Science Direct, and Ei databases was performed for related articles published between January 1960 and October 2009, with the key words "alginate, dressing, clinical application" in Chinese and English. Studies regarding characteristics and clinical application of alginate dressing were included. Repetitive and Meta analysis were excluded. In addition, related books were manually searched. RESULTS: A total of 65 articles were collected, 17 were included, and 48 repetitive or Meta analyses were excluded. Alginate is natural polysaccharide carbohydrate extracted from sea tangle, and alginate dressing is soft non-textile fiber refined from seaweed. It contains 85% natural alginate fiber and 15% sodium tvIose. It can absorb effusion, form gelate, and exchange Na~+/Ca~(2+) with effusion. Alginate dressing has been widely used in bedsore treatment, anal fistula nursing, stoma nursing, and diabetic foot nursing. Compared with traditional dressing, infection rate of alginate dressing is lower due to good impermeability, promotion of regional vessel proliferation and blood supply, as well as moist and slightly acidic environment which benefits neutrophil function enhances disinfection. Moreover, it can be used in wound healing following abdominal region operation and abscess incision drainage.CONCLUSION: Alginate dressing provides appropriate environment for wound growth, retains active materials in diffusion, promotes active material release, benefit necrotic tissue solution and cell proliferation and differentiation, as well as epithelial cell migration. Moreover, it maintains hypoxia state of wound, stimulates newly generated capillary growth, and promotes granulation tissue growth.

Aim To study the effect of two racemic ketamine, S(+)-ketamine and R(-)-ketamine on stimulus-induced superoxide generation and intracellular calcium in vitro. Methods The stimulus-induced superoxide generation in human neutrophils was determined by using method of cytochrome C reduction. The intracellular calcium in human neutrophils was measured by chemiluminescence with Fura-2 loading. The phosphorylation of p47phox of NADPH oxidase in neutrophils was detected by Western blotting. Results S(+)-Ket and R(-)-Ket inhibited fMLP-induced superoxide generation in neutrophils in a concentration-dependent manner. In the case of PMA, S(+)-Ket inhibited PMA-induced superoxide generation and elevation of intracellular calcium of neutrophils in a concentration-dependent manner, whereas R(-)-Ket slightly increased PMA-induced superoxide generation and elevation of intracellular calcium of neutrophils. On the other hand S(+)-Ket inhibited the phosphorytion of p47phox of NADPH oxidase subunit,which R(-)-Ket was increased. EGTA can abolished the inhibition of S(+)-Ket on PMA-induced phosphorytion of p47phox.Conclusion S(+)-Ket inhibits the phosphorylation of p47phox of NADPH oxidase subunit and the superoxide generation in human neutrophils via PKC-calcium signal pathway.

Fibroblast growth factor(FGF)-21 is a novel insulin-independent glucose regulator,and can be a potential therapeutics for treatment of type Ⅱ diabetes.Although FGF-21 was discovered recently,the insight into its biology and therapeutic utility is rapidly evolving.A number of key metabolically-linked molecules and pathways have been suggested to be involved in the mechanism of action of FGF-21,which enables us to renew the understanding of the FGF-21.The aim of this review is to report the update research outcomes.

OBJECTIVE:To explore the characteristics and clinical application of alginate dressing to provide better biological dressing for clinical wound healing.METHODS:A computer-based online search of CNKI,Medline,Wanfang,Science Direct,and Ei databases was performed for related articles published between January 1960 and October 2009,with the key words "alginate,dressing,clinical application"in Chinese and English.Studies regarding characteristics and clinical application of alginate dressing were included.Repetitive and Meta analysis were excluded.In addition,related books were manually searched.RESULTS:A total of 65 articles were collected,17 were included,and 48 repetitive or Meta analyses were excluded.Alginate is natural polysaccharide carbohydrate extracted from sea tangle,and alginate dressing is soft non-textile fiber refined from seaweed.It contains 85% natural alginate fiber and 15% sodium tvlose.It can absorb effusion,form gelate,and exchange Na+/Ca2+ with effusion.Alginate dressing has been widely used in bedsore treatment,anal fistula nursing,stoma nursing,and diabetic foot nursing.Compared with traditional dressing,infection rate of alginate dressing is lower due to good impermeability,promotion of regional vessel proliferation and blood supply,as well as moist and slightly acidic environment which benefits neutrophil function enhances disinfection.Moreover,it can be used in wound healing following abdominal region operation and abscess incision drainage.CONCLUSION:Alginate dressing provides appropriate environment for wound growth,retains active materials in diffusion,promotes active material release,benefit necrotic tissue solution and cell proliferation and differentiation,as well as epithelial cell migration.Moreover,it maintains hypoxia state of wound,stimulates newly generated capillary growth,and promotes granulation tissue growth.

[Objective] To compare the efficacy of Chinese traditional medicine,metformin and cyproterone on reducing insulin resistance,improve metabolic status of glucose and lipid and raise ovulation rate in women with polycysitic ovarian syndrome.[Methods] 100 women with PCOS were divided into three groups:40 patients chosen to be treated by Chinese traditional medicine.The rest were randomly divided into two groups which both contain 30 patients.One group is treated by metformin while another one is treated by cyproterone.Total 87 patients finished the treatment of three months.Basal body temperature(BBT),body mass index,total testosterone,fasting serum insulin and blood sugar levels as well as lipid spectrum were measured and compared among all the patients before and after treatment.[Results] No significant difference is found in the baseline characteristics among three groups before treatment.In Chinese traditional medicine group,90%(36/40)patients finished the treatment,and 33%(12/36)patients ovulated.In metformin group,86%(26/30)patients finished the treatment,and 19%(5/26)patients ovulated.In cyproterone group,83%(25/30)patients finished the treatment,and 16%(4/25)patients ovulated.Ovulation rate was significantly higher in Chinese traditional medicine group than those in metformin and cyproterone groups.There was significant difference between Chinese traditional medicine group and cyproterone group(P

Influenza viruses can infect humans, lead to epidemics within populations, and even cause global pandemics. During the non-pandemic period, there is a continuous threat as avian or swine influenza viruses cross the species barrier to infect humans, resulting in zoonotic influenza infections. For the purpose of pandemic preparation and control, it is crucial to strengthen surveillance, scientific research, and risk assessment of these zoonotic influenza viruses. Here, we focus on the latest zoonotic influenza viruses that have recently garnered significant attention, providing an overview of their latest epidemiological trends and research progress, thereby facilitating scientific risk assessment.

Objective To explore the effect of continuous nursing based on WeChat public platform on the patients with high risk of pressure ulcers. Methods Selecting 165 pairs of high-risk patients and their caregivers from the emergency department of pressure ulcers in the General Hospital of Chinese People′s Armed Police Forces, and they were divided into control group and experimental group by paired random method. There were 83 pairs in control group, and 82 pairs in experimental group. The control group gave oral education according to the traditional model, and adopted the way of telephone follow-up for continuous nursing. While the experimental group let patients and their family members follow the Wechat public account that specially developed on Wechat platform and get continuous nursing in new models to come true networking health education and communicate with patients and their family members by multi-dimensional nurse. After 3 months intervening, compared patients′quality of life, the care behavior of caregivers and acquisition of knowledge of pressure scores, the incidence of pressure ulcers, degree of satisfaction of high-risk patients and caregivers between the two groups. Results The psychological function score, social function score and quality of life score was respectively ( 67.61 ± 1.67), (58.60 ± 1.52), (50.41 ± 2.70) points in experimental group, and (63.21 ± 1.30), (53.23 ± 1.92), (45.83 ± 2.59) points in control group, the comparative difference of the two groups was statistically significant( t=-4.638,-4.930,-2.749, P<0.05). There was no significant difference in the material life and body function score between two groups(P>0.05). The care behavior of caregivers score and pressure sores knowledge score was respectively (50.84 ± 1.92), (27.83 ± 1.48) points in experimental group, and (46.43 ± 2.40), (19.28 ± 1.31) points in control group, the comparative difference of the two groups was statistically significant (t=-3.192,-9.738, P<0.05 or 0.01). The incidence of pressure ulcers was 15.9%(13/82) in experimental group, significantly lower than that in control group (50.6%, 42/83), two groups was statistically significant (χ2=22.413, P<0.01). The satisfying degree and scores of patients or caregivers for follow-up form, nursing service attitude, follow-up content and the total score was respectively (24.83 ± 3.11), (24.10 ± 2.55), (25.03 ± 2.12), (76.23 ± 2.17) points in experimental group, and (18.34 ± 1.41), (17.41 ± 1.34), (19.85 ± 1.92), (63.25 ± 3.03) points in control group, the comparative difference between two groups had statistical significance (t=-7.797--4.061, all P<0.01). Conclusions Utilizing Wechat public platform continuity of care for patients at high risk of pressure ulcers can improve the patients quality of life, reduce the incidence of pressure ulcers, improve the efficient communication of nurses and patients, and enhance the degree of satisfaction of the patients. This method is convenient, shortcut, economic, practical and worthy for clinical use and promotion .

Objective To investigate the protective effect of hypoxic-preconditioned bone marrow mesenchymal stem cells (BMSCs) on spinal cord tissue after ischemia reperfusion injury.Methods Healthy adult Sprague Dawley (SD) rats weighing 200 ～ 250 grams (g) were randomly divided into 3 groups with 6 animals in each group:The sham group received simple surgical manipulation without ischemia/reperfusion treatment;The spinal cord ischemia/reperfusion group (Control group) only received spinal cord ischemia/reperfusion surgery.The hypoxic preconditioned BMSC transplantation group (HP-MSCs group) was injected with hypoxic preconditioned BMSCs 2 days before ischemia/reperfusion.The control group,HP-MSCs group received spinal cord ischemia/reperfusion for 10 min and observed for 48 h.The permeability of the blood-spinal cord barrier was examined with Evans blue (EB),and the histomorphology changes were observed with hematoxylin and eosin (HE) staining.Results EB red fluorescence was significantly weakened in the HP-MSCs group than that in the Control group (P ＜ 0.05),and more intact motor neurons were found in the lumbar spinal cords in the HP-MSCs group than that in the Control group (P ＜0.05).Conclusions The hypoxic-preconditioned BMSCs could effectively attenuate spinal cord ischemia reperfusion injury,it may be associated with protective effect of the blood-spinal cord barrier integrity.

Objective To explore the feasibility and evaluate its efficacy of transnasal marsupialization of maxillary cyst under nasal endoscope. Methods 15 cases of maxillary cyst were treated by endoscopic marsupialization in nasal. According to the situation of maxillary cysts, the fenestration of bottom nasal was opened in 6 cases, the fenestration of inferior nasal meatus was opened in 7 cases and inferior nasaI meatus was opened through the prelacrimal duct recess in 2 cases under the nasal endoscope. With partial removal of the cyst wall, the cyst and maxillary sinus was fused into a cavity if necessary. This ensured nasal drainage through the cyst cavity and nasal cavity or maxillary sinus. Results The operations of the 15 patients were success without complications. All patients were followed up for 6 to 24 months after operation. Operation cavity to complete epithelization in 2 to 3 months, the cyst cavity drained well with no recurrence. Conclusion Endoscopic marsupialization in nasal is a feasible alternative for management maxillary cyst. It makes the procedure simple, less traumatic, quick recovery, definite curative effect and low recurrence rate.