With the increase in the incidence rates of obesity and other metabolic syndromes, nonalcoholic fatty liver disease (NAFLD) has become one of the most common chronic liver diseases. More and more studies have shown that NAFLD is one of the risk factors for hepatocellular carcinoma (HCC), but the mechanism of NAFLD in HCC remains unclear. Recent studies have found that intestinal microflora imbalance, inflammatory response, adipokines, insulin resistance, hyperinsulinemia, adipose progenitor cells, and genetic mutation are involved in the development of NAFLD-related HCC. Major treatment methods for NAFLD include exercise and diet intervention, insulin sensitizer, antioxidants, probiotics, and lipid-lowering drugs. However, it is still unknown whether these methods can effectively prevent NAFLD-related HCC. This article reviews recent advances in the prevalence, pathogenesis, prevention, monitoring, and screening of NAFLD-related HCC.

Objective:To study effects of multilevel nutritional support based on Nutrition Risk Screening (NRS 2002) on nutritional status and prognosis of patients with craniocerebral tumor surgery.Methods:A total of 40 patients undergoing craniocerebral tumor surgery who were admitted to The Third People's Hospital of Hubei Province from November 2018 to October 2019 were included as the control group. A total of 40 patients undergoing craniocerebral tumor surgery who were admitted to the Third People's Hospital of Hubei Province from November 2019 to November 2020 were included as the observation group. The control group was given routine nutritional support, and the observation group was given multi-level nutritional support based on NRS 2002. The nutritional status, serum nutritional indexes, prognosis and complications were compared between the two groups before the intervention and one month after the intervention.Results:After 1 month of intervention, the thickness of triceps skinfold and muscle circumference of unaffected upper arm in the two groups were greater than those before intervention, and those of the observation group were greater than the control group, and the differences were statistically significant ( P<0.05) . The levels of prealbumin, albumin and hemoglobin in the two groups were higher than those before the intervention, and the observation group were higher than the control group, and the differences were statistically significant ( P<0.05) . The Glasgow score and ability of daily living score of the two groups were higher than those before the intervention, and the observation group were higher than the control group, and the differences were statistically significant ( P<0.05) . After 1 month of intervention, there were no statistically significant differences in body mass index, constipation, diarrhea, pulmonary infection and malnutrition between the two groups ( P>0.05) . Conclusions:Multilevel nutritional support based on NRS 2002 can improve the nutritional status and prognosis of patients undergoing craniocerebral tumor surgery and the application effect is good.