A standardized near-drowning procedure was carried out on 16 adult normal sheep. Six milliliter sea water/kg body wt were introduced into the trachea by a tube. Ten minutes after near-drowning, eleven sheep were treated with HFV(HFVgroup), and the other 5 without HFV(NHFV group). Before near-drowning and at 5,15,30,40, 70,and 130 minutes afterward the measurement were made and it was found that: 1. Serum lipoperoxide(LPO) decreased for a short time, and then increased ten folds in both groups. 2. TXB_2 and 6-keto-PGF_(1?) increased in both groups. 3. pH decreased in NHFV groups(7.133—7.219). 4. PaO_2 decreased much mose in NHFV group. 5.PaCO_2 increased slightly at 5, 15 minutes after near-drowning; 6.K~+, Na~+, CI-increased slightly in both groups, and then returned to normal at 70 minutes after near-drowning. In HFV group; the changs of pulmonary ultrastructure after near-drowning were similar in both groups. The authors concluded that HFV showed some effects but is not satisfactory. We must find other treating methods to improve survival rate.

The study was to observe the therapeutic effect of HJ-1 NO--HFJV respirator on treating pulmonary edema caused by seawater drowning. Seawater was infused into the rabbit's lung to establish the animal model of pulmonary edema caused by seawater drowning(PE-SWD). Then the animals were divided into three groups: simple PE-SWD model as control group, treat group(animal model treated with HFJV respirator and four medicines) and HFJV respiratior plus NO group. Pao2, Sao2 and pH were measured by the blood-gas analyzer. The survival time and seawater drowing-respiratiory distress syndrom(SW-RDS) were observed. The results showed that Pao2, Sao2 in NO group were remarkably higher than that of PE-SWD control group, and the survival time was longer than that of medicine treated group and the incidence of SW-RDS decreased to zero. We assume that HJ-1 NO-HFJV respirator is efficient on treating pulmonary edema.
Animals ; Disease Models, Animal ; High-Frequency Jet Ventilation ; instrumentation ; Near Drowning ; complications ; Nitric Oxide ; therapeutic use ; Pulmonary Edema ; etiology ; therapy ; Rabbits