Objective To study the laparoscopic uterine artery occlusion effect of assisted myomectomy for ovarian function.Methods 90 cases of existing operation indications ofuterine leiomyoma patients were selected as the research objects and divided into 45 cases of the control group and 45 cases of the study group.The control group received laparoscopic uterine myomectomy,the study group received laparoscopic uterine artery occlusion assisted laparoscopic myomectomy comparison between the two groups,the curative effects of the patients with operation and influence on ovarian function and sexual function.Results In the control group,the operation time (72.03 ± 13.53) min was longer than that of the study group(60.05 ± 10.32) min(t =4.722,P ＜0.05);control group,amount of bleeding during the operation was (125.43 ± 17.69) mL,more than that of the study group (82.46 ± 13.89) mL (t =12.816,P ＜ 0.05);the two group of exhaust time after operation (t =0.711,P ＞ 0.05) the time of hospitalization and postoperative (t =0.466,P ＞ 0.05) showed no significant differences.The control group after 3 months of follicle stimulating hormone (FSH),estradiol (E2) were (6.08 ± 1.35) U/L,(80.31 ± 5.36) pmol/L,the study group after 3 months of FSH,E2 were (6.85 ± 1.42) U/L,(72.39 ± 5.35) pmol/L,the difference between the two groups was statistically significant(t =2.636,t =7.015,P ＜0.05);sexual function in patients of the two groups after scores were significantly higher than those before operation,there were no statistically significant differences between the two groups (P ＞ 0.05).Conclusion Laparoscopic uterine artery blocking effects of laparoscopic assisted myomectomy in patients with ovarian function can recover quickly,safely and reliably.

Objective To identify the association of thyroid stimulating hormone receptor ( TSHR ) gene intron 1 susceptible loci and 4p14 susceptible locus rs6832151 polymorphisms with Graves’ disease ( GD) in Han Chinese population in Bengbu, Anhui, China. The gene-gene interaction among TSHR intron 1 susceptible loci and 4p14 susceptible locus rs6832151 was also investigated. Methods The genotypes of the single-nucleotide polymorphisms ( SNPs) were analyzed by Taqman probe technique on Fluidigm EP1 platform in 611 patients with GD and 555 control subjects, and linkage analysis, correlation analysis, haplotype analysis, and epistasis analysis with them were performed. Results Six SNPs in two candidate genes(rs12101261, rs4903964,rs179247, rs2284722 and rs17111394 in TSHR, rs6832151 in 4p14) were associated with GD (all P<0. 05). The frequency distributions of haplotypes of SNPs in TSHR intron 1 ( AGTA, GGCG, AATA, and CC) were significantly different between GD and control groups(all P<0. 01). There existed the interactions between rs179247 and rs12101261 in TSHR(P=0. 001) and among rs179247(TSHR),rs4903964(TSHR) and rs6832151(4p14) (P=0. 001). Conclusions rs683215 in 14p14 and rs12101261, rs4903964, rs179247, rs2284722 and rs17111394 in TSHR intron 1 were susceptible loci of GD in the Chinese Han population from Bengbu. The haplotypes in TSHR intron 1 were associated with GD. There exists the interaction between the SNPs in TSHR and 4p14,which may change the risk of GD.

Objective: To assess the effects of different nutritional support methods on postoperative recovery in patients with gastric cancer. Methods: 98 patients who received radical gastrectomy were divided into three groups: parenteral nutrition group (PN group) (n=36), early enteral nutrition group (EEN group) (n=33) and early oral feeding group (EON group) (n=29). Tolerance of enteral nutrition, postoperative recovery and economic indicators were compared. Results: The number of laparoscopic-assisted surgeries was 18, 17 and 25 in PN group, EEN group and EON group, respectively. There was no significant difference in sex, age and body mass index(BMI) among the three groups. Gastrointestinal function recovered slowly in 3 cases, including 2 cases in EEN group and 1 case in EON group. 1 case in EON group had abdominal hemorrhage. Median postoperative hospital stay in PN, EEN and EON group was 11.0, 11.0 and 8.0 days respectively, and significant reduction can be found in EON group(P<0.001). The complication rates were 30.5% (11 cases), 12.1% (4 cases), and 13.8% (4 cases), respectively, with no statistically significant difference(P=0.102). The median nutritional support costs for PN group, EEN group, and EON group were 4 543.3, 974.2, and 265.0 yuan, respectively. The median albumin consumption was 90.0, 40.0, and 0 g, respectively. The EON groups were significantly lower (P<0.001). The results of the laparoscopic assisted subgroup and the ones of whole group were consistent. Conclusion Compared with parenteral nutrition and early enteral nutrition, early oral feeding can reduce the amount of albumin consumption, decrease the cost of nutrition support and shorten the average hospital stay after surgey without increasing the incidence of complications.