Objective To discuss the clinical value of high-sensitivity C-Reactive protein ( hs-CRP) and Interlukin-6 (IL-6) on patients with diabetes mellitus and athero sclerosis. Methods Serum hs-CRP is measured through particle enhanced immuoturbidimetric method by using analysis instrument 7200 . LDL-C is examined by one-step method. IL-6 is measured by double antibody assay. Results (1) Diabetic with higer LDL-C: the density of serum hs-CRP is (6. 81 ?3. 32) mg/L. IL-6 is (17. 2 ?5. 6) mg/L . Both are remarkably positive related. related coefficient r = 0. 61 ;P 0. 05). Conclusion For diabetic serum IL-6 plays roles in inducing the synthetic of CRP when there is an acute liver and also plays roles in the pathologic process of diabetes athero sclerosis.