Objective　To introduce the development of therapy of hilar cholangiocarcinoma. Methods　This summarization paper was made on the literatures review. Results　Extended radical resection, neoadjuvant chemotherapy, orthotopic liver transplantation, photodynamic therapy and molecular chemoradiotherapy might improve the survival rate. Conclusions　Surgical resection combined with other theraputic methods is the main treatment for hilar cholangiocarcinoma.

An embryo of 4.3 mm is described. It comes to the laboratory in 10 per cent for-malin as an intact chorion measuring 22 by 16 mm. The embryo is in the shape of theletter C, and its tail is curved. The limb buds are round in shape. There are 4pharyngeal pouches, the 4th being very small. Between the bases of the 1st and 2ndbranchial arches, in the floor of the pharynx, the tuberculum impar has developed. Theotic vesicles are slightly elongated sacs and no longer connected with the covering ecto-derm. The eyes are represented by the optic vesicles and the thickened ectodermal an-lage of the lens. Trachea is still largely a groove in the ventral wall of the pharynx andesophagus. The heart is still in the so-called S shaped stage; the atrium lies on the leftside of the bulb, and has not yet doubled; the sinus venosus is not completely out ofthe septum transversum; in the atrium, near the sinus venosus, the endothelial tube isclosely attached to the wall. There are 4 pairs of aortic arches: the lst pair breaks intocapillaries imbedded in the mandible. The other three join the dorsal aortae which runcaudal and finally unite to form one median dorsal aorta. The anterior cardinal, pos-terior cardinal, common cardinal and vitelline veins, etc. are all paired and symetricallyarranged. The embryo herein described falls in group Ⅷ of Streeter.

Adult ; Humans ; Male ; Middle Aged ; Mining ; Molybdenum ; Pulmonary Ventilation ; physiology ; Radiography, Thoracic ; Respiratory Function Tests ; Silicosis ; diagnostic imaging ; physiopathology

Objective:To explore influence of rehabilitation exercise on daily living capacity in aged patients with chronic heart failure (CHF) .Methods :A total of 60 aged CHF patients were randomly and equally divided into rou‐tine treatment group (received routine CHF treatment and nursingcare ) and rehabilitation exercise group (received rehabilitation exercise based on routine treatmentgroup ) .Brain natriuretic peptide (BNP) level ,left ventricular e‐jection fraction (LVEF) ,daily living capacity and 6min walking distance (6MWD) were measured and evaluated in both groups at hospitalization and six weeks after treatment .Results:After six‐month treatment ,BNP level signifi‐cantly reduced and LVEF significantly rose in both groups ,and there were significant rise in 6MWD and daily living score in rehabilitation exercise group ,P<0.05 or <0.01 ;compared with routine treatment group ,there was signif‐icant reduction in BNP level [ (525.3 ± 113.2) pg/ml vs .(252.2 ± 114.5) pg/ml] ,and significant rise in LVEF [ (43.46 ± 9.12)% vs .(47.24 ± 8.46)% ] ,6MWD [ (286.6 ± 46.2) mm vs .(582.5 ± 55.3) mm] and daily living score [ (65.12 ± 17.6) scores vs .(82 ± 14.8) scores] in rehabilitation exercise group , P<0.05 or <0.01. Conclu‐sion:Rehabilitation exercise can significantly improve heart function ,raise daily living capacity in aged patients with chronic heart disease .

Ear Diseases ; complications ; Ear, Inner ; Female ; Hearing Loss, Sudden ; etiology ; Hemorrhage ; complications ; Humans ; Middle Aged

Antineoplastic Agents ; therapeutic use ; Colorectal Neoplasms ; drug therapy ; genetics ; metabolism ; Genes, ras ; genetics ; Humans ; Lung Neoplasms ; drug therapy ; genetics ; metabolism ; Molecular Targeted Therapy ; methods ; Mutation ; Neoplasms ; drug therapy ; genetics ; metabolism ; Pancreatic Neoplasms ; drug therapy ; genetics ; metabolism ; Proto-Oncogene Proteins ; genetics ; metabolism ; Proto-Oncogene Proteins p21(ras) ; Receptor, Epidermal Growth Factor ; drug effects ; metabolism ; Signal Transduction ; ras Proteins ; genetics ; metabolism

0.05).Conclusion The standard test methods are more effective in detecting G.lamblia than C.parvum.No G.lamblia and C.parvum contamination has been found in drinking water in the Tianjin and Shenyang.

Objective To establish a polymerase chain reaction method for the detection of the rcp virulence gene of L. pneumophila. Methods Sixteen strains of Legionella pneumophila, L. dumiffii, L. bozemanii and L. Longbeachae isolated from the cooling towers of the centralized air-conditioning systems in Tianjin form 2005 to 2007 were detected by polymerase chain reaction method using L. pneumophila rcp virulence gene-specific primer according to GenBank published nucleotide sequence. Results The 900 bp rcp genetic fragment was amplified in three strains of L. pneumophila, while others not. Conclusion The rcp virulence gene-based polymerase chain reaction method for the detection of L. pneumophila has been successfully established and is the foundation for the studies of Legionella virulence.

Objective To systematically evaluate the effects of the different postoperative exercise programs on the rehabilitation (such as shoulder range of motion,the incidence of the lymphedema and postoperative complications) of breast cancer patients.Methods The relevant randomized controlled trials which were retrieved from January 2008 to October 2013 were searched in the databases of the Pubmed,Embase,Ovid,Cochrane Library,China Biomedical Literature Database (CBM),China National Knowledge Infrastructure (CNKI),Wanfang Data,VIP.Two reviewers independently screened the literature according to the inclusive and exclusive criteria,extracted the data,and assessed the quality.The RevMan 5.2 software was used for Meta-analysis.Results Finally 10 randomized controlled trial involving 1 110 patients were included.The Metaanalysis showed that progressive exercise program compared to usual exercise obviously modified the shoulder anteflexion [MD =33.04 (26.85-39.23) and 28.05 (21.81-34.30)],abduction [MD =31.06 (8.17-53.95) and 31.39(24.96-37.82)],extorsion [MD=18.47(13.44-23.50) and 16.02(8.35-23.68)] 1 month and 3 months after surgery (P＜ 0.05),extension 1 month after surgery,adduction 3 months after surgery.It also decreased the incidence of the lymphedema.Conclusions It gives us some evidence that the progressive exercise program can promote the rehabilitation of the postoperative breast cancer patients.

Objective To observe the dynamic levels of IL-2,IL-5 and IL-6 produced by Balb/ c mice infected with DEN_2 clinical strains and to study their relation.Methods The Balb/c mouse in- feetion model was established by multiple-site subcutaneous injection with various doses of DEN_2 clini- cal strain.Mouse plasma samples collected from different experiment groups at various time after in fection were tested for IL-2,IL-5 and IL-6 levels with sandwich ELISA.Results After primary in- feeted with DEN_2 B strain,the levels of IL-2,IL-5 and IL-6 of all experimental groups were not sig- nificantly higher than the normal control group while the levels of experimental groups increased sig- nificantly after re-infection.The level of IL-2 reached to peak[average value of(101 522.44?10 465.375)pg/ml]at the 4th day after re-infection(the 20th day after the primary infection),and then the level gradually reduced.The levels of IL-5 in the Balb/c mice of the group 1 and 2 reached to peak at the 1st day after re infection(the 16th day after the primary infection),and there was signifi- cant difference between these two groups and the control group(P＜0.05).The levels of IL-6 in all experimental groups reached to peak at the 1st and the 2nd day after re-infection.The peak value of the third group is the highest comparing with the normal control group(P＜0.05).Conclusion Th2 response was predominant in the second infection phase.