Objective To investigate the therapeutic effect of osteoporotic vertebral compression fractures treated by percutaneous kyphoplasty combined zoledronic acid.Methods Patients admitted to our hospital′s depart-ment of orthopedics from February 2010 to December 2013 were reviewed,and 67 patients underwent percutaneous ky-phoplasty were admitted.According to the application of zoledronic acid or not,they were divided into 2 groups,with 39 cases and 28 cases,respectively.On 67 patients before surgery,3 days after surgery,the end of follow -up surgery, VAS,ODI,vertebral height average recovery rate and Cobb angle were compared.The BMD was also compared before and after surgery.Results There was no difference between the two groups in all above indices before treatment(t =0.308,P =0.758;t =0.476,P =0.635;t =0.397,P =0.693;t =0.342,P =0.733).3 days after surgery,the levels of VAS,ODI and Cobb angle all decreased(t =25.820,P <0.001 vs.t =24.988,P <0.001;t =16.801,P <0.001 vs.t =17.008,P <0.001;t =9.717,P <0.001 vs.t =7.525,P <0.001),while vertebral height average recovery rate were increased in both groups(t =8.300,P <0.001 vs.t =6.363,P <0.001 ),but there was no difference between the two groups(t =0.177,P =0.861;t =0.568,P =0.572;t =0.453,P =0.652;t =0.508,P =0.613).In the end of follow -up surgery,there was a significant difference between the two groups(t =4.779,P <0.001;t =7.041,P <0.001;t =2.517,P =0.014;t =2.406,P =0.019).There was no difference between the two groups in BMD(t =0.479,P >0.05),but it came to be a difference between the two groups in the end(t =2.710,P =0.009), although there was no difference in secondary fracture(23.1% vs.7.1%,χ2 =3.016,P =0.082).Conclusion Per-cutaneous kyphoplasty combined zoledronic acid has an excellent effect on osteoporotic vertebral compression frac-tures,it is worthy promoting.

Recently the lysine succinylation was discovered in vivo, and it was demonstrated to be widely involved in cell dif-ferentiation, cell metabolism and other important physiological activities.Lysine succinylation has become the forefront of life science research.Scientists have provided a lot of evidences that proteins in prokaryotes and eukaryotes are widely succinylated, without which the central metabolism and intermediary metabolism of many metabolic enzymes are disrupted.To better understand the importance of Succinylation in vivo, protein-succinyl modification of the current research and the latest developments are reviewed, which summarize succinylated protein lysine sites in the center of important physiological metabolic pathways, diseases and other pathological conditions.

THe insulin-like growth factor(IGF) system,a very important polypeptide growth hormone,has been found to have some relation with primary adrenocortical tumorigenesis and modulates its growth.This article reviews the general biological characteristics of IGF and the relations of the IGF system with the normal adrenal cortex and primary adrenocortical tumor.It also and discuss the clinical meaning of its possible presence in the primary adrenocortical tumor.

Head and neck cancer presents with complex anatomy and high intratumoralheterogeneity. Radiotherapy is one of the main treatments. The therapeutic strategy and prognostic evaluation in head and neck cancer patients traditionally depend on TNM stage, lacking of individual information. Radiomics can extracts high-throughput image features relevant to the biology of tumors, which provides a non-invasive and quantitative method to evaluate the overall tumor heterogeneity and also offers a novel perspective for precision radiotherapy. The research progresses on the application and chanllenges of radiomics in the radiotherapy for head and neck cancer were summarized in this review.

Antimalarials ; therapeutic use ; Artemisinins ; therapeutic use ; Child ; Drug Therapy, Combination ; Humans ; Malaria, Falciparum ; drug therapy

Objective To assess the prevalence of gastroesophageal reflux disease(GERD) in the population of Fujian province, and to analyze the risk factors in relation to the disease. Methods A survey on GERD symptoms and its related factors was carried out in the population of Fuzhou city in Fujian province using a stratified random sampling method. According to reflux disease questionnaire (RDQ) score, the subjects were divided to GERD group with Sc≥ 12 and control group with Sc＜ 12.The risk factors related to GERD were compared between two groups. Results A total of 1347residents were investigated. The prevalence of GERD was 8.76 %, and male to female ratio wasincreased in population above 40 years of age (P＜0.05). The incidence of GERD in subjects with different occupations was as follows: the businessmen [17.91%(12/67)], retirees [13.48%(12/89)]and soldiers [2.94%(2/68)]. Symptoms including abdominal distension, belching, nausea, vomiting,dyspepsia were common in GERD group compared to control group (P ＜ 0.01). Besides, the laryngitis, pharyngitis and mouth ulcer were common in GERD group compared to control group ( P＜0.05). The risk factors of GERD were eating greasy (OR= 1.589) and sweetmeat (OR= 2.413),overeating (OR = 2.053), constipation (OR = 1.650), acridity food (OR = 1.366 ), coffee (OR =1.295), strong tea (OR= 1.362). Conclusions The prevalence of GERD is high in the population of Fujian province, and many factors are closely related to reflux.

Objective To observe the results of function MRI and perimetry in patients with visual pathway diseases. Methods Three patients (6 eyes) with pituitary adenoma and craniopharyngioma diagnosed via pathological examination and three healthy volunteers aged from 24 to 30 were collected. The best corrected visual acuity was non-light perception-1. 0 in the 6 sick eyes and 1. 0 in the healthy eyes;all the involved individuals had no other ocular diseases except myopia and without any contraindications of MRI. Common tests including the best visual acuity, fundus test by direct or indirect ophthalmoscope, center static visual field tested by Octopus 101 perimeter, program 32, tendency oriented perimetry were performed. The visual stimulation subtended a field of view of about 12 degrees,consisted of high contrast and drifting checkerboards. MRI parameters: GE signa VH/i 3. 0T scanner. Functional data: GRE-EPI sequence, 20 slices lying perpendicular to the calcarine sulcus. Anatomical data was obtained using 3DSPGR sequence to acquire high resolution. The cortical surface was unfolded and then cut and inflated. Functional data was presented to the inflated surface and subsequently analyzed by AFNI software. Results In six eyes, three had temporal defects, two had upper temporal visual field defects, and the other one did not finish the visual field test. The retinotopic representations of health adults were obtained by using the phase-encoded visual stimulation. The Eccentricity coordinate maps showed that foveal representations lay in the occipital poles and the representations appeared further anterior as eccentricity increased. The polar angle coordinate maps showed that early retinotopically organized areas had a representation of visual field. The visual cortex beneath the calcarine sulcus matched with the upper visual field of the opposite side and which upon the calcarine sulcus matched with the under visual field of the opposite side. Less or no visual cortex response was revealed in the patients' function MRI or the response in injury side was vanished. The visual cortex response related with the visual field defects could not be induced in function MRI. Conclusion There is a good correlation between function MRI data and the results of perimetric evaluation. The function MRI can show the visual cortex response correlated with the visual field defects of the patients with visual pathway diseases.

Breast Neoplasms ; metabolism ; pathology ; surgery ; Carcinoma, Intraductal, Noninfiltrating ; metabolism ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Mastectomy ; methods ; Neoplasm Invasiveness ; Sentinel Lymph Node Biopsy ; Survival Rate

Objective To assess the prevalence and related factors of gastroesophageal reflux disease (GERD) in troops stationed in southern China. Methods An investigation with validated questionnaire and stratified random sampling method was carried out in troops stationed in southern China to survey the prevalence of GERD and its related factors. According to the definition of reflux disease questionnaire (RDQ) score,the severity and frequency of the dominant symptoms of GERD,such as heartburn,acid regurgitation,food reflux and non-cardiogenic chest pain were scored. People with score equaled to and higher than 12 (Sc≥12) were assigned to patient group,and those with score lower than 12 (Sc0.05). Subjects in the patient group had a higher incidence of abdominal distension,belching,nausea,vomiting,abdominal pain compared with control group. A higher incidence of laryngitis,pharyngitis and ulcerative stomatitis (P

Aim To investigate the changes of phosphorylated p38 mitogen-activated protein kinase(p-p38MAPK)in the spinal cord following chronic compression of dorsal root ganglion(CCD)in rats, and to explore the correlation between chronic neuropathic pain and p38MAPK.Methods The animal model of neuropathic pain following chronic compression of dorsal root ganglion was established.36 male Sprague-Dawley rats were randomly divided into Naive group(n=4),Sham group(n=16),CCD group(n=16).Sham group and CCD group were also divided into 5,7,14 d and 21 d group respectively(n=4),Western blot analysis was used to investigate the expression of the phosphorylated active form of p38MAPK (p-p38MAPK) in the spinal dorsal horn in rats after CCD.Results p-p38MAPK protein was expressed in spinal cord among all three groups,but there were no significant differences between Naive group and Sham group.Compared to Naive and Sham group, rats in CCD group showed significant increase of the expression of p-p38MAPK protein in spinal cord.Compared with that of Sham group,protein expression of p-p38MAPK in cytosol in the spinal dorsal horn in 5,7,14 d and 21 d of post-surgery increased respectively 138.1%(P