To compare posterior choroidal thickness in high myopia amblyopia eyes at different points to high myopia and normal eyes of Chinese children and investigate the relationships between choroidal thickness, axial length and age.METHODS: Fifty Chinese children (65 eyes) with age 4~15 years ( mean 9. 91 ± 3. 41 years) were recruited. By atropine optometry they were divided into high myopia amblyopia group ( 24 eyes ) , high myopia group ( 19 eyes ) , and normal group ( 22 eyes ) . Choroidal scans were obtained for all eyes using enhanced depth imaging spectral-domain optical coherence tomography ( EDl-OCT) . Subfoveal choroidal thickness (SFCT), macular thinkness, choroidal thickness and retinal thickness at 0. 5, 1. 0, 1. 5, 2.0, 2.5, 3.0mm superior (S, 12:00 position), temporal ( T, 9:00 position) , inferior ( l, 6:00 position) , nasal ( N, 3:00 position) were measured. Meanwhile, axial lengths of all eyes were measured by A-Scan. RESULTS: Compared high myopia group and emmetropia group, SFCT and the thickness of choroids on each position were thinnest in high myopic amblyopia group, with statistically significant differences (P<0. 05). There was a significant negative correlation between SFCT and axial length in high myopic amblyopia group (r=-0. 531, R2 =0. 282, F=7. 476, P=0. 013), with no relative in age (r=-0. 292, R2=0. 085, F=2. 044, P=0. 167).CONCLUSlON: The choroidal thickness thinning in high myopic amblyopia shows a negative correlation with axial length.

·AlM:To investigate the retinal thickness change of high myopia amblyopic children, so as to discuss the relationships between the retinal thickness of central fovea of macula and the factors of axis oculi and age. · METHODS:Thirty-nine children ( 65 eyes ) with the average age of ( 9.91 3.41 ) years were recruited.All eyes were ruled out the pathological changes of fundus diseases and front section. After a tropine optometry, they were divided into three groups: high myopia amblyopic group ( 24 eyes ) , high myopia group ( 19 eyes) and normal group ( 22 eyes ) .Retinal scans were obtained for all eyes using Heidelberg optical coherence tomography ( OCT ) . Subfoveal macular thickness, retinal thickness at 0.5mm, 1.0mm, 1.5mm, 2.0mm, 2.5mm, 3.0mm superior ( S, 12∶00 position), temporal (T, 9∶00 position), inferior (l, 6∶00 position) and nasal (N, 3∶00 position) from the fovea were measured and axial length was also surveyed by A -ultrasound. Statistical analyses were performed to evaluate retinal thickness at each location and to correlate subfoveal macular thickness with axial length and age.
·RESULTS:The average subfoveal macular thinkness of the high myopia amblyopic group was thinner than high myopia group but thicker than normal group.There was no statistical difference between three groups (P>0.05). Retinal thickness inferior to the fovea at 0.5mm temporal and superior to the fovea in the high myopia amblyopic group at 1.0mm temporal were both thinner than normal group which had statistically significant ( P <0.05 ). Retinal thickness on nasal, superior, temporal, and inferior at 1.5mm, 2.0mm, 2.5mm, 3.0mm from the fovea were measured, high myopia amblyopic group were the thinnest in the three groups, and there was statistically significant between three groups ( P<0.05). There was no correlation between the average subfoveal macular thickness and axial length, age in high myopia amblyopic group.
· CONCLUSlON:There are significant abnormalities of macula retinal structure in high myopia amblyopic children.

AIM: To research the peripapillary retinal nerve fiber layer ( RNFL ) thickness change in high myopia amblyopic children and to discuss the relationships among RNFL thickness, axial length and age.
METHODS:Thirty-five Chinese children (59 eyes) with a mean age of ( 9. 59 ±2. 90 ) years were recruited. All eyes were ruled out the pathological changes of fundus diseases and front section. By atropine optometry after they were divided into: high myopia amblyopia group (22 eyes), high myopia group (15 eyes), normal group (22 eyes) . RNFL scans were obtained for all eyes using optical coherence tomography and axial length was also surveyed by A - ultrasound. Statistical analyses were performed to evaluate RNFL thickness at each location with axial length and age.
RESULTS:The peripapillary RNFL thickness in temporal of high myopia amblyopia group was thinner than that in
high myopia group, and thicker than that in normal group. The peripapillary RNFL thickness in nasal, superior, inferior and the average thickness of high myopia amblyopia group were thinner than those in high myopia and normal gruops. The peripapillary RNFL thickness in inferior and average thickness of high myopia amblyopia group were significantly thinner than those of high myopia (P<0. 05). The peripapillary RNFL thickness in nasal, superior, inferior and the average thickness of high myopia amblyopia group were significantly thinner than those of normal (P<0. 01). The peripapillary RNFL thickness in temporal of high myopia group was significantly thicker, and in nasal, superior, inferior and the average thickness were significantly thinner than those of normal (P<0. 05). The thickness of peripapillary RNFL in inferior showed a negative correlation with axial length in high myopia amblyopia group (R=0. 474, R2=0. 225, F=4. 933, P=0. 040). The thickness of peripapillary RNFL in superior showed a negative correlation with axial length in high myopia group (R=0. 642, R2=0. 412, F=9. 104,P=0. 010). These were no correlation between the peripapillary RNFL thickness and age in high myopia amblyopia, myopia amblyopia and normal.
CONCLUSION:There are significant abnormalities of retinal structure in high myopia amblyopia.

Human adenovirus (HAdV) is one of the most important pathogens in infants and young children with acute respiratory infections and other diseases. This article reviews the literature on HAdV, including its molecular biological characteristics, detection and typing, and pathogenic mechanism, the clinical features and epidemiological characteristics of HAdV-related diseases, and the prevention and control of HAdV infections. So far, 67 types of HAdV have been identified, including recombinant variants discovered in recent years. The major epidemic strains that cause acute respiratory infections are HAdV-3 and HAdV-7, both of which belong to the subgroup B. HAdV often leads to acute respiratory infections, but it also causes diseases of other systems. HAdV-related diseases have similar clinical manifestations as those caused by other respiratory viruses, but often accompanied by gastrointestinal symptoms. The pathogenic mechanism of HAdV remains unclear, especially for the new recombinant variants, due to few studies on their association with diseases. Because there are no prospective, large randomized controlled trials of HAdV infections, the treatment of HAdV infections is controversial. Vaccine is the most effective measure to reduce respiratory HAdV infections, but it is still not commercially available.
Adenovirus Infections, Human ; virology ; Adenoviruses, Human ; classification ; genetics ; isolation & purification ; physiology ; Animals ; Humans

Adult ; Aged ; Aged, 80 and over ; Antifungal Agents ; therapeutic use ; Female ; Hematologic Neoplasms ; drug therapy ; microbiology ; Humans ; Male ; Middle Aged ; Mycoses ; complications ; drug therapy ; Pyrimidines ; therapeutic use ; Treatment Outcome ; Triazoles ; therapeutic use ; Voriconazole ; Young Adult

Aged ; Castleman Disease ; complications ; Hepatitis B ; complications ; Humans ; Liver Neoplasms ; complications ; virology ; Lymphoma, Non-Hodgkin ; complications ; Male

Acute Disease ; Adult ; Aged ; Female ; Humans ; Lipid Peroxidation ; Male ; Malondialdehyde ; blood ; Middle Aged ; Organophosphate Poisoning ; Oxidative Stress ; Superoxide Dismutase ; blood ; Xanthine Oxidase ; blood ; Young Adult

Adolescent ; Humans ; Leukemia, Myeloid, Acute ; etiology ; pathology ; Male ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; complications ; pathology

Acute Disease ; Adult ; Aged ; Aryldialkylphosphatase ; blood ; Female ; Humans ; Male ; Middle Aged ; Organophosphate Poisoning ; Young Adult

OBJECTIVETo observe the changes of the mechanical pain threshold in the rat model of autoimmune prostatitis, explore the mechanism of autoimmune prostatitis pain and offer some animal experimental evidence for the drug therapy of the condition.

METHODSTwenty male Wistar rats weighing 180 - 220 g were divided into a model and a control group. The autoimmune prostatitis model was established by subcutaneous injection of an extract of male rat prostate glands (RPG) at 60 mg/ml in Freund's complete adjuvant (FCA) and pertussis-diphtheria-tetanus vaccine at 0 and 30 days, respectively. Mechanical tactile hyperalgesia was measured once a week using Von Frey Filaments from the beginning of the study. At 8 weeks after modeling, the rats were sacrificed and the prostate tissues harvested for observation of histomorphological changes by HE staining.

RESULTSHE staining revealed different degrees of benign prostatitis in the model rats. Compared with the controls, the mechanical pain threshold in the model rats was significantly decreased with the increased time of modeling, from (65.52 +/- 6.27) g at 0 week to (23.67 +/- 4.09) g at 8 weeks (P < 0.01). Statistically significant differences were found in the variation trend at different time points between the two groups (P < 0.01).

CONCLUSIONAutoimmune prostatitis models were successfully established in rats and hyperalgesia was induced after modeling.

Animals ; Autoimmune Diseases ; physiopathology ; Disease Models, Animal ; Male ; Pain Threshold ; physiology ; Prostatitis ; immunology ; physiopathology ; Rats ; Rats, Wistar