Choroidal neovascularization (CNV) can be classified into different types based on the etiology, positions with the retinal pigment epithelium, distance to the geometric center of the foveal avascular zone, fundus fluorescein angiography and indocyanine green angiography. Subtypes of CNV are also existed. The different classifications have different clinical significances. Comprehend the classification of CNV has important value in evaluating the lesions and guideline for treatment.

Objective To investigate the relationship of diabetic nephropathy with serum endothelin-1(ET-1) and C-reactive protein(CRP). Methods Levels of blood pressure, glucose, lipid, creatinine,ET-1,CRP and urinary albumin excretion(UAER) were measured and calculated in 86 patients with type 2 diabetes mellitus(T2DM)and 30 healthy subjects. Results Serum ET-1 and CRP were significantly higher in T2DM than in control(P<0.05，P<0.01).Serum ET-1 and CRP were increased with increment of serum creatinine and UAER(P<0.05，P<0.01). Conclusions Serum ET-1 and CRP may be involved in the development and progression of diabetic nephropathy.

Objective　To analyze the surgical results of uveitis-complicated cataract.Methods　Cataract phacoemulsification surgery was performed on 31 eyes (29 patients) due to uveitis (iridocyclitis 14 eyes, Fuchs heterochromic cyclitis 7 eyes, intermediate uveitis 7 eyes, Vogt-koyanagi-harada syndrome 2 eyes, and sympathetic ophthalmia 1 eye). Follow-up period was 5～28 months, averaging 15 months. Retrospective analysis was made.Results　Postoperative visual acuity≥0.5 was 80%. One eye (Vogt-koyanagi-harada syndrome) showed severe anterior uveitic reaction; One eye (iridocyclitis) had fibrinous membranes on IOL, and white debris on IOL were found in 2 eyes (intermediate uveitis).Conclusion　By using less traumatic phacoemulsification technique to ocular tissue, taking meticulous care to avoid stimulating iris, cleaning up cortex thoroughly during surgery and implanting the IOL in the bag, less inflammatory reaction, less complication and better vision acuity postoperatively at relative quiescence period of uveitis can be achieved.

Retinal hemorrhage can be divided into intravitreal, subhyaloid, subinner limiting membrane, superficial retinal, deep retinal, subretinal and subpigment epithelial hemorrhage. Each of these hemorrhages has a characteristic and recognizable appearance. Comprehending the classification and characteristic of retinal hemorrhage has important value in diagnosis, differential diagnosis and guideline for treatment.(Ophthalmol CHN, 2009, 18: 221-224)

Objective To evaluate the clinical value of selective salpingography(SSG)and fallopian tube recanalization(FTR) for diagnosis and treatment of oviduct obstructive infertility with self-made simple coaxial microtube.MethodsSSG and FTR with self-made simple Coaxial Microtube were performed for 76 cases with 134 tubes of obstructive oviduct through wire-guided tubal recanalization,anti-inflammatory and anti-adhesion effect of recanalization fluid,and the patients were treated with anti-bacterial and hydrotubation after operations.ResultsSSG displayed that 81 tubes obstruction in interstitial tubal,25 tubes obstruction in isthmus,16 tubes obstruction in ampulla and 12 tubes obstruction in fimbria.The total recanalization rate of FTR was 76.1%,with the recanalization rate 96.3% in interstitial,the recanalization rate 68.0% in isthmus and the recanalization rate 43.8% in ampulla,and no serious complications occurred.All cases were followed up for one to two years postoperatively.Normal pregnancy pationes were 31 cases(40.8%),and 29 women were normal parturition,2 cases(2.6%) were extrauterine pregnancy.ConclusionThe advantage of SSG and FTR with self-made simple coaxial microtube is low cost,simplicity and excellent efficacy.It is worth popularizing in grass-roots hospitals.

Multimodal fundus imaging techniques, based on lights and shadows, appear to have a rapidly great progress in recent years.Fundus imaging techniques are divided into anatomical approaches and functional approaches according to the working characteristics and principle of different instruments.Nowadays, fundus imaging techniques are developing toward a wide field, microview, multimodal, quantitative, and intelligent way.However, to our knowledge, the fundus is very broad with many unexplored territories and unsolved mysteries until now.The road of clinical industrialization of emerging imaging techniques is still long, and there is also a potential challenge in the application of artificial intelligence deep learning in ophthalmology.Multimodal fundus imaging techniques are beneficial for us to accurately diagnose and dynamically monitor eye diseases, but with so many examination methods, how to choose a highly sensitive and specific way to avoid the waste of medical resources and reduce unnecessary financial burden of patients is the responsibility of ophthalmologists.

Ocular fundus imaging technology has developed rapidly in the past decade. The exsiting imaging technology is constantly updated and new imaging technology emerges one after another. The related research and development investment, equipment usage and paper publication are all growing rapidly. At the same time, it is developing towards the direction of multi-technology combination, integration of artificial intelligence and big data, as well as small-size and automation use of equipment. However, there are many challenges behind the prosperity of ocular fundus imaging, such as professionally remodeling of fundus diseases knowledge system standardization, balance and independence of scholarly communication, misunderstanding of "multimodal images", validation of the effectiveness and applicability of emerging technologies, clinical imaging research innovation, original technology innovation and technology reserve, fundus imaging data integration and analysis system for the future.

Objective To evaluate the imaging features of CT and MR in patients with intraductal papillary mucinous tumor of the pancreas (IPMT).Methods Imaging findings of 10 patients with histopathologically proved IPMT were retrospectively analyzed.Of 10 cases,CT was performed in 8 patients,and MR in 6 patients.Results Eight lesions were in pancreatic head and neck,and 2 lesions were in pancreatic body and tail.The images showed the dilated pancreatic duct in all the patients,and the diameter was (0.8 ± 0.2) cm.Three patients had the dilation of branch duct,and 4 patients showed atrophy of pancreatic body and tail.The CT showed 6 cases had cystic masses with septa and mural nodules;and 2 cases had the dilation of the main pancreatic duct with intraductal mural nodules.Lesions showed low signal intensities on T1WI and high signal intensities on T2WI with septa and mural nodules,which showed moderate hypointensity on T1WI and T2WI and heterogeneous enhancement on enhanced T1WI.Conclusions There are some characteristics in CT and MR manifestation of IPMT:common in pancreatic head and neck,dilated pancreatic duct,cystic tumors with septa and mural nodules,and the enhancement of cystic wall,septa and mural nodules.The disease might be correctly diagnosed with these characteristic imaging features.

Objective To observe the imaging features of branching vascular network (BVN) in polypoidal choroidal vasculopathy (PCV).Methods Eighty PCV patients (90 eyes) were enrolled in this study.The patients included 58 males and 22 females.The age was ranged from 49 to 85 years,with a mean age of 61.4 years.All the patients were examined for fundus photography,fundus fluorescein angiography (FFA),indocyanine green angiography (ICGA) and optical coherence tomography (OCT).The fibrovascular retinal pigment epithelium detachment (PED) was defined as a well-demarcated subretinal heterogeneous plaque with increasing fluorescence on FFA.The late lichenoid hyperfluorescent plaque was defined as a well-demarcated lichenoid hyperfluorescent plaque on late phase ICGA.The double-layer sign on OCT was defined as a wide range of shallow PED from Bruch membrane.Results BVN were found on early ICGA in 76 eyes among the 90 eyes (84.4％).Among these 76 eyes,18 eyes (23.7％) demonstrated the subretinal reddish-orange branches corresponding to BVN.Fifty-six eyes (73.7％) demonstrated all or part of the BVN on early FFA.Three eyes (3.9％) demonstrated branching transmitted fluorescence corresponding to BVN throughout the FFA.Seventy-three eyes (96.1％) were manifested by occult choroidal vascularization on FFA,and 21 eyes (27.6％) of them were fibrovascular PED.Among the 76 eyes with BVN,all BVN appeared earlier than polypoidal lesions on ICGA.Polypoidal lesions located on the terminal of BVN in 62 eyes (81.6％).Sixty-nine eyes (90.8％) on ICGA demonstrated the late lichenoid hyperfluorescent plaque,whose area was equal to or greater than the area of BVN shown on early ICGA.Seventy-two eyes (94.7％) had the double layer sign.Among these 72 eyes,15 eyes (20.8％) had lumen like structure within the double-layer sign.Sixty-five eyes (90.3％) had punctate and linear hyperreflectance within the double-layer sign.Two eyes (2.8％) demonstrated a hyporeflective short segment and a gap of Bruch membrane on OCT corresponding to the origin of the BVN.Sixty-three eyes (87.5％) had an area of double-layer sign that matched the area of late lichenoid hyperfluorescent plaque on ICGA.Conclusions BVN in PCV can be noted as reddish-orange branches on fundus examination.Most of the BVN are shown as early branching transmitted fluorescence but collectively an occult choroidal vascularization on FFA,as lichenoid hyperfluorescent plaque on late ICGA,and as double-layer sign on OCT whose area matches late lichenoid hyperfluorescent plaque.

Objective To study the appearances and early fetures of sacroiliac joints(SIJ) in ankylosing spondylitis on X-ray film and CT,and to valuate the CT examination of sacroiliac joints in the same groups.Methods The plain X-ray film of 73 cases of SIJ of ankylosing spondylitis which had been proved clinicalhy were studied.All the patients had been examed with CT at the same time.The appearances presented by the two methods were concluded compared and graded,the relationship between them was analyzed with statistics.Results The erosion,cystic lesions of bone and swollen of soft tissues were the early features of sacroiliac joints in ankylosing spondylitis,but the detection rate of them by X-ray was 73%,38%,0.6%,by CT was 86%,72%,3%.They can find on CT and conventional radiography,but the detection rate of them by CT was much higher than that by X-ray plain film(?