2.Clinical Significance of Measuring Exhaled Gaseous Signal Molecules
Journal of Applied Clinical Pediatrics 1994;0(04):-
Exhaled gaseous signal molecules such as nitric oxide(NO),carbon monoxide(CO) and hydrogen sulfide(H2S) can be measured with a non-invasive technique.The fraction of NO level in exhaled gaseous of patients with airway inflammatory illness(such as bronchial asthma) significantly increases.No in exhaled gaseous is one of the markers in the diagnosis of asthma,and it is also a marker of anti-inflammatory response for patients with asthma.The fraction of CO level in exhaled gaseous of patients with bronchial asthma is also si-gnificantly elevated.Both NO and CO in exhaled gaseous in other airway inflammatory illness,such as chronic obstructive pulmonary disease,chronic bronchitis and cystic fibrosis are also evidently changed.Measuring exhaled gaseous signal molecules can provide important basis for the diagnosis and treatment of airway inflammatory illness.
3.The role of heat shock protein 70 in regulating neuroinflammation.
Wen-wen YU ; Xiu-qi BAO ; Hua SUN ; Dan ZHANG
Acta Pharmaceutica Sinica 2015;50(8):945-950
Neurodegenerative disease is characterized by progressive loss of neurons in specific brain regions that results in neuronal dysfunction of the central nervous system. Although the pathological mechanism is not fully established, the activation of glial cells mediated neuroinflammation appears to be involved. Heat shock protein 70 (HSP70) is originally described as intracellular chaperone, which plays an important role in protein quality control in cells. However, recent study showed that up-regulation of HSP70 had anti-inflammatory effects in the brain. HSP70 protected neurons from damage and improved neurological function by decreasing inflammatory response as indicated by inactivation of glial cells and inhibition of pro-inflammatory cytokine release. So it is of great significance to find new compounds targeting at HSP70 as neuroprotective agents to delay the progress of neurodegenerative disease. This review will focus on the role of HSP70 in neuroinflammation and the recent advances in using HSP70 as a target for the treatment of neurodegenerative disease.
Brain
;
physiopathology
;
Cytokines
;
HSP70 Heat-Shock Proteins
;
physiology
;
Humans
;
Inflammation
;
pathology
;
Neurodegenerative Diseases
;
physiopathology
;
Neurons
;
pathology
;
Neuroprotection
;
Up-Regulation
4.Difference in the expression of TRAIL mRNA between acute and chronic myeloid leukemia patients and its significance.
Wen-hui ZHANG ; Yin ZHANG ; Bao-gen MA
Chinese Journal of Hematology 2013;34(2):166-168
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Child
;
Child, Preschool
;
Female
;
Humans
;
Infant
;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
;
classification
;
genetics
;
Leukemia, Myeloid, Acute
;
classification
;
genetics
;
Male
;
Middle Aged
;
RNA, Messenger
;
genetics
;
TNF-Related Apoptosis-Inducing Ligand
;
genetics
;
Young Adult
5.Cognition and attitude analysis of medical workers toward public hospitals reform in Anhui
Qin ZHANG ; Bo ZHANG ; Wen BAO ; Dan WU ; Dian ZHOU
Chinese Journal of Hospital Administration 2011;27(8):561-566
A total of 1140 medical workers from 8 public hospitals of secondary and tertiary levels in Anhui were surveyed with questionnaire. Their knowledge of the reform, acknowledgement of key points of the reform, desire of participating in the reform and other factors that may influence the reform were investigated as categorized by their hospital, position, title and age. This study comes up with such recommendations as reinforcing communications on public hospital reform, reforming the compensation mechanism to clarify government responsibilities, probing into a better model for multi-institution practice of certified physicians, and encouraging private capital to participate in medical service while ensuring its non-profit nature, and improving the performance appraisal mechanism to ensure incentives of medical workers. These recommendations aim to enable the health administrators in their decision making.
6.Progress in non-invasive diagnostic model of hepatic fibrosis.
Bao-En WANG ; Ji-Dong JIA ; Wen-Sheng ZHANG
Chinese Journal of Integrated Traditional and Western Medicine 2006;26(1):5-7
Biomarkers
;
blood
;
Biopsy, Needle
;
utilization
;
Hepatitis C
;
complications
;
Humans
;
Liver
;
pathology
;
Liver Cirrhosis
;
diagnosis
;
pathology
9.Overview of CDISC standard and implementation in China.
Victor WU ; Wen-Jun BAO ; John WANG ; Rui-Ling PENG ; Ya-Zhong DENG ; Zi-Bao ZHANG
Acta Pharmaceutica Sinica 2015;50(11):1428-1433
CDISC standard has become a set of global data standards that can be used in clinical study, covering the full life cycle of clinical researches. After nearly 20 years of development and continuous version upgrades, CDISC standard can improve the quality and efficiency of clinical research and drug review, and to facilitate all stakeholders involved in researches to exchange the study data and communicate the outcomes. CDISC standard has been or is to be adopted as standard format in data submission by multiple regulatory authorities, and more widely implemented by the global pharmaceutical community. CDISC standard is gradually adopted in China. The feasibility and roadmap of CDISC standard as the Chinese data submission format requirements are undergoing exploration and piloting further.
Biomedical Research
;
standards
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China
;
Clinical Trials as Topic
;
standards
;
Data Collection
;
standards
10.A Convenient Method to Select DNA Fragments of Cephalosporium acremonium with Promoter Function
Pi-Yan ZHANG ; Chun-Bao ZHU ; Bao-Quan ZHU ; Wen-Jie ZHAO ;
Microbiology 1992;0(03):-
A promoter-trap vector pGBT14 for selecting promoters of fungus gene was constructed with E. coli-yeast shuttling plasmid pGBT9. Using this vector, a0. 5-2. 0kb chromosomal DNA library of Cepholosporium acremonium was constructed, and twenty four DNA fragments with promoter function in Saccharomyces oerevisiae Y153 were selected from this DNA library. And the promoter function of these DNA fragments was analyzed.