Objective To study the role of cyclcoxygenase-2 in the growth and development of the endome-trial lesions. Methods The expression of cycloogxygenase-2 (COX-2) were tested by immunohistocbemistry. Compar-ison of endometrial cancer COX-2 expression was made within each group at different stages,for different pathological classification. Another groups comparison of COX-2 expression was made. Results ( 1 ) COX-2 in endometrial cancer in the different expression of other differences and differences were significant ( P<0.05 ). Ⅲ mainly for the period between the stage and the other had a significant difference( P<0.05 ). (2) COX-2 in endometrial cancer,hyperplasia and normal expression of the differences between endometriosis, the difference was significant ( P<0.05 ). (3)COX-2 in endometrium cancer different pathology graduation difference:G1(high idiophase) < G2(idiophase) < G3(low id-iophase), but does not have the difference after the comparison in statistics ( P>0.05 ). (4) The expression of COX-2 in simple hyperplasia and complex hyperplasia was statistically significant different ( P<0.05 ). Conclusion That COX-2 in the development of endometrial lesions play an important role, it could be inferred of COX-2 inhibitors for endometrial cancer treatment or treatment of postoperative the timing of the loss surgery patients is feasible.

The traditional medical treasures of zhouyi and qianjin have much in common in the aspects of logic approach,recognition characteristics,values conception,theory construction,and category system,which demonstrate that the two doctrines are closely related both geographically and historically. Bearing the same cultural genes and value orientation,sharing similar constructions of logic approaches and recognition characteristics,the two doctrines contain a great deal of wisdom in recognition and practice.

Objective To study the relationship between survival rate and pathogen,subtype,stage,delivered methods of 55 patients with severe hepatitis during late period of pregnancy.Methods Clinical data of 55 cases with severe hepatitis during late period of pregnancy was analyzed retrospectively.Results The incidence of hepatitis B was highest in patients with severe hepatitis during late period of pregnancy (84.5%).In subtypes,the incidence rates of chronic severe hepatitis,acute severe hepatitis and subacute severe hepatitis were 83.6%,5.5%,10.9% respectively(P

Objective To investigate the infection type,clinical features and prognosis in the infections complication patients with severe hepatitis.Methods 72 severe hepatitis patients with infections complication were analyzed retrospectively.Results The infection occurrence rate was 62.5% in the 72 severe hepatitis patients.Mortality rate was 75.56% in the patients with infections complication,and it was significantly higher than those without infections complication(29.63%).The mortality rate was 72.5% in the patients with multiple organ infections.The different bacterium infection could lead to different mortality rate,K.peneumoniae(69.89%),E.coli(58.12%),Staphylococcus aureaus(55.56%),Staphylococcus epidermidis(59.90%).The mortality rate was higher in the patients with lower sera albumin and higher serum bilirubin level.Conclusions The patients with severe hepatitis have bad outcome with infections complication.The prognosis is correlated with the dysfunction severity of liver and pathogenic bacteria.

Objective To investigate the role of TRAF2 in AP-1 signaling pathway of human B cells.Methods Human Ramos B cells were transfected with plasmids expressing YFP fusion wild type TRAF2(YFP-WT-TRAF2) or YFP fusion dominant-negative TRAF2(DN-TRAF2),or transfected with shRNA-TRAF2 and control shRNA plasmid.After incubation overnight,cells were either sorted with flowcytometry or screened by antibiotics G418.Activation of AP-1 pathway,including phosphorylation of ERK,JNK and P38,as well as nuclear translocation of AP-1 subunits were detected by western blot and ELISA.Results Overexpression of WT-TRAF2 selectively induced activition of MAPK by phosphorylation of ERK and P38,and further induced nuclear translocation of C-FOS.Moreover,both overexpression of DN-TRAF2 and transfection of shRNA-TRAF2 inhibited phosphorylation of ERK and P38,and nuclear translocation of C-FOS.Conclusion TRAF2 selectively activates some kinases in CD40 mediated AP-1 signaling pathway,and plays an important role in AP-1 activation.

AIM: To investigate the clinical effect of cataract combined lens dislocation greater than 2 quadrants` patients after having phase I intracapsular cataract extraction and anterior vitrectomy,postoperative corrected vision greater than 0.3,and then taking phase II small incision suture-fixation of intraocular lens suspension.METHODS: Totally 34 cases with cataract combined lens dislocation greater than 2 quadrants had been treated in our hospital from July 2014 to December 2016.We investigated their 1wk,1 and 3mo postoperative complications and the uncorrected visual acuity,best corrected visual acuity,intraocular pressure,corneal astigmatism who took phase II small incision suture-fixation of intraocular lens suspension with corrected vision greater than 0.3 after having phase I intracapsular cataract extraction and anterior vitrectomy.RESULTS: Along with the recovery time extension,patients` uncorrected visual acuity and best corrected visual acuity increased obviously than preoperative in each phase.On the 3mo postoperatively,the best corrected visual acuity of 1 eyes was between 0.3 and 0.1,8 eyes was between 0.5 and 0.3,16 eyes was between 0.7 and 0.5,and 9 eyes was better than 0.7.The best corrected visual acuity was achieved or near the best corrected visual acuity before surgery.Intraocular pressure rechecked became in the normal range at 1wk,1 and 3mo postoperative.Surgery did not significantly increase the corneal astigmatism.CONCLUSION: It is a safe and effective way in improving eyesight effectively,with stable intraocular pressure and fewer complications towards cataract combined lens dislocation greater than 2 quadrants` patients having phase I intracapsular cataract extraction and anterior vitrectomy,whose postoperative corrected vision greater than 0.3,and then phase II small incision suture-fixation of intraocular lens suspension.

Phellinus is a kind of rare medicinal fungus that has a variety of physiological activities include anti-cancer, anti-liver fibrosisa, antioxidant and so on. Phellinus contains polysaccharides, steroids, terpenoids, flavonoids, pyrone, furan, alkaloids and other substances. Polysaccharide extracts of phellinus showed obvious antitumor effect and has been a hot research field in recent years. It was also found other extracts of phellinus such as ethyl acetate extract exhibited anticancer activity. Thus, the antitumor effect of different extract, especially the anti-cancer mechanism were discussed in this review.
Antineoplastic Agents ; pharmacology ; Basidiomycota ; Cytokines ; analysis ; Neoplasm Metastasis ; prevention & control

Ten compounds, including five steroidal saponins and five flavonol glycosides, were isolated from the whole plant of Solanum coagulans by means of column chromatographies over silica gel, ODS, Sephadex LH-20, and preparative HPLC. Based on analysis of MS and NMR spectroscopic data, their structures were established as anguiviosides XV (1), smilaxchinoside A (2), methylprotodioscin (3), protodioscin (4), solamargine (5), 3', 4', 5-trihydroxy-7-methoxy-6-C-β-D-glucopyranoside (6), brainoside B (7), camsibriside A (8), kampferol 3-O-(2"-β-D-galactopyranosyl)-β-D-glucopyranoside (9), and quercetin-3-O-(2"-β-D-galactopyranosyl)-β-D-glucopyranoside (10). All the compounds were first isolated from this plant. In the in vitro assays, compounds 4 and 5 showed cytotoxic activity against SMCC-7721 and NCI-H460.
Cell Line, Tumor ; Flavonols ; chemistry ; isolation & purification ; pharmacology ; Humans ; Saponins ; chemistry ; isolation & purification ; pharmacology ; Solanum ; chemistry

Cervical Intraepithelial Neoplasia ; diagnosis ; epidemiology ; prevention & control ; virology ; China ; epidemiology ; Female ; Humans ; Mass Screening ; Nucleic Acid Hybridization ; methods ; Papillomaviridae ; isolation & purification ; Papillomavirus Infections ; diagnosis ; prevention & control ; Papillomavirus Vaccines ; Uterine Cervical Neoplasms ; diagnosis ; epidemiology ; prevention & control ; virology ; Vaginal Smears

Adult ; Bronchoalveolar Lavage ; Humans ; Male ; Middle Aged ; Pneumoconiosis ; complications ; therapy ; Pulmonary Disease, Chronic Obstructive ; etiology ; therapy ; Treatment Outcome