Objective To investigate the therapeutic effect of osteoporotic vertebral compression fractures treated by percutaneous kyphoplasty combined zoledronic acid.Methods Patients admitted to our hospital′s depart-ment of orthopedics from February 2010 to December 2013 were reviewed,and 67 patients underwent percutaneous ky-phoplasty were admitted.According to the application of zoledronic acid or not,they were divided into 2 groups,with 39 cases and 28 cases,respectively.On 67 patients before surgery,3 days after surgery,the end of follow -up surgery, VAS,ODI,vertebral height average recovery rate and Cobb angle were compared.The BMD was also compared before and after surgery.Results There was no difference between the two groups in all above indices before treatment(t =0.308,P =0.758;t =0.476,P =0.635;t =0.397,P =0.693;t =0.342,P =0.733).3 days after surgery,the levels of VAS,ODI and Cobb angle all decreased(t =25.820,P <0.001 vs.t =24.988,P <0.001;t =16.801,P <0.001 vs.t =17.008,P <0.001;t =9.717,P <0.001 vs.t =7.525,P <0.001),while vertebral height average recovery rate were increased in both groups(t =8.300,P <0.001 vs.t =6.363,P <0.001 ),but there was no difference between the two groups(t =0.177,P =0.861;t =0.568,P =0.572;t =0.453,P =0.652;t =0.508,P =0.613).In the end of follow -up surgery,there was a significant difference between the two groups(t =4.779,P <0.001;t =7.041,P <0.001;t =2.517,P =0.014;t =2.406,P =0.019).There was no difference between the two groups in BMD(t =0.479,P >0.05),but it came to be a difference between the two groups in the end(t =2.710,P =0.009), although there was no difference in secondary fracture(23.1% vs.7.1%,χ2 =3.016,P =0.082).Conclusion Per-cutaneous kyphoplasty combined zoledronic acid has an excellent effect on osteoporotic vertebral compression frac-tures,it is worthy promoting.

Recently the lysine succinylation was discovered in vivo, and it was demonstrated to be widely involved in cell dif-ferentiation, cell metabolism and other important physiological activities.Lysine succinylation has become the forefront of life science research.Scientists have provided a lot of evidences that proteins in prokaryotes and eukaryotes are widely succinylated, without which the central metabolism and intermediary metabolism of many metabolic enzymes are disrupted.To better understand the importance of Succinylation in vivo, protein-succinyl modification of the current research and the latest developments are reviewed, which summarize succinylated protein lysine sites in the center of important physiological metabolic pathways, diseases and other pathological conditions.

THe insulin-like growth factor(IGF) system,a very important polypeptide growth hormone,has been found to have some relation with primary adrenocortical tumorigenesis and modulates its growth.This article reviews the general biological characteristics of IGF and the relations of the IGF system with the normal adrenal cortex and primary adrenocortical tumor.It also and discuss the clinical meaning of its possible presence in the primary adrenocortical tumor.

Head and neck cancer presents with complex anatomy and high intratumoralheterogeneity. Radiotherapy is one of the main treatments. The therapeutic strategy and prognostic evaluation in head and neck cancer patients traditionally depend on TNM stage, lacking of individual information. Radiomics can extracts high-throughput image features relevant to the biology of tumors, which provides a non-invasive and quantitative method to evaluate the overall tumor heterogeneity and also offers a novel perspective for precision radiotherapy. The research progresses on the application and chanllenges of radiomics in the radiotherapy for head and neck cancer were summarized in this review.

Antimalarials ; therapeutic use ; Artemisinins ; therapeutic use ; Child ; Drug Therapy, Combination ; Humans ; Malaria, Falciparum ; drug therapy

Breast Neoplasms ; metabolism ; pathology ; surgery ; Carcinoma, Intraductal, Noninfiltrating ; metabolism ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; Lymphatic Metastasis ; Mastectomy ; methods ; Neoplasm Invasiveness ; Sentinel Lymph Node Biopsy ; Survival Rate

Based on collecting data at home and abroad, we combined clinical practice of scientific researches. We also summarized key points for design and evaluation of clinical studies in treating children's attention deficit hyperactivity disorder by Chinese medical new drugs from objective and design, selection of diagnostic criteria, recruitment and dropping-out of subjects, effectiveness evaluation, safety evaluation, drug combination, and quality control, and so on. We hope to provide reference for design and evaluation of clinical studies by Chinese medical new drugs.
Attention Deficit Disorder with Hyperactivity ; drug therapy ; Biomedical Research ; Child ; Clinical Studies as Topic ; Data Collection ; Drugs, Chinese Herbal ; therapeutic use ; Humans

Objective To investigate the correlation between lumbar curvature and lumbar intervertebral disc herniation.Methods 160 cases of young and mid-aged lumbar disc herniation patients were collected.All patients were divided into two groups accord-ing to the curvature.The age,sex,course of disease,occupation and MRI manifestations were recorded.Also,the recurrence and the arch top distance were recorded in 6 months after treatment.Results The age,sex,course of disease were similar between the two groups.70% of the patients in curvature straighten group were sitting or standing for long time in life,while in the other group more people were engaged in traditional manual work(P<0.05).The arch top distance increased in the curvature straighten group when rechecked(P<0.05).There were more patients with L4/L5 segment intervertebral disc herniation in the curvature straighten group,while more patients with L5/S1 segment intervertebral disc herniation in the other group(P<0.001).The recurrence rate was higher in the curvature straighten group,and the arch top distance was less in the patients with recurrence in both groups(P<0.05).Conclusion The patients with curvature straightening have a higher rate of recurrence and intervertebral disc herniation in L4/L5 segment.The recovery and reconstruction of the balance of the lumbar spine biomechanics is beneficial to the patients’cura-tive effect and functional recovery.

Aim To investigate the changes of phosphorylated p38 mitogen-activated protein kinase(p-p38MAPK)in the spinal cord following chronic compression of dorsal root ganglion(CCD)in rats, and to explore the correlation between chronic neuropathic pain and p38MAPK.Methods The animal model of neuropathic pain following chronic compression of dorsal root ganglion was established.36 male Sprague-Dawley rats were randomly divided into Naive group(n=4),Sham group(n=16),CCD group(n=16).Sham group and CCD group were also divided into 5,7,14 d and 21 d group respectively(n=4),Western blot analysis was used to investigate the expression of the phosphorylated active form of p38MAPK (p-p38MAPK) in the spinal dorsal horn in rats after CCD.Results p-p38MAPK protein was expressed in spinal cord among all three groups,but there were no significant differences between Naive group and Sham group.Compared to Naive and Sham group, rats in CCD group showed significant increase of the expression of p-p38MAPK protein in spinal cord.Compared with that of Sham group,protein expression of p-p38MAPK in cytosol in the spinal dorsal horn in 5,7,14 d and 21 d of post-surgery increased respectively 138.1%(P

Objective To investigate the expression of CD133 in human nasopharyngeal carcinoma cell line SUNE,and to detect proliferative and differential ability of CD133+ tumor cells in vitro,and to identify tumor-like stem cells in SUNE.Methods Immunocytochemical staining method and flow cytometry were used to detect the expression of putative tumor-initiated cell marker CD133 in nasopharyngeal carcinoma cell line SUNE,and the isolation technique with immunomagnetic beads was applied to purify CD133+ cells.The proliferative ability of CD133+ tumor cells in vitro was estimated by MTT assay,and the proliferative ability of CD133+,CD133-and control SUNE cells were statistically compared.Finally,the immunocytochemical staining method and flow cytometry were used to detect differential ability of CD133+ tumor cells in vitro.Results CD133 was positively expressed only in 0.35% of the cells in nasopharyngeal carcinoma cell line SUNE.In the serum-free medium RPM I1640,the UV optical density of the CD133+ tumor cells enriched with immunomagnetic beads was 0.317?0.007,0.370?0.002 and 0.558?0.004 at 3,5 and 7 days,respectively.Compared with CD133-cells and control SUNE cells,CD133+ cells showed increased proliferative capacity(P