1.Regulation effect of ORL1 and N/OFQ on central nervous system
Chinese Pharmacological Bulletin 2003;0(12):-
ORL1(Opioid receptor-like 1)receptor and its endogenous ligand,nociceptin/orphanin FQ,belong to G protein-coupled receptor super family with multiple functions.ORL1 is not only endowed with anti-opioid properties(it suppresses opioid-mediated analgesia),but also involved in cognitive processes,emotion,cardioprotection and neuroendocrine secretion.The research on ORL1 and N/OFQ will certainly be helpful to develop new therapeutic drugs and to find drug targets of clinical application.
2.Postoperative metabolic characteristics of islet transplantation in the treatment of type Ⅰ diabetes
Wu WEN ; Jiazhen GONG ; Qingmin MENG
Chinese Journal of General Surgery 1993;0(03):-
Objective To assess the effect of fetal islet transplantation for the treatment of Type Ⅰ diabetes. Methods The pancreatic islets from human aborted embryos were cultured and implanted into the greater omentum and omental bursa of 26 patients with type Ⅰ diabetes. The function of transplanted islets was evaluated. Results After transplantation, the exogenous insulin requirement significantly decreased (P
3.Risk Factors and Prevention of Ophthalmic Infection after Operation
Yuqin WEN ; Shan GONG ; Xin DONG
Chinese Journal of Nosocomiology 1994;0(04):-
OBJECTIVE To investigate the risk factors and prevent meaures of ophthalmic infection after operation. METHODS The factors associated with ophthalmic infection after operation were analyzed. The comprehensive and strict system of washing and sterilization of operative instruments were established. The usage of aseptic implantable articles was strictly managed. The management of operation environment,faculty,patients,and aseptic technique were further strengthened. The samples of the faculty were cultivated routinely and the fulfillment of institution was assured. RESULTS The procedure of peri-operation infection control was bettered. The awareness of infection prevention during ophthalmic operations was improved for the nurse faculty. A safe operation procedure was ascertained. The risk of ophthalmic operation infection was decreased. CONCLUSIONS Scientific and consummate management of ophthalmic operation and its proper fulfillment are key factors to prevent ophthalmic operation infection.
4.Curative effect and complication analysis of different shunt procedures for treatment of posttraumatic hydrocephalus
Jiangbiao GONG ; Liang WEN ; Xiaofeng YANG
Chinese Journal of Trauma 2016;32(2):105-109
Objective To compare the effect and complications of lumboperitoneal shunt (LP) and ventriculoperitoneal shunt (VP) in treatment of posttraumatic hydrocephalus (PTH).Methods A retrospective study was made on 150 cases of posttraumatic communicating hydrocephalus managed with LP or VP from June 2013 to June 2015.There were 65 cases [36 males, 29 females;(47.2 ±8.2) years of age] in LP group and 85 cases [53 males, 32 females;(44.6 ± 7.3) years of age] in VP group.Therapeutic effect and complications were analyzed postoperatively.Results Period of follow-up was 3-27 months, which shoued Total effective rate of 97% in LP group and 94% in VP group (P >0.05).Postoperative complications were mainly hematoma, infection, shunt obstruction, shunt exposure, excessive shunt and inadequate shunt.At the follow-up, there were 3 subdural hematoma, 4 intracranial infection, 2 shunt obstruction, 3 excessive shunt and 1 inadequate shunt in VP group, but 1 subdural hematoma, 1 intracranial infection, 1 shunt exposure and l excessive shunt in LP group.Good results were achieved in the two groups after regulation of the shunt pressure or reoperation.In comparison, incidence of complications was 6% in LP group versus 15% in VP group (P < 0.05).Rate of shunt removal and reoperation in LP group were both 2%, but were 7% and 8% respectively in VP group (P < 0.01).Conclusions Both shunt procedures are effective for posttraumatic hydrocephalus, while LP is a better choice in clinical application for the lower complication incidence, shunt removal rate and reoperation rate.
5.Surgical treatment of constipation
Xianghu ZHU ; Xuchen GONG ; Wen BAO
International Journal of Surgery 2008;35(7):492-494
To analyze the reasons for the formation of constipation,the causes,clinical manifestations,surgical indications and surgical treatment were analyzed,focusing on slow transit constipation,outlet obstruction constipation and mixed constipation.Grasping surgery indications is stressed in surgical treatment of constipation.Only appropriate procedure can obtain satisfactory results.
7.A new ent -kauranoid from rhizomes of Canna generalis
Acta Pharmaceutica Sinica 2022;57(5):1440-1443
Two
9.Alprostadil the pneumoconiosis rheology and respiratory function of patients with pulmonary heart disease clinical research.
Chui-yun LUI ; Xiang-wen GONG ; Qian CHEN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(9):694-696
Adult
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Aged
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Alprostadil
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therapeutic use
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Female
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Hemorheology
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Humans
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Male
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Middle Aged
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Pneumoconiosis
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blood
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drug therapy
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physiopathology
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Respiratory Function Tests
10.Clinical control study on Mirizzi syndrome treatment between laparoscopic operation and laparotomy
Jun GONG ; Xiaojiong YU ; Ke DONG ; Ergang WEN
Chinese Journal of Postgraduates of Medicine 2012;35(5):1-3
Objective To compare the advantages and disadvantages between laparoscopic operation and laparotomy in the treatment of Mirizzi syndrome.MethodsThe clinical data of 67 cases with Mirizzi syndrome were analyzed retrospectively from January 2008 to June 2011.Thirty-five cases were treated with laparoscopic operation(laparoscopic operation group),type Ⅰ in 24 cases,type Ⅱ in 11 cases,3 cases with conversion to laparotomy were rejected (type Ⅱ in 8 cases really).Thirty-five cases were treated with laparotomy(laparotomy group),type Ⅰ in 20 cases,type Ⅱ in 15 cases.The operation time,blood loss duringoperation,intake time of food,postoperative complications and hospital stay were compared between two groups.ResultsThe operation time was (53.2 ± 21.5) min,blood loss during operation was (23.2 ± 21.5)ml,intake time of food was 6 h,postoperative complications were with 3 cases (9.4%,3/32),hospital stay was(5.4 ±2.3) d in laparoscopic operation group.The operation time was(98.7 ± 17.2) min,blood loss during operation was ( 113.4 ± 31.6) ml,intake time of food was (46.8 ± 12.4) h,postoperative complications were with 5 cases( 14.3%,5/35 ),hospital stay was ( 11.3 ± 2.7) d in laparotomy group.Except for postoperative complications,there were significant differences in the operation time,blood loss during operation,intake time of food and hospital stay between two groups(P<0.05).ConclusionsLaparoscopic operation is safe and feasible in treating type Ⅰ and most type Ⅱ Mirizzi syndrome.It has more advantages than laparotomy.