2. The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction
Qian WANG ; Ying KONG ; Song LIN ; Ding-Yu WU ; Jian HU ; Lang HUANG ; Wen-Si ZANG ; Xiao-Wen LI ; Jian-Ming YANG ; Tian-Ming GAO
Neuroscience Bulletin 2021;37(9):1303-1313
Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced mood modification. Previous studies have found that astrocytes modulate depressive-like behaviors. Inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is the predominant isoform in mediating astrocyte Ca
3.The ATP Level in the mPFC Mediates the Antidepressant Effect of Calorie Restriction.
Qian WANG ; Ying KONG ; Song LIN ; Ding-Yu WU ; Jian HU ; Lang HUANG ; Wen-Si ZANG ; Xiao-Wen LI ; Jian-Ming YANG ; Tian-Ming GAO
Neuroscience Bulletin 2021;37(9):1303-1313
Food deprivation can rescue obesity and overweight-induced mood disorders, and promote mood performance in normal subjects. Animal studies and clinical research have revealed the antidepressant-like effect of calorie restriction, but little is known about the mechanism of calorie restriction-induced mood modification. Previous studies have found that astrocytes modulate depressive-like behaviors. Inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is the predominant isoform in mediating astrocyte Ca
Adenosine Triphosphate
;
Animals
;
Antidepressive Agents/therapeutic use*
;
Caloric Restriction
;
Mice
;
Mice, Knockout
;
Prefrontal Cortex