1.Imaging findings and clinical manifestations of pelvic lipomatosis:a report of 3 cases
Chao CHAI ; Qian JI ; Shuang XIA ; Lixiang HUANG ; Wen SHEN
Chinese Journal of General Practitioners 2014;(6):489-492
The imaging findings of pelvic lipomatosis as confirmed by operation and pathology were examined in 1 case and two follow-up asymptomatic cases retrospectively analyzed.The imaging findings included a compressed and deformed bladder with a superior displacement.Its shape was like an inverted tear and pear in coronal view and a banana in sagittal view.Bilateral ureters were both compressed with a medial deviation.And bilateral ureters were dilated with hydronephrosis in 1 case.Rectum and sigmoid were both compressed and became narrowed.The clinical manifestations included frequent urination , urgent urination , urination pain, dysuria, constipation, nausea, vomit and fever in 1 case while another 2 cases stayed asymptomatic.
2.Detection and Drug Resistance Analysis of Ureaplasma urealyticum and Mycoplasma hominis of Urogenital Tract
Yingming FEI ; Wen ZHAO ; Faxiang JIN ; Li HUANG ; Hua QIAN
Chinese Journal of Nosocomiology 2006;0(09):-
OBJECTIVE To find out the status about detection and drug resistance of Ureaplasma urealyticum(Uu) and Mycoplasma hominis(Mh) of urogenital tract infection in Shaoxing area of Zhejiang Province.METHODS The detections and drug sensitive tests of Uu and Mh adopting the reagent boxes produced by bioMerieux Company in France were made.RESULTS In 2678 samples of suspicious urogenital tract infection patients,980 samples cultured of mycoplasma were positive,and the positive rate was 36.6%.Among these cases,763 samples(28.5%) were Uu positive;116 samples(4.3%) were Mh positive.In the drug sensitive test,Uu and Mh were most sensitive to PRI,JOS,DOX and TET.To CFLX,OFL,ERY,CM and AM,they had the highest level of drug resistance.CONCLUSIONS The clinical therapy of mycoplasma infection ought to choose the appropriate antibiotics based on the results of the drug sensitive test of the laboratory.
3.Influence of nursing health education on morning blood pressure surge fluctuations in aged people with hypertension
Qian WEN ; Xue BAI ; Lingling HUANG ; Chunmei XU
Chinese Journal of cardiovascular Rehabilitation Medicine 2017;26(2):210-213
Objective: To explore influence of nursing health education on morning blood pressure surge (MBPS) fluctuations in aged patients with hypertension.Methods: A total of 100 outpatients and inpatients with non-dipper hypertension, who haven't been treated, were selected from Apr 2011 to Sep 2015.According to random number table method, patients were randomly and equally divided into routine treatment group and health education group (received nursing health education based on routine treatment group), both groups were treated for four weeks.MBPS, trough/peak(T/P) ratio and smoothness index (SI) were measured and compared between two groups after treatment.Results: Compared with routine treatment group after four-week treatment, there were significant reductions in systolic blood pressure (SBP) morning surge[(46.95±5.17) mmHg vs.(42.21±5.19) mmHg]and diastolic blood pressure (DBP) morning surge[(16.31±3.23) mmHg vs.(14.21±3.58) mmHg], and significant rise in SBP T/P[(59.22±6.65)% vs.(70.11±6.41)%], DBP T/P[(50.91±5.04)% vs.(56.97±5.12)%], SBP SI[(1.19±0.13) vs.(1.42±0.12)]and DBP SI[(1.11±0.09) vs.(1.29±0.08)]in health education group, P<0.05 all.Conclusion: Health education can effectively improve blood pressure fluctuations and may likely improve prognosis in patients with non-dipper hypertension, which is worth extending.
4.Blockade of retinal neovascularization by inhibiting erythropoietin in a mouse model
Wen-Zhi, HUANG ; Qian-Qing, LI ; Lu, WANG ; Wei, ZHANG
International Eye Science 2015;(4):605-607
AIM:To establish the murine model of oxygen induced retinopathy ( OIR) and to evaluate the inhibition of retinal neovascularization by erythropoietin ( EPO) blockade.
METHODS: Neonates of C57BL/6 mouse ( P7 ) were exposed to 75%±2% oxygen for 5d and return to normal air environment when 12d ( P12 ) to establish oxygen-induced retinal neovascularization model. The neonates were divided into groups, injected with 0. 5μL solution containing 25ng ( group A), 50ng ( group B), 250ng ( group C) of soluble erythropoietin receptor ( EPO-R) or PBS (group D) at P12, P14 and P16 in the right eye. On P17, the litters were sacrificed and their right eyes were enucleated and fixed with 4% paraformaldehyde, made pathological section. The number of breakthrough internal limiting membrane neovascular nuclei was counted with pathological retinal morphology, understanding theproliferative degree of retinal neovascularization.
RESULTS: The pathological sections showed the neovascular cell nuclei which penetrating the inner limiting membrane in intravitreal EPO receptor injection group was reduced statistically than that in PBS injection group, the difference was statistically significant ( P<0.01). And, neovascular nuclei count differences in the
various concentrations of EPO receptor group was statistically significant (P<0. 01). With the EPO receptor concentration increase, neovascular endothelial cells broken through the internal limiting membrane was reduced.
CONCLUSION: Intravitreal injection of soluble EPO receptor can block EPO and improve neovascularization. The new method is expected to become new treatment of ocular neovascular diseases.
5.Not Available.
Yi wen HUANG ; Jie ZHANG ; Jun XU ; Yu qian WANG
Journal of Forensic Medicine 2022;38(4):538-544
6.Aterial Spin Labeling Evaluation of Residual Renal Function After Partial Nephrectomy on Renal Cell Carcinoma
Chenglong WEN ; Tao REN ; Lihua CHEN ; Lixiang HUANG ; Shuangshuang XIE ; Chao CHAI ; Qian LIU ; Wen SHEN
Chinese Journal of Medical Imaging 2017;25(7):555-558
Purpose To investigate the value of arterial spin labeling (ASL) in evaluating renal function in patients with renal cell carcinoma (RCC) after laparoscopic partial nephrectomy.Materials and Methods Fifteen patients with RCC undergoing laparoscopic partial nephrectomy were studied prospectively.The patients were performed ASL scan one week before and three months after operation.The correlation between renal blood flow (RBF) value measured by ASL and the glomerular filtration rate (GFR) measured by radionuclide method in the renal cortex of healthy side was analyzed.The RBF values in the kidney of affected side or healthy side were measured,the difference of which between before operation and three months after operation was compared.Results The RBF value and GFR data in the renal cortex of healthy side had positive correlation (r=0.638,P<0.05).In the affected side of kidney,the RBF value of remaining renal tissue [(291.5 ± 37.3) ml/(100g·min)] compared with that of preoperative renal tissue [(237.8 ± 46.2) ml/(100g·min)]increased about 53.7 ml/(100g · min) (P<0.05).In the healthy side of kidney,the RBF value of renal tissue [(241.1 ± 50.3) ml/(100 g · min)] compared with that of preoperative renal tissue [(290.4 ± 51.8) ml/(100 g·min)] decreased about 49.3 ml/(100 g·min) (P<0.05).Conclusion ASL can be used to evaluate renal function,and it is valuable to evaluate renal perfusion function after laparoscopic partial nephrectomy of RCC.
7.Changes of serum albumin and globulin levels and albumin-globulin ratio in patients with cerebral infarction
Chinese Journal of Neuromedicine 2011;10(10):1023-1026
Objective To explore the changes of serum albumin and globulin levels andalbumin-globulin ratio in patients with cerebral infarction,and their prognostic value.Methods Onehundred and twenty patients with acute ischemic stroke,admitted to our hospital from June 2006 to June2010,were chosen as Group Ⅰ; Group Ⅱ included 110 subjects matched with Group Ⅰ for age,medications,and clinical risk factors of stroke; and Group Ⅲ was composed of 90 healthy volunteers,matched for agewith Group Ⅰ and Ⅱ.Serum albumin and globulin levels,albumin-globulin ratio,fibrinogen level andnumber of peripheral blood cells in the 3 groups were compared; and the prognosis of subjects with analbumin-globulin ratio above 1.45 or less were compared between each 2 groups after 2-year-follow-up.Results Serum globulin,fibrinogen and leucocyte levels in Group Ⅰ were significantly higher than thosein Group Ⅱ and Ⅲ,and those in Group Ⅱ were obviously higher than those in Group Ⅲ (P<0.05).Serumalbumin level and albumin-globulin ratio in Group Ⅰ were significantly lower than those in Group ⅡⅡ andⅢ,and those in Group Ⅱ were obviously lower than those in Group Ⅲ (P<0.05).To the end of follow-up,the incidence of recurrent cerebrovascular disease were 24.1%,18.5% and 2.3% in Group Ⅰ,Ⅱ and Ⅲ,respectively(P<0.05).Subjects with albumin-globulin ratio less than 1.45 in Group Ⅰ and Ⅱ had 3.6 timesof risk for a subsequent vascular event as compared with their counterparts with albumin-globulin ratioabove 1.45.Conclusion Serum albumin and globulin levels and albumin-globulin ratio have a closecorrelation with cerebral infarction.The patients with low albumin-globulin ratio have increased risk ofcerebrovascular disease as compared with subjects of normal albumin-globulin ratio in subjects with cerebral infarction and high-risk cerebrovascular disease.
8.A new flavonoid glycoside from leaves of Eucalyptus robusta.
Xi-feng GUAN ; Qian-yi GUO ; Xiao-jun HUANG ; Ying WANG ; Wen-cai YE
China Journal of Chinese Materia Medica 2015;40(24):4868-4872
A new flavonoid glycoside, (-)-2S-8-methyl-5,7,4'-trihydroxyflavanone-7-O-β-D-glucopyranoside (1), along with five known ones, quercetin-3-O-(2"-galloyl)-α-L-arabinoside (2), kaempferol-3-O-α-L-arabinoside (3), guaijaverin (4), trifolin (5) and hyperin (6), was isolated from the leaves of Eucalyptus robusta. Their structures with absolute configurations were elucidated by NMR, HR-ESI-MS, CD spectra data and physicochemical methods. In addition, 2-6 were isolated from E. robusta for the first time.
Eucalyptus
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chemistry
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Flavonoids
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chemistry
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isolation & purification
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Glycosides
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chemistry
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isolation & purification
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Plant Leaves
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chemistry
9.Questionnaire survey on obstructive sleep apnea hypoventilation syndrome and related complications
Qian CAI ; Weiping WEN ; Zhenzhong SU ; Weichi GONG ; Hua ZOU ; Zhibin HUANG
Chinese Journal of General Practitioners 2011;10(2):90-92
Objective To investigate relationship between obstructive sleep apnea hypoventilation syndrome(OSAHS) and hypertension.Methods Questionnaire survey was conducted among 1573 local permanent residents in Guangzhou during March and June 2006 to understand prevalence of hypertension and snoring,and polysomnography monitoring was performed for 347 of them with moderate and severe snoring to estimate prevalence of OSAHS.Risk factors for hypertension was screened with multivariate logistic regression analysis.Results In total,1547 copies of valid questionnaires were collected,and 184 cases (11.9%) of hypertension were found with a prevalence of 10Department of Endocrinology,Shanxi Provincial People's Hospital,Taiyuan 030012,China 0%,49 of diabetes with a prevalence of 2.7%,and 212 of dyslipidemia with a prevalence of 10.4%.Prevalence of OSAHS was found in 34 of them (2.2% ) with Epworth sleepiness scale (ESS) score equal to or greater than nine.Prevalence of hypertension in OSAHS group was 32.5%,much higher than that in non-snoring group (8.3% ) and snoring group ( 17.1% ).Results of logistic regression analysis showed that age,gender,OSAHS,diabetes and dyslipidemia all were high-risk factors for hypertension,with OSAHS ranking the third.Conclusion OSAHS is one of high-risk factors for hypertension.
10.Development of a scoring system to evaluate peptic ulcer risks
Xiaozhen TIAN ; Wei QIAN ; Yongzhen ZHANG ; Fan YANG ; Wen HUANG ; Zhaoshen LI ; Quancai CAI
Chinese Journal of Digestive Endoscopy 2016;33(5):316-320
Objective To develop a scoring system to determine peptic ulcer risks and to evaluate its screening efficiency.Methods A total of 862 people who underwent gastroscopy for the first time ranging from 18 to 45 years old were enrolled in this study.They were divided into two cohorts with the method of simple random sampling,514 in the original cohort and 348 in the validation cohort.Information such as demographic characteristics,dietary intake,lifestyle,symptoms relating to peptic ulcer was obtained.A multivariable logistic regression method was used to determine independent predictors of peptic ulcer.Based on the logistic regression model,a scoring system was developed with a regression coefficient-based scoring method.Then the scoring system was internally and externally validated.Each value of calibration,discrimination and accuracy were computed and then compared with those of original cohort to assess its screening efficiency.Results Three variables (gender,smoking and melena) composed the scoring system with scores ranging from 0 to 4 points.It had good calibration (P =0.956) and discrimination (area under the ROC =0.70,95%CI:0.65-0.76).With 2.5 points as the screening cutoff value,the sensitivity,specificity,accuracy rate,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 49.5%,82.2%,75.5%,41.6%,86.4%,2.78 and 0.61,respectively.In the validation cohort,the sensitivity,specificity,accuracy rate,positive predictive value,negative predictive value,positive likelihood ratio and negative likelihood ratio were 27.2%,92.7%,71.3%,64.6%,72.3%,3.89 and 0.79.The results above indicated that the screening efficiency of the scoring system in the original cohort was similar to that in the validation cohort.Conclusion The scoring system to determine peptic ulcer risks,containing gender,smoking and melena,has good screening efficiency and can be applied to predict the risks of peptic ulcer.