2.Effect of Valproate on Leptin and Serum Lipids in Children with Epilepsy
zhao-chun, WEN ; ru-ming, WANG
Journal of Applied Clinical Pediatrics 2004;0(12):-
Objective To explore the effect of valproate(VPA) on body mass index(BMI),leptin and serum lipids in children with epilepsy.Methods (Twenty-)four cases with epilepsy were selected.BMI and serum levels of leptin,total cholesterol(TC),(triacylgly)-cerol(TG),high density lipoprotein-cholesterin(HDL-C),low density hipoprotein-cholesterin(LDL-C) after treated with VPA for 3 months and 6 months were determined.Results The levels of BMI,leptin,TC,TG,LDL-C after treated 3 months were all significantly higher than those of initial(all P0.05).Those in treated 6 months were same as levels of treated 3 months.Only LDL-C level was lower than that of 3 months and same as level of before treatment.Conclusion VPA do have efficacy to cause obesity in children with epilepsy,and most of the cases occur in the first 3 months after VPA treatment.
3.Investigation of expression of c-erbB-2 and DPC4 in tissues of colonic schistosomiasis and colorectal carcinoma
Kuangsong WANG ; Jifang WEN ; Ming SHEN
Chinese Journal of General Surgery 1993;0(03):-
Objective To determine the relationship between chronic colonic schistosomiasis and colorectal carcinoma.Methods Expression levels of c-erbB-2 and DPC4 were detected by two-step and SP immunohistochemical method respectively in normal colonic mucosa of 15 cases,in colonic mucosa of 15 cases with simple schistosomiasis,20 cases of colorectal carcinoma with schistosomiasis and 20 cases of colorectal carcinoma without schistosomiasis.Results c-erbB-2 was expressed in each group with different levels,but the level in colonic mucosa with schistosomiasis was the highest compared to other groups,which had statistical significance(P
4.Risk factors for recurrence of ovarian endometriomas after surgical excision.
Ming, YUAN ; Wen-wen, WANG ; Yan, LI ; Ling, GAO ; Tian, WANG ; Shi-xuan, WANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2014;34(2):213-9
Ovarian endometrioma is a common form of endometriosis, which may cause infertility, dysmenorrhea and pelvic pain in women of reproductive age. Although surgery is the treatment of choice for endometriomas, recurrence poses a formidable frustration. This study investigated potential risk factors of endometriomas recurrence, aiming to better understand its pathogenesis. A total of 307 patients with endometriomas were followed up for an average of 28.6 months and the 1-, 2- and 3-year cumulative recurrence rate was 9.5%, 21.9%, and 29.2%, respectively. Twenty-one potential risk factors for endometriomas recurrence were evaluated using Cox's proportional hazards models. Total revised American Fertility Society (rAFS) score was significantly associated with higher recurrence (OR=1.858, 95% CI=1.122-3.075, P=0.016), as well as younger age at surgery (OR=0.953, 95% CI=0.915-0.992, P=0.020). Semiradical surgical treatment was defined as surgical removal of cyst plus hysterectomy with preservation of bilateral or unilateral ovary, and was a significant factor that was associated with lower recurrence than the conservative surgery (OR=0.318, 95% CI=0.107-0.951, P=0.040). Postoperative pregnancy was favorable factors for disease recurrence (OR=0.217, 95% CI=0.102-0.460, P=0.000). The results suggest that endometrioma recurrence is inversely associated with age at surgery and postoperative pregnancy, and may correlate with total rAFS score and conservative surgery method.
6.Injury of hepatic mitochondria and its mechanism in rats with endotoxemia.
Ming-Hua BI ; Shu-Wen ZHANG ; Ban-En WANG
Chinese Journal of Applied Physiology 2004;20(1):90-97
Animals
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Endotoxemia
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metabolism
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pathology
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Female
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Liver
;
metabolism
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pathology
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Male
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Mitochondria, Liver
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metabolism
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Rats
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Reactive Oxygen Species
;
metabolism
8.Related factors of death in patients with gas burst induced burn.
Lin-hong LIU ; Wen-jie REN ; Ming-jun WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(10):611-613
Adult
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Burns
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etiology
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mortality
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China
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epidemiology
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Coal Mining
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Explosions
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Female
;
Gases
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Humans
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Male
;
Middle Aged
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Retrospective Studies
;
Young Adult
9.Literature review on premarketing and postmarketing evidence of xiyanping injection.
Zhi-Fei WANG ; Xiao CHEN ; Wen ZHANG ; Yan-Ming XIE
China Journal of Chinese Materia Medica 2014;39(18):3637-3640
This article systematically summarizes the non-clinical safety studies, pharmacological studies and postmarketing safety studies of Xiyanping injection based on literature. These studies include acute toxicity test, long-term toxicity test, reproductive toxicity test, active and passive anaphylaxis test, curative mechanism study, clinical trials of effectiveness, active surveillance, security analysis of passive monitoring data, the real world analysis of hospital information system (HIS) data, literature analysis, etcetera This article also analysis the relationship of the different evidence, summarizes the strategy of the researches, in order to make it to be a reference for making a systemic research program of traditional Chinese medicine injection.
Drugs, Chinese Herbal
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administration & dosage
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adverse effects
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Injections
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Medicine, Chinese Traditional
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methods
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Product Surveillance, Postmarketing
10.Clinical analysis of 221 cases of inhalation injury induced by gas explosion.
Lin-hong LIU ; Wen-jie REN ; Ming-jun WANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2007;25(8):494-495
Adolescent
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Adult
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Burns, Inhalation
;
etiology
;
therapy
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Explosions
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Female
;
Gases
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Humans
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Male
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Retrospective Studies
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Young Adult