Alzheimer Disease ; metabolism ; Animals ; Brain ; metabolism ; Calcium-Binding Proteins ; biosynthesis ; chemistry ; genetics ; Gastrointestinal Tract ; metabolism ; Humans ; Islets of Langerhans ; metabolism ; Neoplasms ; metabolism ; RNA, Messenger ; metabolism ; Secretagogins ; Thyroid Gland ; metabolism

Objective: To investigate the risk factors for hemorrhagic transformation (HT) in patients with cerebral infarction. Methods: The clinical data of 960 patients with cerebral infarction admitted to the Department of Neurology, Hangzhou First People's Hospital Affiliated to Nanjing Medical University were analyzed retrospectively. They were divided into HT group (n =90) and non-HT group (n =870) according to whether they had HT or not. The blood pressure, postprandial and fasting blood glucose, cholesterol levels, infarct size detected by imaging, atrial fibrillation and thrombolysis within 24 hours of admission, anticoagulant therapy before or after admission, previous history of anti-platelet aggregation therapy and TOAST classification in both groups were observed. The risk factors for HT were identified by univariate chi-square test and multivariate logistic regression analysis, and the incidences of HT in various types of cerebral infarction in the TOAST classification were compared. Results: Circled digit oneThe results of multivariate logistic regression analysis showed that massive cerebral infarction (P = 0.000, OR = 10. 519, 95% CI 6. 600-16. 766), atrial fibrillation (P = 0. 006, OR = 1. 913, 95% CI 1. 206-3. 003), thrombolysis (P = 0. 033, OR= 2. 502, 95%CI 1.078-5.805), anticoagulation (P = 0. 000, OR = 7. 877, 95% CI 2. 491-25. 911), and postprandial glucose ≥10 mmol/L or fasting glucose ≥7. 0 mmol/L (P = 0. 011, OR = 0. 822, 95% CI 1. 146-2.897) were the independent risk factors for HT. Systolic blood pressure ≥ 180 mm Hg and/or diastolic blood pressure ≥ 110 mm Hg, high cholesterol (≥ 5. 98 mmol/L) , and the history of anti-platelet aggregation were not the independent risk factors for HT. Circled digit twoIn the TOAST classification, the HT incidence in patients with cardioembolic cerebral infarction was the highest (21. 4% , 34/159), the HT incidence of small artery occlusion was lower (1. 1%, 2/181 ), and the HT incidence of large artery atherosclerosis was 8. 6% (51/593). Conclusion: Massive cerebral infarction, atrial fibrillation, thrombolysis, anticoagulation, postprandial glucose ≥ 10 mmol/L or fasting glucose ≥ 7. 0 mmol/L are the independent risk factors for HT. Cardioembolic cerebral infarction is one of the major reasons for the occurrence of HT.

Cell Line, Tumor ; Humans ; Leukemia-Lymphoma, Adult T-Cell ; metabolism ; NF-kappa B ; metabolism ; Proto-Oncogene Proteins ; metabolism ; Transcription Factors ; metabolism

China ; Health Surveys ; Humans ; Physical Fitness ; Students

Exhaled gaseous signal molecules such as nitric oxide(NO),carbon monoxide(CO) and hydrogen sulfide(H2S) can be measured with a non-invasive technique.The fraction of NO level in exhaled gaseous of patients with airway inflammatory illness(such as bronchial asthma) significantly increases.No in exhaled gaseous is one of the markers in the diagnosis of asthma,and it is also a marker of anti-inflammatory response for patients with asthma.The fraction of CO level in exhaled gaseous of patients with bronchial asthma is also si-gnificantly elevated.Both NO and CO in exhaled gaseous in other airway inflammatory illness,such as chronic obstructive pulmonary disease,chronic bronchitis and cystic fibrosis are also evidently changed.Measuring exhaled gaseous signal molecules can provide important basis for the diagnosis and treatment of airway inflammatory illness.

AlM: To evaluate the clinical efficacy of canalicular intubation combined with external dacryocystorhinostomy ( ext-DCR ) for treatment of chronic dacryocystitis and upper lacrimal duct stenosis.
METHODS:Thirty-three patients (33 eyes) with chronic dacryocystitis and upper lacrimal duct stenosis who underwent canalicular intubation combined ext-DCR were retrospective analyzed. The silicon tube was indwelt for 6mo. All cases were re-examined 1wk;1, 3, 6, 9mo post-operation, flow of tears, pus excretion and lacrimal duct clearance were observed.
RESULTS: Clear lacrimal duct ratio was 100% in all cases during 1wk~6mo post-operation; Silicon tube was removed 6mo post-operation, 3mo after tube removal, rechecking reported 32 cases with clear lacrimal duct (97%) and 1 case with resistant duct (3%). Two cases ( 6%) with minor lacerations, no other complications were observed.
CONCLUSlON: Canalicular intubation combined ext-DCR is an effective treatment for chronic dacryocystitis and upper lacrimal duct stenosis.

Objective: The ultra performance liquid chromatography diode array detection method was used to establish the determination methods for the contents of procyanidin B1, procyanidin B2, procyanidin B4, rutin, and quercetin in Aronia melanocarpa berry. Methods: Waters Acquity UPLC® HSS T3 C18 column (100 mm × 2.1 mm, 1.8 μm) was used. The mobile phase was methanol (A)-0.03% phosphoric acid in water (B) for the gradient elution with flow rate of 0.2 mL/min. The column temperature was 35℃. The determination wavelength for procyanidin B1, procyanidin B2 and procyanidin B4 was 280 nm, and that for rutin and quercetin was 360 nm. Results: There was a linear correlation between the concentration of procyanidin B1 2.2-44.0 μg/mL (r = 0.999 2), procyanidin B2 50-1 000 μg/mL (r = 0.999 5), procyanidin B4 3.6-54.0 μg/mL (r = 0.999 2), rutin 7.4-148.0 μg/mL (r = 0.999 4), and quercetin 2.1-42.0 μg/mL (r = 0.999 7). The average recovery rates of procyanidin B1, procyanidin B2, procyanidin B4, rutin, and quercetin were 101.23% (RSD = 2.13%), 99.64% (RSD = 1.23%), 102.31% (RSD = 2.89%), 98.74% (RSD = 2.96%), and 103.53% (RSD = 2.64%), respectively. The average contents of procyanidin B1, procyanidin B2, procyanidin B4, rutin, and quercetin in Aronia melanocarpa berry were 129.78, 3 834.99, 196.02, 134.40 and 79.10 μg/g, respectively. Conclusion: The analysis method is simple, rapid, reproducible, accurate, and reliable, and can be used to identify and evaluate the quantitative determination of five constituents in A. melanocarpa berry.

China ; Cohort Studies ; Health Surveys ; Humans ; Nutrition Surveys

?AIM: To compare postoperative anti -inflammation effect and safety between bromfenac sodium eye drops and pranoprofen eye drops in patients after laser epithelial keratomileusis ( LASEK) .? METHODS: In the prospective, randomized and controlled study, 100 patients ( 200 eyes ) undergoing LASEK were randomized into the bromfenac sodium group (100 eyes) and control group (100 eyes).Patients in bromfenac sodium group received bromfenac sodium hydrate ophthalmic solution eye drops twice a day in 3d before surgery and 2wk after surgery, while the patients from the control group were given proanoprofen eye drops 4 times a day in the same period.At 1, 3, 5d, 1 and 3mo after surgery, irritative symptoms grade, duration of irritation, time for corneal epithelial healing, cornel haze, uncorrected visual acuity and intraocular pressure ( IOP ) were observed and compared between the two groups. Quantitative data were analyzed using independent samples t-test and ranked data were statistically analyzed using the Mann-Whiteney rank sun test.?RESULTS:There was no significant difference between two groups in irritative symptoms grade ( P =0.317 ), neither was existed between two groups in uncorrected visual acuity after surgery (P>0.05).There was no statistical significance in the time for corneal epithelial healing between two groups (P=0.551).?CONCLUSION: Bromfenac sodium eye drops ( 1g/L ) can achieve the same therapeutic effect as pranoprofen eye drops after LASEK.

Objective To evaluate the efficacy and clinical feasibility of the computer-assisted full plan- ning system for tibial fracture treatment with intramedullary nailing.Methods After analyzing the functional structure and operative procedures of the system,nine plastic tibia and 12 cadaver lower limbs were used for image mosaicing based on C-arm (PHILIPS BV Libra) fluoroscopic images in the operation room to assess the correctness of the mosaicing and planning algorithms.The plastic tibial model was used for analysis of the mosaicing precision.The cadaver tibial bone was used for reduction experiment with the reduction mechanism to analyze the operation feasi- bility.Results Only 7 to 10 [fluoroscopy time:(19.75?0.61)s] valid C-ann projection images were needed to produce a long bone panorama of the lower limb.The total time for image acquisition and mosaicing was within (4.17?0.86)minutes and the mosaicing precision in the plastic tibial model was (1.26?0.76)mm.The opera- tion of the reduction mechanism was very simple and could be controlled by a surgeon automatically or free of hand. An integrated reduction strategy could be produced for rough positioning in general and elaborate operations in de- tails.Conclusion The computer-assisted full planning system can be used for anatomical analysis based on the C-arm panorama,full surgical planning,virtual simulation,selection of proper intramedullary nails and fracture reduction in treatment of long bone fractures.