Aged ; Case-Control Studies ; Humans ; Male ; Malondialdehyde ; metabolism ; Middle Aged ; Oxidation-Reduction ; Serum ; metabolism ; Silicosis ; blood ; Superoxide Dismutase ; metabolism

Animals ; Extinction, Psychological ; physiology ; Fear ; physiology ; Male ; Mental Recall ; physiology ; Rats ; Rats, Sprague-Dawley ; Sleep Deprivation ; complications ; physiopathology ; Sleep, REM ; physiology

Aged ; Air Pollutants, Occupational ; Eosinophil Cationic Protein ; blood ; Humans ; Immunoglobulin E ; blood ; Inhalation Exposure ; Male ; Middle Aged ; Silicosis ; blood

Based on signal to noise ratio and probabilistic neural network method associated with experimental data,all analysis model in gastric carcinoma is presented.According to the available information,the samples of gastric carcinoma can be tested and ana.Lyzed.The signal to noise ratio is first calculated．Secondly,records in the database are chosen as a training set to build a probabilistie neural network model and the feature subset is selected according to accuracy.Finally,test set is to test accuracy of model．The model is implemented using MATLAB,and it can be generalized and applied to similar disease auxiliary diagnosis region.

Objective:To provide some thoughts for pharmaceutical treatment and care for the patients with pulmonary infection af-ter renal transplantation. Methods:Clinical pharmacists participated the whole treatment process of one case of pulmonary infection af-ter renal transplantation. According to the literatures combined with medical history, clinical symptoms and lab results, the drug treat-ment process of the patient was analyzed, and the key points of the optimized pharmaceutical care were summarized. Results: The pharmaceutical care included the dose adjustment of immunosuppressants at the early phase of the disease and after the improvement of clinical symptoms, attention paid to the interactions between multiple anti-infective drugs and immunosuppressive agents, dosage ad-justment based on the renal function of the patient, monitoring adverse drug reactions and drawing up personalized regimen. Conclu-sion:Through comprehensive medication monitoring, clinical pharmacists can help physicians develop timely and effective treatment programs and provide professional and effective pharmaceutical care for patients.

Objective To study the middle ear damage caused by high pressure.Methods The finite element model of human middle ear was established based on CT scanning,and the change of stress,strain and displacement of the tympanic membrane and stapes footplate was analyzed when the model was applied with timevarying pressure.Results The satisfactory agreement between the computational results and the corresponding experimental data in the literature could indicate the validity of the model.High pressure would cause damage to middle ear,and the damage would be aggravated with the pressure increasing.Rapid pressurization could make severely damage to middle ear,but have minor effect on inner ear.Slow pressurization could also lead to middle ear damage,but inner ear might be damaged before the injury to middle ear.Conclusions High pressure can easily lead to the ear damage;therefore,the pressurized rate should be controlled strictly to protect the hearing during pressurization.

Objective To evaluate the clinical outcome and relative factors of intervention treatment for atherosclerotic renal artery stenosis in elderly patients.Methods The clinical data of 79 patients diagnosed as atherosclerotic renal artery stenosis by angiography and treated by revascularization were analyzed.Results There were 55(69.6%)successes and 24(30.4%)failures in decreasing blood pressure and 28(35.4%)successes and 51(64.6%)failures in improving renal function after intervention treatment.Predictors of favorable outcome of intervention treatment in decreasing blood pressure were related to lower urine protein,higher glomerular filtration rate,higher systolic and diastolic blood pressure before treatment,lower resistance index(RI)of renal artery,and no complication of cerebral vascular diseases.Predictors of favorable outcome of intervention treatment in improving renal function were related with percentage of angiographic stenosis,category of antihypertension and lower urine protein.The logistic regression analysis showed that the percentage of angiographic stenosis was the most important predictor of intervention treatment for blood pressure control,age and level of serum creatinine before intervention treatment were the most important predictors of intervention treatment for improving renal faction.Conclusion Percentage of stenosis(≥85%),age(133 ?mol/L)can be used as the predictors of therapeutic success for renovascular stenosis in older patients.

Objective To study the middle ear damage caused by high pressure. Methods The finite element model of human middle ear was established based on CT scanning, and the change of stress, strain and displacement of the tympanic membrane and the stapes footplate was analyzed when the model was applied with time-varying pressure. Results The satisfactory agreement between the computational results and the corresponding experimental data in the literature indicated the validity of the model. High pressure would cause damage to the middle ear, and the damage would increase with the pressure increasing. Rapid pressurization could severely damage the middle ear, but with a small effect on the inner ear. Slow pressurization could also lead to the middle ear damage, but the inner ear might be damaged before the damage to the middle ear. Conclusions High pressure can easily lead to the ear damage; therefore, the pressurized rate should be controlled strictly during pressurization in order to protect the hearing.

Objective To obtain elastic modulus through displacement of the ear structure. Methods The finite element model (FEM) of human ear structure based on Patran software was constructed and the neural network for inverse derivative of elastic modulus for the ear was established using Matlab software. The frequency response of the ear structure FEM was calculated to obtain the displacements of tympanic membrane and stapes. The displacements acting as input data of training samples and the corresponding elastic modulus acting as output data were used to train the neural network. Results The elastic modulus was inversely derived by adopting this mature neural network with relatively less error. Conclusions The viability of the proposed methods for inverse derivative of elastic modulus was demonstrated in this paper, which could provide a simple and effective method to obtain mechanical parameters for clinic work.

Objective To investigate the occurrence of viremia in infants with rotavirus diarrhea. Method The rotavirus ge- nome in the plasma samples of 60 infants with rotavirus diarrhea and in the peripherial blood mononuclear cells (PBMCs) of 14 out of the infants who showed abnormal serum enzyme levels were subjected to nest reverse transcriptase polymerase chain reaction test. Results One infant was found to be positive for rotavirus in the plasma and 3 in the mononuclear cells, and the latter 3 infants was negative for rotavirus in the PBMCs. Conclusion Rotavirus viremia may occur in infants with rotavirus diarrhea.