1.Injury of hepatic mitochondria and its mechanism in rats with endotoxemia.
Ming-Hua BI ; Shu-Wen ZHANG ; Ban-En WANG
Chinese Journal of Applied Physiology 2004;20(1):90-97
Animals
;
Endotoxemia
;
metabolism
;
pathology
;
Female
;
Liver
;
metabolism
;
pathology
;
Male
;
Mitochondria, Liver
;
metabolism
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Rats
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Reactive Oxygen Species
;
metabolism
2.Relationship of urine cobalt and individual exposure levels of cobalt and its compounds in cobalt exposed workers
LUO Xiao ting CHEN Wen DONG Ming WU Chuan LIN Zuo kan TAN Jian ming WU Bang hua
China Occupational Medicine 2022;49(06):615-620
Objective -
To analyze the relationship between cobalt level of post shift urine and individual exposure level of
,
cobalt and its compounds in cobalt exposed workers and to explore the feasibility of using urine cobalt as a biomarker.
Methods -
A total of 148 occupational cobalt exposed workers from a new material company were selected as the exposed
, - -
group and 44 non occupational cobalt exposed workers from the company were selected as the control group using the typical
sampling method. The exposure concentration of time weighted average of cobalt and its compounds in the workplace air of the
-
two groups was determined by inductively coupled plasma mass spectrometry as the individual exposure level. The cobalt levels
- -
of pre shift and post shift urinary samples of the two groups were detected by this method. The linear relationship between the
-
cobalt level of post shift urine and the individual exposure level of cobalt and its compounds in the air of the workplace was
Results - 3
analyzed. The individual exposure level of cobalt and its compounds in the exposed group was 1.10 131.71 μg/m with
(M) 3
the median of 12.23 μg/m. No cobalt and its compounds were detected in the workplace air in the control group. The cobalt
- -
levels of pre shift and post shift urines in exposed group were higher than those in the control group at the same time point
(M: vs , vs , P ) - -
1.54 0.56 μg/L 8.77 0.83 μg/L all <0.01 . The cobalt level of post shift urine was higher than that in pre shift
(M: vs ,P ),
urine in the exposed group 8.77 1.54 μg/L <0.01 and it was positively correlated with the individual exposure level
( ,P ) ,
of cobalt and its compounds Spearman correlation coefficient=0.86 <0.01 . After common logarithm conversion the linear regression equation of the cobalt level of post shift urine and the common logarithm of individual exposure level of cobalt and
(x) :ŷ x( ;F ,
its compounds in the exposed group was as follows = −0.178 + 0.988 coefficient of determination=0.72 =374.75
P ;t , P ) Conclusion -
<0.01 = - 19.36 <0.01 . There was a linear correlation between cobalt level of post shift urine and
occupational cobalt exposure level of cobalt exposed workers. Urinary cobalt can be used as a biomarker of occupational cobalt
3.Clinical safety studies based on 30 026 post-marketing cases of Shenqi Fuzheng injection by intensive hospital monitoring nested NCCS.
Lian-xin WANG ; Yan-ming XIE ; Qing-hua AI ; Wen-fu XU
China Journal of Chinese Materia Medica 2015;40(24):4739-4745
This study adopted a large sample, multicenter, registered hospital centralized monitoring nested prospective case-control study design. From the real world clinical application of Shenqi Fuzheng injection, monitored 30 026 cases of patients with the use of Shenqi Fuzheng injection. A total of 51 adverse drug reaction (ADR) cases was monitored, including 1 case of severe adverse reactions. ADR incidence rate was 1.7 per 1,000. Blood samples were collected from patients with allergic reactions and their matched controls. Related biological indicators of allergic reactions were unified detected and analysed in order to explore the mechanism of allergic reaction and promote the clinical safety.
Case-Control Studies
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Drug Hypersensitivity
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etiology
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Drugs, Chinese Herbal
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adverse effects
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Humans
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Injections
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Product Surveillance, Postmarketing
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Prospective Studies
4.Erratum.
Mei Chun CHOU ; Ming Ting WU ; Chia Hui CHEN ; Mei Hua LEE ; Wen Sheng TZENG
Korean Journal of Radiology 2008;9(4):390-390
In previous case report entitled "Multidetector CT findings of a congenital coronary sinus anomaly: a report of two cases" by Chou et al. (Korean J Radiol 2008;9:S1-S6), there were mistakes. "The Figure 1A and 1B are the MDCT findings of normal coronary sinus of a normal individual." "The Figure 1C to 1E are the MDCT findings of congenital coronary sinus anomaly in 60-year-old woman with Ebstein's anomaly." "The Figure 2J and 2K are illustration of atresia of the right atrial ostium of the coronary sinus with/without PLSVC"
6.Determination of dimethyl ether in workplace air with gas chromatography.
Cheng-ming MENG ; Rui-qin ZHANG ; Wen-hua QIN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2012;30(2):142-143
OBJECTIVETo develop determination of dimethyl ether in workplace air by GC.
METHODSDimethyl ether were sampled with solvent desorption active carbon tube. The sampled carbon tube were desorbed by carbon tetrachloride, Elite-WAX column was used with temperature programmed from 40 to 90 degrees C, and the carrier gas programmed from 1.4 - 2.5 ml/min.
RESULTSThere was a good linearity (r = 0.9999) over the concentration of 0-63.91 microg/L, detection limit can reach 0.75 microg/ml.
CONCLUSIONThis method proved to be accurate and sensitive, to meet the determination of the dimethyl ether in workplace air.
Air Pollutants, Occupational ; analysis ; Chromatography, Gas ; methods ; Methyl Ethers ; analysis ; Workplace
7.Treatment of depression fractures of posterolateral tibial plateau through a modified anterolateral approach.
Guo-Jian XU ; Dong WENG ; Ming-Hua XIE ; Wen-Qing LIANG ; Guan-Biao HU ; Yu QIAN
China Journal of Orthopaedics and Traumatology 2015;28(3):256-259
OBJECTIVETo study the therapeutic effects of posterolateral depression fractures of the tibial plateau through a modified anterolateral approach.
METHODSFrom February 2011 to January 2012,13 patients with posterolateral depression fractures of the tibial plateau were treated through a modified anterolateral approach. There were 8 males and 5 females, ranging in age from 28 to 59 years old (49.2 years old on average). Data from patients were collected retrospectively as follows: X-ray, time of fracture healing and the complications of fracture healing. The patients were evaluated both clinically and radiologically according to the Rasmussen score system.
RESULTSAll the patients were followed up, and the duration ranged from 6 to 18 months (mean 13.7 months). All the patients got bony union. The average radiographic bony union time was 15.1 weeks (ranged, 11 to 17 weeks). No case of secondary articular depression was found. No complications such as malunion or joint stiffness were found. But 1 patient had superficial infection and 1 patient had common peroneal nerve injury. According to the Rasmussen score system,the mean radiological score was 16.50 ± 0.67 (ranged, 13 to 18), and the mean functional score was 25.20 ± 2.21 (ranged, 13 to 30). The mean range of knee motion was (125.3 ± 9.3)° (ranged, 0° to 135°).
CONCLUSIONTreatment of depression fractures of posterolateral tibial plateau with a modified anterolateral approach is a safe method with effective exposure, due to its stable fixation and relatively good outcome with minimal soft-tissue complications. It is regarded as an ideal procedure for depression fractures of posterolateral tibial plateau.
Adult ; Female ; Fracture Fixation, Internal ; methods ; Fracture Healing ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Tibial Fractures ; surgery
8.Expressions of IL-1?,IL-6,SCF,TPO on bone marrow stromal cells in patients with multiple myelo-ma
Wen-Yi SHEN ; Hua LU ; Xiao-Ming FEI ; Peng LIU ; Jian-Yong LI ;
Cancer Research and Clinic 2006;0(11):-
Objective To study multiple cytokine mRNA expressions of bone marrow stromal cells in patients with multiple myeloma(MM),as well as to explore the role of these cytokines in the occurrence and development of MM.Methods Semi-quantitiative RT-PCR was used to detect the mRNA expressions of IL- 1?,IL-6,SCF,TPO.Results The mRNA expression levels of IL-1? and IL-6 were higher than that of nor- mal controls and other hematological malignancies(P
9.Diagnostic value of fluid sign at MRI in vertebral compression fracture
yu-ping, PAN ; qi-xin, ZHUANG ; wen-bin, LI ; ming-hua, LI
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(01):-
3 month),fluid sign was observed in 2(3 vertebrae,3/26,11.5%). Conclusion Fluid sign is characteristic in acute,subacute and early chronic trauma vertebral compression fracture for bone marrow edema,while it is rare in metastatic tumor vertebral compression fracture.It may paly a role in the differentiation of benign and malignant vertebral compression fracture.
10.The effect of exposure to 50 Hz magnetic fields on the proliferation of different cell densities of human MG-63 osteosarcoma cell line in vitro
Wen-Chun ZHAO ; Hua WU ; Wei-Ming MA ; Hai-Hu HAO ; Hai-Jun ZHANG ; An HU ;
Chinese Journal of Physical Medicine and Rehabilitation 2003;0(05):-
Objective To study the effects of 50 Hz magnetic fields on the in vitro proliferation of human osteosareoma cell line MG-63 with different cell densities.Methods Four different magnetic intensities(1 mT, 2 mT,3 roT,4 mT)were used to stimulate the cells,and the experiment was repeated with different cell densities. The method of MTT was employed to evaluate the level of proliferation.Results Fifty Hz magnetic fields signifi- cantly affected the level of proliferation of human osteosareoma cell line MG-63,and the 2 mT intensity exerted the greatest influence on it.The effects of the magnetic field differed with different cell densities.Conclusion The effect of 50 Hz magnetic fields on the in vitro proliferation of human osteosarcoma cell line MG-63 was not only relat- ed to the magnetic intensity,but also the cell density,