Objective:To Integrated PACS and hospital information systems (HIS), and improve the efficiency of PACS, and improve the user experience. Methods:Base on deeply analysis of existing problems in system application, using process optimization, software optimization, and hardware upgrades manner optimize PACS. Results: PACS and HIS realized Integrated, improving the overall performance of the PACS. Enhance the user experience and expand the application scope of PACS. Conclusion: Deeply analysis of existing problems should be done before optimizing the system. Process optimization, software environment optimization should be considered as the most important and upgrading and replacement of the hardware as the secondary.

Abstract?AIM:To investigate the therapeutic effect of Lucentis in the treatment of anterior segment neovascularization ( ASNV ) induced by central retinal vein occlusion ( CRVO) .?METHODS: This was a retrospective case series study for patients with ASNV secondary to CRVO from January 2013 to December 2014 and treated with intravitreal injection of lucentis. Best visual acuity ( BCVA ) , intraocular pressure ( IOP ) , iris examination and gonioscopy, and if necessary, fluorescein angiography and optical coherence tomography, were recorded.The follow-up time was 6-13mo, the average was 9.1 ± 2.9mo.?RESULTS: Eighteen patients ( 18 eyes ) were treated with intravitreal injection of lucentis;15 patients (15 eyes) of the 18 were treated with panretinal photocoagulation;the other 3 patients 3 eyes were not received the photocoagulation because of vitreous opacity. One patient was treated with glaucoma valve implantation.Six patients with only neovascularization and without glaucoma were improved in visual acuity whose intraocular pressure was controlled after combined treatment.Of the patients with neovascular glaucoma ( n=12 ) , after intravitreal injection of lucentis and panretinal photocoagulation, the IOP was controlled in 4 patients (4 eyes);the IOP of another 7 cases reduced but glaucoma drugs were still needed.One patient ( 1 eye ) received glaucoma valve implantation because of bad control on IOP with worse vision after implantation.The rubeosis disappeared in all patients.?CONCLUSION:Intravitreal injection of lucentis can stop neovascularization and help to control IOP.In the early stage without neovascular glaucoma, lucentis has better effects, which means early detection and intervention are important.

Because absence of lymphoadenopathy, and often associated with haemophagocytic syndrome, the intravascular malignant lymphoma(IVL) is easy mistaken as malignant histiocytosis or connective tissue disease or vasculitis, the diagnosis was difficult while patients were alive. The clinical course of this disorder (IVL)was aggressive and carried a poor prognosis. The cases of this disorder are not too rare to be seen in our country. To enhance one′s ability to differentiate disorder in unknown fever diseases are extremely necessary.

A deficient of plasma VW factor-cleaving protease (ADAMTS13) and appearance of unusually large multimers induced platelets aggregation in capillaries and arterioles. It was critical pathogenesis of thrombotic thrombocytopenia purpura (TTP). ADAMTS13 activity has been measured over 1000patients of TTP and hemolysis uremia syndrome (HUS) since 1997. Diagnostic sensitivity and specificity,as well as clinical significance of ADAMTS13 deficiency for TTP patients were evaluated,and synthetical diagnosis basis of TTP were raised.

Adult ; Dermatitis, Contact ; etiology ; Humans ; Male ; Middle Aged ; Nitrobenzenes ; poisoning ; Young Adult

Infantile spasms is a type of refractory epilepsy syndrome.This epilepsy syndrome is characterized by special tonic spasms,a peculiar set of electroencephalographic findings termed hypsarrhythmia,and arrest of psychomotor development in most patients.The etiology is not clearly understood.Recently,mutations of the arista less related homeobox gene(ARX),cyclin-dependent kinase-like 5(CDKL5)/se-rine/threonine kinase 9 gene(STK9),membrane associated guanylate kinase 2 gene(MAGI2),et al,and abnormal chromosome had been found to be responsible for infantile spasms.In this review,progress of infantile spasms in molecular genetics are discussed.

Biofilms

[Objective]To evaluate the two plates internal fixation treating the distal humeral comminuted and complicated fracture.[Method]Twenty-eight patient with comminuted distal humeral fracture were treated with the double-plate internal fixation from April 2004 to April 2007.According to AO/ASIF classification method,all fractures were C types.There were 9 C1 types,15 C2 types,4 C3 types.All cases were taken from the middle of posterior elbow incision.The patients were treated with the open reduction and double plate internal fixation.Fifteen cases were done through the triceps tongue-shaped flap,13 cases were olecranon osteotomy (including one case with olecranon fractures with ipsilateral).Surgical steps included:the articular surface reduction of intra-articular fractures,small temporary Kirschner wire fixation,making the complete fractures into simple comminuted fractures of humerl condylar fractures,then resetting metaphysis.Internal fixation method used the restruction plate according to the size of fracture.The restruction plate was fixed in the back of the distal humeral radial column.One-third of a good-shaped tubular plate was used to fix the inner edge of humeral ulnar column,two 90 ? of each other into the plane separately fixed on the inner lateral humeral column.[Result]All cases were followed up for an average of 17 months(ranged,8-33 months).Fracture healing time ranged 8-16 weeks.Myositis ossificans was found in 1 case,joint space narrowing was found in 4 cases.No non-union and ulnar nerve injury were found.The final good-to-excellent rate was 82.1%.[Conclusion]The distal humeral comminuted fracture has complicated structure.The internal fixation with two plates and screws,and early functional exercise could improve the elbow function.It has satisfactory curative effect in clinic.

Objective To investigate the method for the treatment of haemorrhage of all ventricles.Methods 46 cases were treated by continuous extrinsic drainage through puncture of the lateral ventricle which accumulated more blood combming with substitution of CSF by meams of lumbus puncture per day.Urokinase was injected into ventricle at regular intervals.Results The symptoms were improved.Head CT were reexamined in 41 cases,which showed disappearance of hematocele in ventricle within 4～15 days.Except for 5 cases of death,other cases recovered from the disease.Conclusion The hematocele above and below the duct in ventricle can be eliminated by this method,and the mortality rate can reduced greatly and the quality of survival can improved.

Objective: To investigate the effect of lysophosphatidic acid (LPA) on growth, invasion and metastasis of ovarian cancer cell lines SKOV3, 3AO and CAOV3. Methods: The ovarian cancer cell line 3AO, SKOV3 and CAOV3 were cultured and incubated with LPA at different concentrations for 2, 4, 6, 16 and 24 h. The control group was incubated with PBS instead of LPA. The effect of LPA on cell proliferation was detected by MTT assay. The invasion ability of ovarian cancer cells was evaluated by the Boyden chamber invasion test in vitro. The secretion of cytokines in the supernatant of cultured CAOV3 was measured by ELISA after being stimulated by LPA. Results: LPA interference greatly enhanced cell growth in a concentration-dependent manner. Boyden chamber invasion test showed that the invasion indices of 3AO and CAOV3 test groups were all higher than those of corresponding control groups, respectively. The difference was significant between different concentration groups. But the difference was not significant between the 3AO and CAOV3 cell lines. The expression of cytokines in supernatant fluid of CAOV3 cells had corresponding changes after LPA interference at different concentrations. Conclusion: LPA interference significantly enhances the growth of ovarian cancer cells in vitro. The invasion indices and the levels of migration-related cytokines have corresponding changes after LPA interference at different concentrations. It indicates that LPA might have the biologic significance in invasion and metastasis of epithelial ovarian cancer.