BACKGROUND: Effect of exercise training on ultrastructure of skeletal muscle is a focus of quantified cytobiology in sports medicine. OBJECTIVE: To explore the changes of transportation function of calcium ion in sarcoplasmic reticulum of muscle in the model of reduced training after endurance training. DESIGN, TIME AND SETTING: The randomized animal trial was performed at Xi'an Sports Institute from April to July 2006, and the biochemical test was performed at the Animal Experimental Center of Xi'an Jiaotong University in July 2006. MATERIALS: Thirty-nine healthy 2-month-old male SD weighing (220?20) g were selected. METHODS: Five rats were used in the preliminary experiment, and the others were randomly divided to normal control group (n=8), endurance training group (n=8) and reduced training group (n=18). The increasing training period of endurance training group and reduced training group lasted for 6 weeks, and then reduced training group was randomly divided to 3 groups according to reduced training cycle: 2, 4 and 6 weeks group. The rats did increasing endurance loading exercise on a treadmill, while reduced intensity was used in reduced training group. MAIN OUTCOME MEASURES: Enzyme coupling method and fluorescence probe technology were used to detect sarcoplasmic reticulum Ca2+-ATPase (adenosine triphosphatase) and maximum Ca2+ uptake and release of gastrocnemius muscle. RESULTS: The activity of Ca2+-ATPase in endurance training group was significantly increased compared with normal control group (P 0.05); reduced training 4 and 6 weeks groups were significantly reduced compared with endurance training group (P 0.05); while the maximum uptake and release of Ca2+ in sarcoplasmic reticulum of reduced training 4 and 6 weeks group was significantly reduced (P

BACKGROUND:The androgen response to resistance exercise is one of hot topics in sports science research. At present, the androgen responses to resistance exercise show different results. There are different androgen changing trends under different resistance exercise interventions.
OBJECTIVE:To have a deep insight into the influence of resistance exercise on the response of human body androgen, clarify research progress in androgen response to resistance exercise, and provide the basic theory for monitoring resistance training.
METHODS:Literatures and paper reports about androgen response to resistance exercise are electronical y retrieved from the American Biological Medical Literature Database PubMed from 1986 and 2013. Final y 46 literatures addressing the research progress is analyzed about androgen responses to resistance exercise were included.
RESULTS AND CONCLUSION:Studies have shown that, weight lifting (power snatch and power clean), squating, and deadlifting produced higher testosterone levels than the smal muscle groups. Under the same load, eccentric and concentric contractions produced the same hormone response. Adequate training amount and intensity may change the circulating testosterone levels. Short sports intermittent time led to a higher testosterone response than the long intermittent time. The free testosterone levels in youth group were significantly increased compared with the older group before and after exercise. Nutrition intervention affected acute testosterone responses to resistance exercise. Changes in exercise intensity and amount wil alter quiet testosterone levels, once returned to normal training, testosterone levels wil return to baseline values. Resistance exercise can increase androgen receptor content in human skeletal muscles.

Chronic obstructive pulmonary disease(COPD) is a common condition among the old,which remains a main cause of death due to its high fatality.Airway remodeling is one of its pathological features.This article reviews the pathological changes and imageological assessment of COPD airway remodeling,its correlation with microbes and its pathogenesis and therapies.

AlM: To investigate the risk factors of diabetic retinopathy ( DR) in type 2 diabetes patients.METHODS:A total of 380 cases of type 2 diabetes were selected from January 2014 to June 2014, divided into DR group (126 cases) and non-diabetic retinopathy ( NDR) as control group (254 cases), all patients were underwent medical history, physical examinations, laboratory and assistance examinations. The prevalence and single factor and multiple factors of DR were analysed by the logistic regression model.RESULTS: The univariate logistic regression analysis showed that DR was associated with diabetes duration, systolic blood pressure, triglyceride, total cholesterol, low - density lipoprotein, urine protein, intraocular pressure, carotid intima - media thickness, peripheral neuropathy disease was the related risk factors for DR. ln multiple logistic regression analysis, only duration was the related risk factors for DR.CONCLUSlON:The occurrence of DR is the outcome of combined action of multiple factors, duration is an independent risk factor for occurrence of DR.

China ; Humans ; Hypertension ; diagnosis ; epidemiology ; therapy

Acupuncture Therapy ; Adolescent ; Female ; Humans ; Olfaction Disorders ; physiopathology ; therapy ; Smell

The incidence of thyroid cancer has increased sharply year by year. Thyroid cancer ranked from the 14th in 2003 to the 4th in 2012 most common cancers in female in Beijing. Surgery is still main solution for thyroid cancer, there are two operative procedure for thyroid cancer: total thyroidectomy, lateral lobectomy and isthmus resection. The surgeon must pay attention to intraoperative recurrent laryngeal nerve and parathyroid injury, with particular emphasis on the prevention of total thyroidectomy complications. Precise dissection of thyroid capsule, intraoperative recurrent laryngeal nerve monitoring and application of lymphatic mapping to recognize and protect negative stained parathyroid by using carbon nanoparticles tracer is prone to reduce the incidence of recurrent laryngeal nerve and parathyroid injury in the total thyroidectomy.
Attention ; Beijing ; epidemiology ; Female ; Humans ; Incidence ; Intraoperative Complications ; prevention & control ; Monitoring, Intraoperative ; Nanoparticles ; Recurrent Laryngeal Nerve Injuries ; prevention & control ; Thyroid Neoplasms ; epidemiology ; Thyroidectomy ; adverse effects

Air Pollutants, Occupational ; analysis ; classification ; Organic Chemicals ; analysis ; classification ; Workplace

Objective To observe the clinical efficacy of Shenqi Fuzheng injection combined with TC regimen in the treatment of advanced epithelial ovarian cancer.Methods A total of 56 patients with advanced epithelial ovarian cancer were divided into treatment group and control group by random digits table method with 28 cases each.In treatment group,the patients received TC regimen (paclitaxel plus carboplatin) chemotherapy,while giving patients Shenqi Fuzheng injection in the process of chemotherapy.In control group,the patients only received TC regimen chemotherapy.Tcell subsets and NK cell changes,changes in the quality of life,the recent efficacy and toxicity were observed in two groups.Results CD3+,CD4+,CD4+/CD8+ and NK cell levels after treatment(0.6924 ± 0.0114,0.3738 ± 0.0234,1.48 ± 2.09,0.1849 ± 0.0210) were higher and CD8+ level (0.2528 ± 0.0112) was lower than those before treatment (0.6415 ± 0.0422,0.3254 ± 0.0312,1.02 ± 1.18,0.1378 ± 0.0126,0.3197 ± 0.0265 ) in treatment group (P ＜ 0.05).Compared with control group (0.6167 ± 0.0347,0.3125 ± 0.0334,1.01 ± 3.31,0.1241 ± 0.0324,0.3101 ± 0.0101 ),CD3+,CD4+,CD4+/CD8+,NK cell levels were increased and CD8+ was decreased in treatment group (P ＜ 0.05).The quality of life improvement in treatment group [60.7％ (17/28)] was higher than that in control group [32.1％ (9/28)] (P ＜ 0.05 ).There was no significant difference in the objective effective power between two groups [89.3 ％ (25/28) vs.82.1％ (23/28)] (P ＞ 0.05 ).The incidence of more than degree Ⅱ marrow depression (leucocyte decreasing,anemia,platelet decreasing) in treatment group was lower than that in control group [32.1％(9/28) vs.71.4％(20/28),25.0％(7/28) vs.42.9％(12/28),17.9％(5/28) vs.35.7％ (10/28)] (P ＜ 0.05).Conclusion Shenqi Fuzheng injection combined with TC regimen in the treatment of advanced epithelial ovarian cancer is safe and effective,it plays an important role in improving immune function,the quality of life and protecting bone marrow function of patients with advanced epithelial ovarian cancer.

Objective:To evaluate the diagnostic value of PET/CT fusion images in the research field of metastatic tumors of the body by the comparison of CT,SPECT or PET images.Methods:The analysis was based on 19 cases with 60 metastatic lesions.The final diagnoses were confirmed by surgery,biopsy and pathology.CT,SPECT or PET and PET/CT were applied in all cases.CT scanning was applied in 19 cases.Among them,there were 9 plain examinations,and on the basis of that,the other 10 cases were applied enhancement scanning.SPECT was applied in 11 cases.Among them,there were also another 8 cases which were applied PET.Combined PET/CT examinations were performed in 19 cases.PET/CT was separately compared with CT,SPECT or PET findings,and the its numbers,localization,size,the distrubution of radionuclide,the involvement of lymph node and local swelling of soft tissues of the lesions were recorded.Results: There were 9 cases of pulmonary metastasis and the detective rate of PET/CT was 100%(29/29 cases),SPECT or PET 86.2%(25/29 cases),CT 82.8%(24/29 cases);7 cases of spine metastasis and the detective rate of PET/CT was 100%(17/17 cases),SPECT or PET 88.2%(15/17 cases),CT 76.5%(13/17 cases);3 cases of hepatic metastasis,and the detective rate of PET/CT was 100%(14/14 cases),SPECT or PET 71.4%(10/14 cases),CT 78.6%(11/14 cases)respectively.Conclusion:The shape and anatomic position of metastatic lesion can be clearly detected on CT image;nuclear medicine images such as SPECT,PET can provide excellent information on functional biology.Referring to PET/CT,it is a very useful method in detecting lesions of the shape and construction,and it can also provide more functional information,localization and characterization of metastatic lesion,PET/CT image can differentiate physiologic uptake,and meanwhile promote the differentiation of its physiologic intake.