Biomarkers ; Carcinogens ; Epigenesis, Genetic ; Humans

Gynecological malignancies have seriously affected women′s living quality and survival.In recent years,studies have shown that androgen is closely related to the occurrence and development of gynecologic malignancies.In this paper,we mainly discussed the mechanism of androgen on gynecologic malignancies.

Objective To inverstigate the CT findings of non-Hodgkin’s lymphomas in orbit and paranasal sinuses,nasal cavity.Methods 12 patients with non-Hodgkin’s lymphomas in orb it and paranasal sinuses,nasal cavity diagnosed pathology retrospectivly were an alyzed based on their CT data. Results 12 cases of all were non-Hodgin’s lymphoma.Ther e were lymphoma of orbit in 8 cases, lymphoma of maxillary sinus in 3 cases, lym phoma of nasal in 1 case .There was eyelid tumor in 3 cases, soft tissue tumefac tion in adjacent eyelid in 2 cases,soft tissue tumefaction in adjacent maxillary region of nose back in 3 cases and local bone absorption in 2 cases.Conclusion Tumors in orbit and maxillary sinus nasal cavi ty were not concomitant with bone destruction. The sicken tumefaction or tumors formed in adjacent eyelid and maxillay region of nose back are important clue of lymphoma.

Objective Toexplorethepatencyofbridgevesselsinpatientsaftercoronaryarterytransplantation,andto providereferencefortheselectionofclinicalbridgevessels.Methods Dataof32patientsunderwentcoronaryangiography aftercoronaryarterybypassgraftingwereselectedandanalyzedretrospectively.Theoverallusageandpatencyofthegreat saphenousveingraft(SVG),theleftinternalmammaryartery(LIMA)andtheradialartery(RA)wereanalyzed.Thepatency ofthenearfuture(5years),themediumterm(5-10years)andlongterm(>10years)werecomparedbetweenthethreekinds ofbridgingvascularvessels.TheRAocclusionwasanalyzed. Results Thetotalnumberofbridgevesselsusedin 32 patientswas85,only1caseusedrightinternalmammaryartery(RIMA),theothersusedSVG,LIMAandRA,inwhich48, 23and13brancheswereusedrespectively.ThepatencyratesofSVG,LIMAandRAwere25%(12/48),73.91%(17/23)and 69.23(9/13)respectively.Therecentandmedium-termpatencyratesofallbridgevesselsshowedadecreasingtrend,in whichtherecentpatencyrateofSVGwassignificantlyhigherthanthatinLIMA,theintermediatepatencyratesofLIMAand SVGwerehigherthanthatofRA,andthelong-termpatencyrateofRAwassignificantlyhigherthanthatofLIMAandSVG. Therewasseverestenosis(＞90%)orocclusionintheproximalsegmentofanastomosisinthe9radialarteriesunobstructed. Conclusion TheutilizationrateofRAisstilllow,andtheoverallpatencyrateofRAissuperiortotheSVG.RAcanbe usedasthesecondoptimalbridgevessel.ThepatientselectionandRAevaluationshouldbedonebeforeapplyingRA.The proximalstenosisdegreeoftargetvesselsignificantlyaffectsthelong-termpatencyofRA.

Objective To study whether the mechanism of mifepristone in treating adenomyosis is suppressing matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-1(MMP-9/TIMP-1). Methods Thirty-five patients in the mifepristone treated group(19 cases of adenomyosis) and the control group(16 cases of adenomyosis,non-drug treated) underwent hysterectomy.Endometrium was looked as eutopic endometrium and adenomyosis as ectopic endometrium.Expression of MMP-9 and TIMP-1 in eutopic and ectopic endometrium were measured by immunohistochemical techniques. Results The ectopic endometrium of the mifepristone treated group expressed lower level of MMP-9,higher level of TIMP-1 and lower ratio of MMP-9/TIMP-1 than the ectopic endometrium of the control group(P

Child ; Erdheim-Chester Disease ; Female ; Humans

Objective To assess the usefulness of a computer-aided detection(CAD)system on detecting the pulmonary nodules in digital chest radiography.Methods Three hundred and twenty-eight digital chest radiographies along with corresponding chest computed tomography were selected for this study. Two senior chest radiologists interpreted these cases using the CAD system and marked the locations and sizes of all nodules with consensus,which were stored in a computer system as Gold Standard to evaluate the performance of the CAD system.Eight radiologists of various experience read these selected cases without and with the aid of CAD system and their results were stored in a computer system.The radiologists' performance was evaluated by using the receiver operating characteristic analysis.Comparison is made regarding the difference in Az values when CAD was not used versus when CAD was used by using the paired-samples t test.Results For small nodules,the sensitivity of this computer system used by the two senior chest radiologists in 100 digital radiographs was 78.1%(118.0/151).Without and with the assistance of CAD system,the nodule detection sensitivity of the radiology residents was 62.4% (94.2/151),77.4%(116.8/151)respectively,and the area under the curve of radiology residents was 0.769,0.836 respectively.Statistical analysis showed there was statistically significant difference between interpretation without and with the CAD system(P0.05).Conclusions This CAD system can help to enhance the radiologists' ability to detect small pulmonary nodules.This is especially helpful for radiology residents.

Objective To investigate the effect of rosiglitazone (ROS),a peroxisome poliferator- activated receptor (PPAR)?ligand,combined with all-trans retinoic acid (ATRA) on anti-angiogenesis of transplanted gastric cancer in nude mice,and to explore the mechanism of anti-angiogenesis prelimina- rily.Methods The model of xenograft tumor in nude mice were established by inoculating human gastric cancer cells line MGC803 (lower differentiated) into the back of nude mice subcutaneously.The cancer- bearing nude mice were divided randomly into 5 groups:group 1 (n=6) with no treatment;ROS treat- ment (group 2,n=6),ROS combined ATRA treatment including:low dose treatment (group 3,n= 6),moderate dose treatment (group 4,n=6) and high dose treatment (group 5,n=6).After treated for forty days,the volume change of tumor and tumor inhibition rates were observed.The expression of CD34,vascular endothelial growth factor (VEGF) in grafts were detected by immunohistochemical and calculated the difference of MVD.The mRNA expression levels of VEGF,HIF-l?were detected by RT- PCR assay accordingly.Results①The volume of tumor was significantly decreased in ROS treatment group compared with group 1 (P＜0.01).The tumor inhibition rates of group 2 were similar to group 3 (P＞0.05).With the increasing of the dose of ROS the tumor inhibition rates were increased.They were dose-dependent in specified dose-range.②ROS could inhibit angiogenesis of xenograft tumor and depress expression of mRNA of VEGF and HIF-l?.When ROS combined with ATRA,the increasing of dose of ROS,inhibiting angiogenesis of tumor and depressing expression of mRNA of VEGF and HIF-l?were found (P＜0.05).Conclusion ROS (25 mg?kg?2 d~(-1)) can inhibit the growth of tumor,and ROS combined with ATRA can further inhibit the growth of tumor,which may be through the path of PTEN by inhibiting the angiogenesis of tumor

AIM: To study the absorption and distribution characteristics of oxybutynin (OXY) oral tablet and transdermal gel. METHODS: A single dose of 0.1 g OXY transdermal gel (2 mg OXY) was applied to abdominal area about 4 cm2 and 0.5 mg immediate-release tablet was orally given to 48 rats in a randomized, open-label, control design test. The plasma, bladder and liver tissue were collected, disposed and analyzed and OXY pharmacokinetic parameters were calculated and evaluated. RESULTS: The Cmax of OXY transdermal gel and oral tablets in bladder are approximately 800 and 70 times higher than those in plasma. The plasma half life of OXY gel delayed 5.99 h, tablets 2.18 h. CONCLUSION: OXY gel show better pharmacokinetic properties, characterized with long half life and high target organ concentrations than those of tablets.