1.Post-Traumatic Cerebral Infarction Following Low-Energy Penetrating Craniocerebral Injury Caused by a Nail.
Po Chuan CHEN ; Shih Hung TSAI ; Yu Long CHEN ; Wen I LIAO
Journal of Korean Neurosurgical Society 2014;55(5):293-295
Post-traumatic cerebral infarction (PTCI) is a secondary insult which causes global cerebral hypoxia or hypoperfusion after traumatic brain injury, and carries a remarkable high mortality rate. PTCI is usually caused by blunt brain injury with gross hematoma and/or brain herniation. Herein, we present the case of a 91-year-old male who had sustained PTCI following a low-energy penetrating craniocerebral injury due to a nail without evidence of hematoma. The patient survived after a decompressive craniectomy, but permanent neurological damage occurred. This is the first case of profound PTCI following a low-energy penetrating craniocerebral nail injury and reminds clinicians of possibility this rare dreadful complication for care of head-injured patients.
Brain
;
Brain Edema
;
Brain Injuries
;
Cerebral Infarction*
;
Craniocerebral Trauma*
;
Decompressive Craniectomy
;
Hematoma
;
Humans
;
Hypoxia, Brain
;
Male
;
Mortality
2.Knockout SQLE in melanoma cells potentiates anti-tumor immunity via improving CD8 + T cell infiltration in tumor microenvironment
Yao Ding ; Wen Liu ; Yiran Liao ; Shun Lei ; Yan Zhang ; Yezi Chen ; Yi Gong ; Qizhao Huang
Acta Universitatis Medicinalis Anhui 2024;59(8):1315-1322
Objective :
To investigate the role of squalene epoxidase (SQLE) knockout in anti-tumor effect vial im- proving CD8 + T cell infiltration in melanoma tumor microenvironment.
Methods :
Both immunodeficient and immu- nocompetent mice were inoculated with SQLE knockout B16F10 cells to determine the cell-autonomous and non-au- tonomous regulation of malignancy.Antibody blockade ,Luminex multiplex assays ,and flow cytometry were em- ployed to explore the impact of SQLE gene knockout on the secretion of cytokines / chemokines and immune cell in- filtration.Bioinformatics analysis was conducted to validate the correlation between SQLE expression and immune infiltration as well as clinical prognosis in melanoma patients.
Results :
Compared with immunodeficient mice, SQLE knockout significantly inhibited melanoma proliferation in immunocompetent mice and prolonged their surviv- al.SQLE knockout induced the secretion of cytokines and chemokines from tumor cells,improved CD8 + T cell in- filtration in the tumor microenvironment,thereby potentiating anti-tumor immunity.Bioinformatics analysis sugges- ted a significant correlation between SQLE and its corresponding immune infiltration markers with the prognosis of melanoma patients.
Conclusion
SQLE regulates anti-tumor immunity by controlling cytokines and chemokines re- leasing in tumor microenvironment,thus holding promise as a novel tumor immunotherapy target and efficacy predic- tion molecular indicator.
3.Clinical Features and Computed Tomography Characteristics of Non-Klebsiella pneumoniae Liver Abscesses in Elderly (>65 Years) and Nonelderly Patients.
Chih Weim HSIANG ; Chang Hsien LIU ; Hsiu Lung FAN ; Kai Hsiung KO ; Chih Yung YU ; Hong Hau WANG ; Wen I LIAO ; Hsian He HSU ; Wei Chou CHANG
Yonsei Medical Journal 2015;56(2):519-528
PURPOSE: To compare the clinical and computed tomography (CT) appearances of liver abscesses caused by non-Klebsiella pneumoniae bacterial pathogens in elderly and nonelderly patients. MATERIALS AND METHODS: Eighty patients with confirmed non-Klebsiella pneumoniae liver abscesses (non-KPLAs) were enrolled and divided into two age groups: elderly (age > or =65 years, n=42) and nonelderly (age <65 years, n=38). Diagnosis of non-KPLA was established by pus and/or blood culture. We compared clinical presentations, outcomes, and CT characteristics of the two groups, and performed multivariate analysis for significant variables and receiver-operating-characteristic analysis to determine the cutoff value of abscess diameter for predicting non-KPLA. RESULTS: Elderly patients with non-KPLA were associated with a longer hospital stay (p<0.01). Regarding etiology, biliary sources had a strong association in the elderly group (p<0.01), and chronic liver diseases were related to the nonelderly group (p<0.01). Non-KPLAs (52.5%) tended to show a large, multiloculated appearance in the elderly group and were associated with bile duct dilatation (p<0.01), compared with the nonelderly group. The abscess diameter (cutoff value, 5.2 cm; area under the curve, 0.78) between the two groups was predicted. In multivariate analysis, underlying biliary tract disease [odds ratio (OR), 3.58, p<0.05], abscess diameter (OR, 2.40, p<0.05), and multiloculated abscess (OR, 1.19, p<0.01) independently predicted elderly patients with non-KPLA. CONCLUSION: In the elderly patients with non-KPLA, a large, multiloculated abscess with a diameter greater than 5.2 cm was the predominant imaging feature.
Adult
;
Aged
;
Aged, 80 and over
;
Bacterial Infections/*complications/*radiography
;
Female
;
Humans
;
Klebsiella Infections/microbiology
;
Klebsiella pneumoniae
;
Length of Stay
;
Liver Abscess/complications/microbiology/*radiography
;
Logistic Models
;
Male
;
Microscopy
;
Middle Aged
;
Multivariate Analysis
;
ROC Curve
;
Retrospective Studies
;
Tomography, X-Ray Computed/*methods
4.Clinical Features and Computed Tomography Characteristics of Non-Klebsiella pneumoniae Liver Abscesses in Elderly (>65 Years) and Nonelderly Patients.
Chih Weim HSIANG ; Chang Hsien LIU ; Hsiu Lung FAN ; Kai Hsiung KO ; Chih Yung YU ; Hong Hau WANG ; Wen I LIAO ; Hsian He HSU ; Wei Chou CHANG
Yonsei Medical Journal 2015;56(2):519-528
PURPOSE: To compare the clinical and computed tomography (CT) appearances of liver abscesses caused by non-Klebsiella pneumoniae bacterial pathogens in elderly and nonelderly patients. MATERIALS AND METHODS: Eighty patients with confirmed non-Klebsiella pneumoniae liver abscesses (non-KPLAs) were enrolled and divided into two age groups: elderly (age > or =65 years, n=42) and nonelderly (age <65 years, n=38). Diagnosis of non-KPLA was established by pus and/or blood culture. We compared clinical presentations, outcomes, and CT characteristics of the two groups, and performed multivariate analysis for significant variables and receiver-operating-characteristic analysis to determine the cutoff value of abscess diameter for predicting non-KPLA. RESULTS: Elderly patients with non-KPLA were associated with a longer hospital stay (p<0.01). Regarding etiology, biliary sources had a strong association in the elderly group (p<0.01), and chronic liver diseases were related to the nonelderly group (p<0.01). Non-KPLAs (52.5%) tended to show a large, multiloculated appearance in the elderly group and were associated with bile duct dilatation (p<0.01), compared with the nonelderly group. The abscess diameter (cutoff value, 5.2 cm; area under the curve, 0.78) between the two groups was predicted. In multivariate analysis, underlying biliary tract disease [odds ratio (OR), 3.58, p<0.05], abscess diameter (OR, 2.40, p<0.05), and multiloculated abscess (OR, 1.19, p<0.01) independently predicted elderly patients with non-KPLA. CONCLUSION: In the elderly patients with non-KPLA, a large, multiloculated abscess with a diameter greater than 5.2 cm was the predominant imaging feature.
Adult
;
Aged
;
Aged, 80 and over
;
Bacterial Infections/*complications/*radiography
;
Female
;
Humans
;
Klebsiella Infections/microbiology
;
Klebsiella pneumoniae
;
Length of Stay
;
Liver Abscess/complications/microbiology/*radiography
;
Logistic Models
;
Male
;
Microscopy
;
Middle Aged
;
Multivariate Analysis
;
ROC Curve
;
Retrospective Studies
;
Tomography, X-Ray Computed/*methods
5.Comparison of Clinical Characteristics and Outcomes of Pediatric and Adult Patients with Coronavirus Disease 2019 in Shenzhen, China.
Fang WANG ; Chang Xiang LAI ; Peng Yu HUANG ; Jia Ming LIU ; Xian Feng WANG ; Qi Yuan TANG ; Xuan ZHOU ; Wen Jie XIAN ; Rui Kun CHEN ; Xuan LI ; Zhi Yu LI ; Li Qun LIAO ; Qing HE ; Lei LIU
Biomedical and Environmental Sciences 2020;33(12):906-915
Objective:
Here we aimed to investigate the difference in clinical characteristics and outcomes between pediatric and adult patients with COVID-19.
Methods:
A total of 333 consecutive patients with laboratory-confirmed SARS-CoV-2 infection treated in the departments of Internal medicine of Shenzhen Third People's Hospital from January 11
Results:
Compared with adult patients, pediatric patients had a shorter time of symptom onset to hospitalization than adults [median time, 1 (
Conclusion
Pediatric patients with COVID-19 had milder or less clinical symptoms, less evident pulmonary imaging changes, better prognosis, and shorter length of hospital stay.
COVID-19/therapy*
;
Child
;
China/epidemiology*
;
Female
;
Hospitalization
;
Humans
;
Length of Stay
;
Male
;
Retrospective Studies
;
SARS-CoV-2
;
Treatment Outcome