2.Treatment of severe intestinal flora alteration induced by the Cefoperazone with the filtrate of fresh human dejecta
Hao ZHOU ; Wen-liang ZHAO ; Guo-chang ZHOU
Chinese Journal of Rehabilitation Theory and Practice 2004;10(7):438-439
Objective To observe the effect of filtrate of normal human fresh dejecta on intestinal flora alteration.Methods 5 severe patients who treated with Cefoperazone suffered in intestinal flora alteration, 4 cases with candida albicans ans, 1 with Welch's basillus. After diagnosing, preserving clyster was done with filtrate of normal human fresh dejecta.Results 1 or 2 days after the treatment, the intestinal flora alteration disappeared.Conclusion The filtrate of normal human fresh dejecta is effective on the treatment of intestinal flora alternation.
3.Primary mucosal melanoma of the nasal cavity: a linicopathological analysis of 17 cases
Wen LIU ; Zhi ZENG ; Heng ZHOU ; Hao WU ; Jingping YUAN
Chinese Journal of Clinical and Experimental Pathology 2017;33(2):169-173
Purpose To study the clinicopathologic features and differential diagnosis of primary mucosal melanoma of the nasal cavity (PMMNC).Methods 17 cases of PMMNC diagnosed from January 2003 to September 2016 were studied by clinical pathological analysis and immunohistochemical staining,and relevant literatures were reviewed.Results 73% of the PMMNC was characterized by unilateral nasal congestion and intermittent epistaxis and 61% of the PMMNC occurred in the nasal septum and nasal side wall.Microscopically,the organizational structure and morphology were complex and diverse,which had several cell types including epithelioid cell type (6cases,35.3%),spindle cell type (3 cases,17.6%) and snall cell type (5 cases,29.4%),the other 3 cases (17.6%)were mixed cell type.Mitotic activity and tumor necrosis were more likely to be seen in PMMNC,among other clinicopathological features with a small amount of fibrous stroma and melanoma and rich blood vessels.The immunohistochemical study showed that the positive rate of S-100 and HMB-45 were both 93.8%(15 cases) and those of Melan-A and vimentin were both 87.5% (14 cases),while CK and EMA were both negative (16 cases).Conclusion PMMNC is a rare disease and the phenotype of S-100,HMB-45,Melan-A and vimentin are useful for diagnosis of PMMNC.
4.Investigation on ergonomic load of ceramic and porcelain manufacturing workers.
Si-hao LIN ; Pei-yuan ZHOU ; Wen-juan TANG
Chinese Journal of Industrial Hygiene and Occupational Diseases 2010;28(3):following 240-following 240
Ceramics
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Ergonomics
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Female
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Humans
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Male
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Occupational Exposure
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Workload
5.Cloning and analysis of STR gene and its promoter from Uncaria
Hao ZHOU ; Xing-xing LU ; Wen-wen AO ; Hai-min LIAO ; Ming-sheng ZHANG ; Wei QIANG
Acta Pharmaceutica Sinica 2022;57(5):1526-1536
On the basis of the
6.The evaluations of chemotherapy with pemetrexed for postoperative recurrence of non-small cell lung cancer patients
Wenxiong ZHOU ; Jia ZHOU ; Hao CHI ; Yaoyao WU ; Wen GE ; Jianjun XU
China Oncology 2010;20(3):218-221
Background and purpose:Five-year survival rate of post-operation patients with non-small cell lung cancer(NSCLC)is less than 40%.Treatments after recurrence are difficult.Our study aimed to evaluate the efficacy of pemetrexed on postoperative recurrence of NSCLC.Methods:From Jan.2006 to Sep.2008,40 NSCLC with postoperative recurrence were observed.All patients had received pemetrexed(ALIMTA)500 mg/m2 or carboplatin eonbined.Results:Among the 40 patients,partial response in 10 patients(25.00%),stable disease in 19 patients(47.50%),progressive disease in 11 patients(27.50%).The total response rate was 25.00%and clinical benefit control rate was 72.50%.Pemetrexed had significantly better disease control rate in female than in male (9 1.30% vs 47.06%,P=0.034),in adenocarcinoma patients than in non-adenocarcinoma's(87.10% vs 22.22%,P=0.001).Median overall survival time(MST)was 10.70 months.Progression-free survival time(PFS)was 5.18 months.Adenocarcinoma patients had longer PFS than non-adenocarcinoma patients.Conclusion:Pemetrexed demonstrates significant antitumor activity and good tolerance in these patients.
7.MicroRNA expression profiles in early mycosis fungoides
Guangping WANG ; Nana NI ; Xiaowei ZHOU ; Ying YANG ; Hao SONG ; Sijian WEN ; Hao CHEN ; Xiulian XU ; Jianfang SUN
Chinese Journal of Dermatology 2016;49(11):785-788
Objective To screen microRNAs(miRNAs)related to early mycosis fungoides(MF). Methods A high?throughput miRNA PCR array was used to determine miRNA expression profiles in skin lesions of 6 patients with early MF (early MF group) and 6 patients with lichen planus (control group), followed by screening of differentially expressed miRNAs between the two groups. Then, real?time fluorescence?based quantitative PCR(RT?qPCR)was performed to verify the differentially expressed miRNAs in lesional specimens from 13 patients with early MF and 13 patients with eczema or lichen planus, as well as in Myla cells and normal human T?lymphocytes. Results The high?throughput miRNA PCR array showed that the expressions of hsa?miR?378a?5p, hsa?miR?107 and hsa?miR?302c?3p were significantly higher in the early MF group than in the control group(all P<0.05). For skin lesions, the results from RT?qPCR were similar to those from the miRNA array assay. Compared with normal human peripheral blood T?lymphocytes, Myla cells showed significantly increased expressions of hsa?miR?378a?5p and hsa?miR?107, which was consistent with the results from the miRNA array assay. However, no significant difference was observed in the expression of hsa?miR?302c?3p between the two kinds of cells. Conclusion MiRNA expression profiles in early MF are different from those in inflammatory skin diseases.
8.A control study of video -assisted thoracoscopic surgery (VATS)and conventional thoracotomy in treatment of thoracic esophagus cancer
Jian LI ; Xiaoming BAI ; Yun FENG ; Juntao HAO ; Lifeng MENG ; Wen ZHOU ; Jun MA
Chinese Journal of Primary Medicine and Pharmacy 2016;23(10):1463-1465,1466
Objective To investigate the effect of video -assisted thoracoscopic surgery (VATS)and conventional thoracotomy in treatment of thoracic esophagus cancer,to provide the reference for clinical.Methods 90 cases of thoracic esophageal cancer in our hospital from January 2012 to January 2015 were chosen as the research subjects.They were randomly divided into observation group(application of VATS treatment)and the control group (application of traditional open chest surgery).The quantity difference,chest drainage,hospitalization time,complica-tions,recovery conditions and other indicators of bleeding were compared in the two groups.Results The operation time of the observation group[(267.6 ±76.5)min]was shorter than that of the control group[(324.4 ±87.6)min]. The amount of intraoperative bleeding[(235.3 ±79.5)mL],drainage volume[(327.5 ±95.2)mL]of the observation group were less than the control group[(398.2 ±98.3)mL and (752.6 ±156.4)mL].Postoperative hospitalization time[(12.2 ±3.2)d]of the observation group was shorter than the control group[(15.8 ±4.4)d].The differences were statistically significant (t =3.276,8.644,15.575,4.439,all P <0.05).There were no significant differences between two groups in recurrence and metastasis rate,mortality rate and total survival rate (χ2 =0.123,0.212, 0.212,all P >0.05).The complication rate of the observation group was lower than that of the control group,the difference was statistically significant (χ2 =4.865,P <0.05).Conclusion In the treatment of thoracic esophageal carcinoma,VATS and conventional thoracotomy surgery has good effect,and VATS has small injury,less complication.
9.Numerical simulation of hemodynamics in a bioresorbable vascular scaffold
peng Ye ZHANG ; Min ZHOU ; hao Wen TANG
Chinese Journal of Tissue Engineering Research 2017;21(34):5532-5537
BACKGROUND: Stent implantation cannot only cause an adaptive change of blood vessels, but also result in intravascular hemodynamic changes, including vascular wall shear stress and disturbance flow.OBJECTIVE: To provide a theoretical basis for optimizing the stent design based on hemodynamics evaluation of the stented blood vessel by numerical simulation.METHODS: Hemodynamics of the stented vessels were simulated by three-dimensional modeling,vessel-stent coupling, mesh partioning, boundary conditions setting. Then the trends of wall shear stress on six different vascular stent models were assessed and compared.RESULTS AND CONCLUSION: The wall shear stress had the changing trend consistent with the inlet velocity. The wall shear stress was increased or decreased with the increase of decrease of inlet velocity, and reached or became close to the valley value when the inlet velocity was at valley value. This change rule was not affected by the structural change of the stent model. In the same stent model, the minimum wall shear stress at each point was less than 0.5 Pa, and these minimum values < 0.5 Pa lasted for different time in each cardiac cycle. In different stent models, the amount of points where the wall shear stress was less than 0.5 Pa in different cardiac cycles were in variety. To conclude, the wall shear stress at a point of the wall is positively correlated with the inlet velocity. During a cardiac cycle, at some time points, intimal hyperplasia is prone to occur in the region with the wall shear stress less than 0.5 Pa. Therefore, we should try to minimize the low wall shear stress region.
10.Comparative analysis between three dimentional reconstruction coronary angiography with CardiOp-B system and conventional quantitative coronary angiography
Hao, XU ; Guo-wei, ZHOU ; Qiu-yan, DAI ; Shao-wen, LIU
Journal of Shanghai Jiaotong University(Medical Science) 2009;29(6):646-648
Objective To investigate the accuracy of three-dimensional reconstruction coronary angiography with CardiOp-B system in the evaluation of coronary artery stenosis, and make comparison with conventional quantitative coronary angiography(QCA). Methods The imaging data of 33 patients (39 vessel segments) who underwent coronary angiography and received interventional therapy were collected. The vessel diameter, vessel area, diameter of reference vessel rate of stenosed area and lesion length detected by three-dimensional reconstruction coronary angiography and QCA were compared. Results There was no significant difference in the detected minimal vessel diameter, minimal vessel area, diameter of reference vessel, rate of stenosed area and lesion length between three-dimensional reconstruction coronary angiography and QCA in these 39 vessel segments (P > 0.05), while the lesion length detected by three-dimensional reconstruction coronary angiography was significantly longer than that detected by QCA(P < 0.05). Conclusion Three-dimentional reconstruction of coronary angiography with CardiOp-B system demonstrates higher accuracy in the quantitative analysis of coronary artery stenosis compared with conventional QCA.