Objective To evaluate the efficacy and safety of ievamlodipine besylate and felodipine for patients with mild and moderate essential hypertension. Methods One hundred and four eases with essential hypertension were divided randomly into two groups:levamlodipine besylate group and felodipine group. Treatment lasted for 4 weeks. Parameters of blood pressure were measured before and after treatment. Results There was no significant difference in responder rates between patients taking levamlodipin besylate(84.62%) and patients taking felodipine(80.77%)(P>0.05). The untoward reaction in patients taking levamlodipine besylate(7.69%) was lower than that in patients taking felodipine(17.31%)(P < 0.05). Conclusion Levamlodipine besylate has effective at lowering blood pressure and light untoward reaction.