Objective To explore the application of Trinity new model home nursing on continuous control of blood sugar in patients with type 2 diabetes mellitus. Methods Totally 98 patients with type 2 diabetes were selected from January 2016 to December 2017 in our hospital, who were divided into study group and control group by random number table, and there were 49 cases in each group. The control group was given conventional nursing until the hospital was discharged, and the routine follow-up was given after discharge. The study group was given conventional nursing until the hospital was discharged, and the new type of new home nursing mode was given after discharge. The levels of fasting blood glucose (FBG), postprandial 2h blood glucose (2h PBG) and glycated hemoglobin (HbAc1) were compared between the 2 groups at 1d before discharge, 1 months and 3 months after discharge, and the patients compliance were compared, then the quality of life of patients at discharge and 3 months after discharge were assessed by the diabetes specific quality of life scale (DSQL). Results The levels of FBG, 2h PBG and HbAc1respectively were(7.08 ± 0.58) mmol/L, (10.06 ± 0.72) mmol/L, (6.11 ± 0.40)％of the study group at 1d before discharge, of which the control group respectively were(7.07±0.61) mmol/L, (10.07±0.74) mmol/L, (6.10±0.42)％.The levels of FBG, 2h PBG and HbAc1respectively were(6.13±0.44) mmol/L, (9.51 ± 0.55) mmol/L, (5.51 ± 0.30)％of the study group at 1 months after discharge, of which the control group respectively were (6.58 ± 0.56) mmol/L, (9.75 ± 0.53) mmol/L, (5.82 ± 0.34)％ .The levels of FBG, 2h PBG and HbAc1 respectively were(5.69±0.42) mmol/L, (9.03±0.44) mmol/L, (5.22±0.23)％of the study group at 3 months after discharge, of which the control group respectively were (6.17±0.40) mmol/L, (9.46±0.48) mmol/L, (5.51±0.20)％. The levels of FBG, 2h PBG and HbAc1 had significant differences in the interaction between groups and time (F=2.892-5.749, P<0.05). The complete compliance rate of the study group(79.59％, 39/49) was significantly higher than that of the control group (61.22％, 30/49) (χ2=3.967, P=0.046), and then on-compliance rate of the study group (2.04％) was significantly lower than that of the control group (14.29％) (χ2=4.900, P=0.027).The scores of the physiological function, psychology or spirit, social relationship, treatment and DSQL total score of the study group at discharge respectively were (26.62 ± 4.35), (20.21 ± 3.19), (10.36 ± 2.32), (7.42 ± 0.54), (64.61 ± 9.27),of which the control group respectively were(26.49 ± 4.18), (20.17 ± 3.25), (10.45 ± 2.44,(7.35 ± 0.57), (64.46 ± 10.38).The scores of the physiological function, psychology or spirit, social relationship, treatment and DSQL total score of the study group at3 months after discharge respectively were (17.33±3.96), (11.97±2.84), (5.01±1.14), (4.25± 0.49), (38.07±7.12), of which the control group respectively were (21.72±3.51), (15.46±3.08), (7.18±1.85), (5.13 ± 0.48), (49.49 ± 8.74).The scores of the physiological function, psychology or spirit, social relationship, treatment and DSQL total score of the 2 groups at 3 months after discharge were significantly lower than those at discharge (t = 6.117-30.432, all P<0.01), and the scores of each dimension and total score of the study group were significantly lower than those of the control group at 3 months after discharge (t=5.087-8.981, 7.091, all P<0.01). Conclusion The Trinity new model home nursing can obviously improve the blood sugar indexes of patients with type 2 diabetes after discharge, improve the compliance and the quality of life, which has the value of popularization and application.