ObjectiveTo explore the effective measures to prevent and control the hospital infections.MethodsThe hospital infections'data of 27 129 inpatients were retrospectively studied and retrospectively analyzed.ResultsThe nosocomial infection rate was 3.40％. The major sites of the infection were lower respiratory tract (50.05％ ). The most common pathogens were mainly Gram-negative bacteria (41.91％ ). The infection mainly occurs in old peple(75.34％ ). The highest infection rate is in organ transplantation unit( 14.62％ ). The factors of high risk included antibiotics(53.47％ ), immunocompromise and invasive therapies. ConclusionTo improve the pathogen detective rate and the monitoring of antibiotic resistance ,to decrease the use of invasive therapies and to keep high risk areas under surveillance were the effective measures to control hospital infection and to reduce the incidence rate of hospital infection.