OBJECTIVE:To study the effects of nimesulide combined with oxaliplatin on microvessel density and immune func-tion of esophageal cancer model rats. METHODS:48 rats were selected to establish esophageal cancer model and then randomly di-vided into model group,oxaliplatin group,nimesulide group and combination group,with 12 rats in each group. 1 d after model-ing,model group was given 5% Glucose injection 1 mL via tail vein,3 times a week,and constant volume of Sodium carboxy-methylcellulose solution,once a week. Oxaliplatin group was given oxaliplatin 13.6 mg/kg via tail vein,3 times a week. Nimesu-lide group was given nimesulide 20 mg/kg intragastrically,once a week. Combination group was given oxaliplatin and nimesulide with same usage as above. The administration lasted for 8 weeks. The cancer growth,microvessel density of cancer tissue,peripher-al blood immune function index were observed in four groups. RESULTS:Compared with model group,cancer size,cancer weight,integral absorbance of cancer and positive vessel density were all decreased in treatment groups(P<0.05). The number of peripheral blood CD3+,CD4+T cells and CD4+/CD8+were all decreased in oxaliplatin group and combination group,while the num-ber of CD8+T cells was decreased(P<0.05). Compared with nimesulide group,cancer size,cancer weight,integral absorbance of cancer,positive vessel density,the number of peripheral blood CD3+,CD4+T cells and CD4+/CD8+ were all decreased in oxaliplat-in group and combination group,while tumor inhibition rate and the number of CD8+T cells were all increased(P<0.05);combi-nation group was more significant than oxaliplatin group (P<0.05). CONCLUSIONS:Oxaliplatin combined with nimesulide can effectively inhibit cancer growth of esophageal cancer,the mechanism of which may be associated with inhibiting angiogenesis of tumor tissue and strengthening immune function.

Objective To study the changes of soluble intercelluar adhesion molecule-1 (sICAM-1) in serum of neonates with hy-poxic-ischemic encephalopathy (HIE),and significance of changes of serum sICAM-1 in HIE pathogenesis. Methods There were 17 controls of neonates and their sICAM-1 concentrations in serum were detected with enzyme-linked immunosorbent assay (ELISA) at the critical stage and at the beginning of convalescent stage in 36 cases of HIE neonates and 17 normal neonates. The data were analyzed with analysis of variance, Newman-Keuls q test. Results The concentrations of sICAM-l[(216.64?85.32)?g/L] at the critical stage of 36 cases HIE neonates were significantly higher than those [(6. 16?4.05) ?g/L ] of control group (q = 17. 42 P

OBJECTIVE:To investigate clinical efficacy and safety of Kang'ai injection adjuvant chemotherapy for advanced lung cancer. METHODS:A total of 146 patients with advanced lung cancer during May 2013-Apr. 2014 were divided into observa-tion group and control group according to odd-even admission number,with 73 cases in each group. Control group was given GP (gemcitabine+cisplatin)chemotherapy. Observation group was additionally given Kang'ai injection 60 mL added into normal saline 250 mL,qd,ivgtt,for consecutive 14 d each chemotherapy cycle,on the basis of control group. Both groups were given tropise-tron 5 mg for preventing gastrointestinal reaction during chemotherapy. A treatment course lasted for 3 weeks,and both groups were treated for 3 courses. Clinical efficacies of 2 groups were compared;the levels of serum inflammatory factors (hs-CRP, TNF-α,IFN-γ,IL-10),immune function indexes(CD3+,CD4+,CD8+,CD4+/CD8+)and tumor markers(SCC-Ag,CEA,CA50, CA72-4) were compared before and after treatment. The occurrence of ADR were recorded in 2 groups. RESULTS:The response rate and disease control rate of observation group were 39.73％ and 84.93％,which were significantly higher than 23.29％ and 71.23％ of control group,with statistical significance(P<0.05). Before treatment,there was no statistical significance in the lev-els of serum inflammatory factors,immune function indexes or tumor markers between 2 groups (P>0.05). After treatment,the levels of hs-CRP,TNF-αand IFN-γin 2 groups were significantly lower than before treatment,while the level of IL-10 was signifi-cantly higher than before treatment;above indexes of observation group were significantly better than control group,with statistical significance(P<0.05). The levels of CD4+ and CD4+/CD8+ in control group were decreased significantly and lower than observa-tion group,with statistical significance(P<0.05). Serum levels of SCC-Ag,CEA,CA50 and CA72-4 in 2 groups were decreased significantly,and observation group was significantly lower than control group,with statistical significance(P<0.05). The inci-dence of thrombocytopenia,neutropenia,abnormal liver function,nausea and vomiting,anemia in observation group were signifi-cantly lower than control group,with statistical significance(P<0.05). CONCLUSIONS:Kang'ai injection adjuvant chemothera-py can effectively relieve inflammation symptoms of patients with advanced lung cancer,reduce toxic reactions,enhance immune function, and improve short-term therapeutic efficacy with good safety.