ObjectiveTo compare the safety and efficacy of combined thrombolysis and systemic anticoagulation therapy for the treatment of cerebral venous and sinus thrombosis (CVST).MethodsA retrospective review of consecutive inpatients with CVST was undertaken. Patients were divided into two groups,combined thrombolysis group (CTG) and systemic anticoagulation group (SAG).CTG underwent improved thrombolysis scheme which included mechanical thrombus maceration and unremitting microdosis urokinase injection into the venous sinus besides low molecular weight heparin anticoagulation.Neurological deficits before and after treatment were graded with the National Institute of Health Stroke Scale (NIHSS).Functional outcomes at discharge were graded on the modified Rankin Scale (mRS).ResultsThere were 30 cases in CTG ( male =9) and 86 cases in SAG ( male =23 ).There was no significant difference of neurological deficits before treatment between two groups(0-19 vs 0-17,Z =-0.474,P =0.636).After treatment,NIHSS and mRS at discharge were significantly decreased in CTG compared to SAG.There was no significant difference on the incidence of intracerebral hemorrhage.Conclusions Combined thrombolysis is better than systemic anticoagulation in improving neurological function.Combined thrombolysis does not increase incidence of ICH compared to systemic anticoagulation.

Objective: Toexplore work process-oriented theory nursing ward round, research work process-oriented theory nursing ward round on critical thinking capacity of nursing undergraduates. Methods: Totally 80 Elective nursing ward round courses of nursing undergraduates were divided into the experimental A group and the experimental b group with 40 cases in each group. The experimental A group select the beginning of 9 weeks on Until, the experimental B group select the after of 9 weeks on Until. The nursing undergraduates were assessed by CTDI-CV on first, ninth, eighteenth weeks to evaluate the effect of the two groups. Results: Main effect of group factor and time factor of CTDI-CV had statistical significance (P<0.05) . There were significant interaction in the scores of CTDI-CV. Simple effect analysis demonstrated the scores of CTDI-CV in the experimental A group were higher than those of the experimental b group after the intervention (P<0.05) . Two groups of on first, ninth, eighteenth weeks measured values compared the effect of amount of F_B<F_A, the experimental group A intervention effect was better than in the experimental group B intervention. Conclusions For nursing undergraduates guided based on the working process of the curriculum of nursing ward round the critical thinking ability had good practice guidance, and on the start time to choose university grade three semester two on 9 weeks before commencement of nursing undergraduates promotes higher critical thinking ability.