OBJECTIVE:To establish scientific and rational management of second kind psychotropic drugs.METHODS:The account book of second kind psychotropic drugs was set up according to specification of narcotic drugs and first kind psychotropic drugs.Daily radix management was carried out by exclusive person,account book and counter,as compared with traditional management.RESULTS & CONCLUSIONS:In this management method,checking time was decreased to 20 min from 50 min.The rate of consistency between account and drug was up to 98% from 95%.The method is superior to traditional one.

Mammal metallothionein(MT) folds into two separate domains that exhibit different structure and metal binding propertity independently, the study of the strategy of metal ions binding with MT would give better understanding of their exact biological functional mechanisms. In this study, a method using eletrospray ionization mass spectrometry (ESI-MS) phase liquid chromatography and identified by ESI-MS. Different amounts of Cd or Cu were then added in MT-2a samples and ESI-MS was employed to determine the mass difference of MT in different samples. The results Cd2+4S11; while Cd is attached in separate binding sites for the formation of Cd2+3S9 cluster, which intermediately formed with five and six Cd ions were detected. For the Cuprous ions, it prefers to cooperatively bind in β-domain with the form of Cu4-MTβ. The binding form in β-domain would convert from Cu4 into more Cu binding form with the addition of Cu. When high concentration of Cu was added in samples, the result suggested that

AIM: To explore the antitumor mechanisms of bifidobacteria adolescence in vivo. METHODS: The activity of NF-?B and its inhibiting protein I ?B? of large bowel carcinoma tissues was detected by using laser scanning confocal microscope and immunohistochemistry. RESULTS: The positive cell density of NF-?B of large bowel carcinoma transplantation tumors in bifidobacterium injection group was markedly lower than that in tumor control group( P